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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4id71G0Activated CDC42 kinase 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4id71G0Activated CDC42 kinase 1/1.000
3vs1VSATyrosine-protein kinase HCK2.7.10.20.528
1bygSTUTyrosine-protein kinase CSK/0.525
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.520
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.519
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.516
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.515
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.515
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.513
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.508
2c6eHPMAurora kinase A2.7.11.10.505
3vs3VSETyrosine-protein kinase HCK2.7.10.20.505
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.500
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.498
3w33W19Epidermal growth factor receptor2.7.10.10.497
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.495
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.492
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.492
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.492
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.491
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.491
3w32W32Epidermal growth factor receptor2.7.10.10.488
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.487
2hk51BMTyrosine-protein kinase HCK2.7.10.20.486
3poz03PEpidermal growth factor receptor2.7.10.10.485
3uvqFS8Mitogen-activated protein kinase 14/0.485
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.483
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.482
3vjoANPEpidermal growth factor receptor2.7.10.10.481
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.480
5e8wSTUTGF-beta receptor type-12.7.11.300.478
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.477
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.475
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.475
4nka2K7Fibroblast growth factor receptor 1/0.475
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.474
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.474
4aotGW8Serine/threonine-protein kinase 102.7.11.10.473
4gk3L87Ephrin type-A receptor 32.7.10.10.472
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.471
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.470
2vwu7X1Ephrin type-B receptor 42.7.10.10.469
2xp2VGHALK tyrosine kinase receptor2.7.10.10.469
3w18N13Aurora kinase A2.7.11.10.469
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.469
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.469
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.469
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.468
2qo9ANPEphrin type-A receptor 32.7.10.10.466
2xvdAS6Ephrin type-B receptor 42.7.10.10.466
3erkSB4Mitogen-activated protein kinase 12.7.11.240.466
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
2itnANPEpidermal growth factor receptor2.7.10.10.465
2qoqANPEphrin type-A receptor 32.7.10.10.465
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.465
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.465
1u54ACPActivated CDC42 kinase 1/0.464
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.464
2itvANPEpidermal growth factor receptor2.7.10.10.463
4i22IREEpidermal growth factor receptor2.7.10.10.463
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.461
3ttjJBIMitogen-activated protein kinase 102.7.11.240.461
4riyADPEpidermal growth factor receptor2.7.10.10.461
1xkkFMMEpidermal growth factor receptor2.7.10.10.460
2zybKSLTyrosine-protein kinase Lck2.7.10.20.460
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.460
2yxuATPPyridoxal kinase2.7.1.350.459
4gk4L90Ephrin type-A receptor 32.7.10.10.458
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.458
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.458
3fhyATPPyridoxal kinase2.7.1.350.457
2b9wFADPutative aminooxidase/0.456
2henADPEphrin type-B receptor 22.7.10.10.456
4c4h7RODual specificity protein kinase TTK2.7.12.10.456
4fob0USALK tyrosine kinase receptor2.7.10.10.456
4jboWPHAurora kinase A2.7.11.10.456
5aaaVGHALK tyrosine kinase receptor2.7.10.10.456
1m17AQ4Epidermal growth factor receptor2.7.10.10.455
2y6o1N1Ephrin type-A receptor 42.7.10.10.455
4hjoAQ4Epidermal growth factor receptor2.7.10.10.455
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
4wkqIREEpidermal growth factor receptor2.7.10.10.454
2j7t274Serine/threonine-protein kinase 102.7.11.10.453
2vrx447Aurora kinase B-A2.7.11.10.453
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.453
4en4ATPPyridoxal kinase2.7.1.350.453
4g2fC07Ephrin type-A receptor 32.7.10.10.453
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.452
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.452
3mg3ECHOrange carotenoid-binding protein/0.452
3w2o03PEpidermal growth factor receptor2.7.10.10.452
4c4g7RODual specificity protein kinase TTK2.7.12.10.452
4c58824Cyclin-G-associated kinase2.7.11.10.452
4q73FADBifunctional protein PutA/0.452
5l8lADPAurora kinase A2.7.11.10.452
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.451
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.450
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.450
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.450
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.450
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.449
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.448
1rw8580TGF-beta receptor type-12.7.11.300.448
1u4dDBQActivated CDC42 kinase 1/0.448
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.448
3icsCOACoenzyme A disulfide reductase/0.448
4i231C9Epidermal growth factor receptor2.7.10.10.448
2vwz7X6Ephrin type-B receptor 42.7.10.10.447
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.447
3ac2KSETyrosine-protein kinase Lck2.7.10.20.447
3ttiKBIMitogen-activated protein kinase 102.7.11.240.447
3vthAPCCarbamoyltransferase/0.447
4c4f7CEDual specificity protein kinase TTK2.7.12.10.447
4wlvNADMalate dehydrogenase, mitochondrial1.1.1.370.447
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2vww7X2Ephrin type-B receptor 42.7.10.10.446
2x9fX9FEphrin type-B receptor 42.7.10.10.446
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.446
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.446
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.446
5awmANPStress-activated protein kinase JNK2.7.11.240.446
2vwy7X5Ephrin type-B receptor 42.7.10.10.445
3gxlQIGTGF-beta receptor type-12.7.11.300.445
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.445
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.444
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.444
4c4iX20Dual specificity protein kinase TTK2.7.12.10.444
4gk2L66Ephrin type-A receptor 32.7.10.10.444
2itqITQEpidermal growth factor receptor2.7.10.10.443
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.442
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.442
3tqhNDPQuinone oxidoreductase/0.442
4b8mVX6Aurora kinase B-A2.7.11.10.442
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.442
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.442
2of4979Tyrosine-protein kinase Lck2.7.10.20.441
2vx17X8Ephrin type-B receptor 42.7.10.10.441
2znnS44Peroxisome proliferator-activated receptor alpha/0.441
4bb432WEphrin type-B receptor 42.7.10.10.441
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.441
4gyiADPUncharacterized protein/0.441
4jbqVX6Aurora kinase A2.7.11.10.441
4nks2M2Fibroblast growth factor receptor 1/0.441
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.441
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.441
2xyuQ9GEphrin type-A receptor 42.7.10.10.440
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.440