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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.649
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.640
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.547
4xw5ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.542
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.538
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.537
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.523
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.507
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.507
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.505
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.503
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.501
4qnyANPMitogen activated protein kinase, putative/0.499
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.486
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.485
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.480
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
4ysjADPCalmodulin-like domain protein kinase/0.477
2ojj82AMitogen-activated protein kinase 12.7.11.240.475
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
4eooATPCyclin-dependent kinase 22.7.11.220.471
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.470
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.469
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.469
3zo4QWIcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
4fv6E57Mitogen-activated protein kinase 12.7.11.240.468
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.466
2jdtI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.465
1qmzATPCyclin-dependent kinase 22.7.11.220.464
1xhaR68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
5dosATPAurora kinase A2.7.11.10.460
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
2yaaATPDeath-associated protein kinase 2/0.458
4l9i8PRRhodopsin kinase/0.456
3c4wATPRhodopsin kinase/0.455
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.453
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.450
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.450
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.449
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.447
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.447
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.446
2etrY27Rho-associated protein kinase 12.7.11.10.445
4j95ACPFibroblast growth factor receptor 2/0.445
4j99ACPFibroblast growth factor receptor 2/0.443
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3c4xATPRhodopsin kinase/0.441