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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4iafADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4iafADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
3fjqATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.648
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.623
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.611
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.608
4hptANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.589
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.589
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.572
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.561
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.551
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.550
3idbANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.549
4dg3ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.549
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.532
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.531
4dh7ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.531
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.530
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.530
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
4iaiADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.519
4wb6ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.512
4xw5ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
5iqiGNPBifunctional AAC/APH2.3.10.505
4iadADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.503
5iqeGNPBifunctional AAC/APH2.3.10.503
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.500
3fhiANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.490
4xw6ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
4orkGDPBifunctional AAC/APH2.3.10.489
5iqgGDPBifunctional AAC/APH2.3.10.489
1cdkANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.488
3c4zADPRhodopsin kinase/0.484
5iqdGNPBifunctional AAC/APH2.3.10.481
4ysjADPCalmodulin-like domain protein kinase/0.477
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
5bylGCPBifunctional AAC/APH2.3.10.477
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
2qcsANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
4s33ANPMitogen-activated protein kinase 12.7.11.240.473
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
4dh3ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
1okkGCPSignal recognition particle protein/0.469
1okkGCPSignal recognition particle receptor FtsY/0.469
5iqbGNPBifunctional AAC/APH2.3.10.469
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.468
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.468
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.460
5iqhGNPBifunctional AAC/APH2.3.10.459
1jkkANPDeath-associated protein kinase 12.7.11.10.458
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.458
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.458
5dnrATPAurora kinase A2.7.11.10.458
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3c4wATPRhodopsin kinase/0.455
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.455
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.454
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.452
2uw4L15cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.451
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3a8wATPProtein kinase C iota type2.7.11.130.448
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4fv6E57Mitogen-activated protein kinase 12.7.11.240.448
4ib3ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
5iqaGNPBifunctional AAC/APH2.3.10.447
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.446
4ikeADPAdenylate kinase/0.446
1o6kANPRAC-beta serine/threonine-protein kinase2.7.11.10.445
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.445
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.445
5iqfGDPBifunctional AAC/APH2.3.10.445
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.444
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.444
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
2qoqANPEphrin type-A receptor 32.7.10.10.442
2wp9CBESuccinate dehydrogenase iron-sulfur subunit1.3.5.10.442
2wp9CBESuccinate dehydrogenase cytochrome b556 subunit/0.442
1rejB1LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2ad5ADPCTP synthase/0.440
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.440