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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4i9bNADPutative betaine aldehyde dehyrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4i9bNADPutative betaine aldehyde dehyrogenase/1.000
3iwjNADAminoaldehyde dehydrogenase/0.629
3iwkNADAminoaldehyde dehydrogenase/0.590
2bjaNAD1-pyrroline-5-carboxylate dehydrogenase/0.546
5eyuNADBetaine-aldehyde dehydrogenase/0.542
4fr8ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.539
1o02NADAldehyde dehydrogenase, mitochondrial1.2.1.30.537
1wnbNAIGamma-aminobutyraldehyde dehydrogenase1.2.1.190.537
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.535
2ehqNAP1-pyrroline-5-carboxylate dehydrogenase/0.531
2j40NAD1-pyrroline-5-carboxylate dehydrogenase/0.529
3ju8NADN-succinylglutamate 5-semialdehyde dehydrogenase1.2.1.710.529
3n82NADAldehyde dehydrogenase, mitochondrial1.2.1.30.527
4pt0NADAldehyde dehydrogenase/0.524
2eitNAD1-pyrroline-5-carboxylate dehydrogenase/0.523
4pt3NDPAldehyde dehydrogenase/0.523
4pxlNADAldehyde dehydrogenase3/0.522
1nzzNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.521
1nzxNADAldehyde dehydrogenase, mitochondrial1.2.1.30.518
1ad3NADAldehyde dehydrogenase, dimeric NADP-preferring/0.514
2eiiNAD1-pyrroline-5-carboxylate dehydrogenase/0.513
2onpNADAldehyde dehydrogenase, mitochondrial1.2.1.30.510
1bxsNADRetinal dehydrogenase 11.2.1.360.508
4x4lNAIRetinal dehydrogenase 11.2.1.360.507
4fqfNADAldehyde dehydrogenase, mitochondrial1.2.1.30.502
4fr8NADAldehyde dehydrogenase, mitochondrial1.2.1.30.502
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.500
4x2qNADRetinal dehydrogenase 21.2.1.360.498
4pz2NADAldehyde dehydrogenase 2-6/0.497
1o00NADAldehyde dehydrogenase, mitochondrial1.2.1.30.494
4wb9NAIRetinal dehydrogenase 11.2.1.360.493
1bpwNADBetaine aldehyde dehydrogenase1.2.1.80.490
4i3vNADAldehyde dehydrogenase (NAD+)/0.490
1cw3NADAldehyde dehydrogenase, mitochondrial1.2.1.30.489
2wmeNAPNAD/NADP-dependent betaine aldehyde dehydrogenase/0.488
2onmNADAldehyde dehydrogenase, mitochondrial1.2.1.30.486
2onmADPAldehyde dehydrogenase, mitochondrial1.2.1.30.486
4oe2NAD2-aminomuconate 6-semialdehyde dehydrogenase/0.486
4go2TAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.485
4f3xNADPutative aldehyde dehydrogenase/0.484
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.482
2ikuLIYRenin3.4.23.150.482
2g1s4IGRenin3.4.23.150.473
4zz7NADMethylmalonate-semialdehyde dehydrogenase/0.473
4i1wNAD2-aminomuconate 6-semialdehyde dehydrogenase/0.471
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.469
3lqfNADGalactitol dehydrogenase/0.462
3h3sH15Collagen type IV alpha-3-binding protein/0.461
2iko7IGRenin3.4.23.150.460
3h3t16HCollagen type IV alpha-3-binding protein/0.460
3own3OWRenin3.4.23.150.457
2bf4FMNNADPH--cytochrome P450 reductase/0.455
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.455
4bfzZVZPantothenate kinase2.7.1.330.455
1nzwNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.454
4m4922YL-lactate dehydrogenase A chain1.1.1.270.453
4dc0NDPPutative ketoacyl reductase1.3.10.452
4h73NDPAldehyde dehydrogenase/0.452
4oe4NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.452
1xkdNAPIsocitrate dehydrogenase [NADP]/0.450
3v9lNADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.450
1o04NADAldehyde dehydrogenase, mitochondrial1.2.1.30.449
2g1n1IGRenin3.4.23.150.449
2g226IGRenin3.4.23.150.449
4bftZVTPantothenate kinase2.7.1.330.449
1rfvADPPyridoxal kinase2.7.1.350.448
2g247IGRenin3.4.23.150.448
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
3vucHHERenin3.4.23.150.447
1f8wFADNADH peroxidase1.11.1.10.446
2ejvNADL-threonine 3-dehydrogenase/0.446
3oqkS52Renin3.4.23.150.445
4bfvZVVPantothenate kinase2.7.1.330.445
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.444
3rk1ATPN-type ATP pyrophosphatase superfamily/0.444
4a6rTA8Probable aminotransferase/0.444
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.444
3gwfNAPCyclohexanone monooxygenase/0.443
3oqfS51Renin3.4.23.150.443
4ef8FMNDihydroorotate dehydrogenase (fumarate)/0.443
4ke11R6Beta-secretase 13.4.23.460.442
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.441
1v35NAIEnoyl-ACP reductase/0.441
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2he5NDPAldo-keto reductase family 1 member C211.1.10.441
2nn7M29Carbonic anhydrase 14.2.1.10.441
2v58LZJBiotin carboxylase6.3.4.140.441
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.441
4y3zF41Endothiapepsin3.4.23.220.441
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.441
2zsaADPPantothenate kinase2.7.1.330.440
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.440
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.440