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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4i8pNADAminoaldehyde dehydrogenase 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4i8pNADAminoaldehyde dehydrogenase 1/1.000
1a4zNADAldehyde dehydrogenase, mitochondrial1.2.1.30.621
4v37NADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.554
3rhrNDPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.499
3hazNADBifunctional protein PutA/0.495
1uxvNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.487
3rhqNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.486
3rhlNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.484
3rhjNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.473
1cw3NADAldehyde dehydrogenase, mitochondrial1.2.1.30.467
4gnzNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.459
1uxrNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.458
1ez0NAPNADP-dependent fatty aldehyde dehydrogenase1.2.1.40.449
1ky8NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.444