sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4i5x | FLF | Aldo-keto reductase family 1 member B10 | 1.1.1 | 1.000 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.521 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.503 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.497 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.492 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.491 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.490 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.489 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.487 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.485 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.483 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.482 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.481 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.480 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.480 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.480 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.480 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.479 | |
| 2b8j | ADN | Class B acid phosphatase | 3.1.3.2 | 0.478 | |
| 1aqu | EST | Estrogen sulfotransferase, testis isoform | 2.8.2.4 | 0.477 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.476 | |
| 4phl | PIL | Phosphodiesterase | / | 0.476 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.475 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.475 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.474 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.474 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.474 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.472 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.472 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.472 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.471 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.471 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.471 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.470 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.470 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.470 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.470 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.469 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.469 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.469 | |
| 4m48 | 21B | Sodium-dependent dopamine transporter | / | 0.469 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.468 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.468 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.467 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.466 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.466 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.466 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.466 | |
| 1lke | DOG | Bilin-binding protein | / | 0.465 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.465 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.465 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.465 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.465 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.464 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.464 | |
| 5d5a | CAU | Beta-2 adrenergic receptor | / | 0.464 | |
| 1mab | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.463 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 1s36 | CEI | Obelin | / | 0.463 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.463 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.463 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.462 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.461 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.460 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1gaq | FAD | Ferredoxin | / | 0.459 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.459 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.459 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3c1o | NAP | Eugenol synthase | / | 0.458 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.458 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.457 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.457 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.457 | |
| 3ce0 | P34 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.457 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.457 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 4i6f | 1C7 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.457 | |
| 4jvm | XDI | Estrogen sulfotransferase | 2.8.2.4 | 0.457 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.456 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.456 | |
| 3d4s | TIM | Beta-2 adrenergic receptor | / | 0.456 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.455 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 3n39 | FMN | Protein NrdI | / | 0.455 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.455 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.455 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.455 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.454 | |
| 1z5u | CMP | Class B acid phosphatase | / | 0.454 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.454 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 3c49 | KU8 | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.454 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.453 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.453 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.453 | |
| 2hzq | STR | Apolipoprotein D | / | 0.453 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.453 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.453 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.453 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.453 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.452 | |
| 1ni1 | 2C5 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.452 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.452 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.452 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.452 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.451 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.451 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.451 | |
| 1ypg | UIR | Prothrombin | 3.4.21.5 | 0.451 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.451 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.451 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.451 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3vo2 | FAD | Ferredoxin--NADP reductase | / | 0.451 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.451 | |
| 1h42 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.450 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.450 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.450 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.450 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.450 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.450 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.450 | |
| 4kxj | P34 | Nucleoprotein | / | 0.450 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.449 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.449 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2pd9 | FID | Aldose reductase | 1.1.1.21 | 0.449 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.449 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4fk3 | 325 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.449 | |
| 4gv2 | 5ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.449 | |
| 4hcy | 0YN | Transketolase | / | 0.449 | |
| 4i9z | 5BA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.449 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.448 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.448 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.448 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.448 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.448 | |
| 2ycw | CAU | Beta-1 adrenergic receptor | / | 0.448 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3pn1 | IVH | DNA ligase | / | 0.448 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 3up3 | XCA | aceDAF-12 | / | 0.448 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.448 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.448 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.448 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.447 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.447 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.447 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.447 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.447 | |
| 2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.447 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.447 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.447 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.447 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.447 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 4j7g | TRH | PCZA361.3 | / | 0.447 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.447 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.446 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1que | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.446 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.446 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.446 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.446 | |
| 4kn0 | MTX | Folate receptor beta | / | 0.446 | |
| 4l32 | 1VF | Tankyrase-2 | 2.4.2.30 | 0.446 | |
| 5cto | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.446 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.445 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.445 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.445 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.445 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.445 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.445 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.445 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.445 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.445 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.445 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.444 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.444 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.444 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.444 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.444 | |
| 2ow9 | SP6 | Collagenase 3 | 3.4.24 | 0.444 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.444 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.444 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.444 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4kd7 | 9DR | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 4mmd | 29E | Na(+):neurotransmitter symporter (Snf family) | / | 0.444 | |
| 4n9q | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.444 | |
| 4nt3 | ZAW | Lactoperoxidase | 1.11.1.7 | 0.444 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.443 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.443 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.443 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3r8g | IZP | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3zks | WZV | Beta-secretase 2 | 3.4.23.45 | 0.443 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.443 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4hhz | 15S | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.443 | |
| 4jq2 | SUZ | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.443 | |
| 4rel | KMP | Glycosyltransferase | / | 0.443 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1bh5 | GTX | Lactoylglutathione lyase | 4.4.1.5 | 0.442 | |
| 1fml | RTL | Retinol dehydratase | / | 0.442 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.442 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.442 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.442 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.442 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 4htx | 19F | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.442 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.441 | |
| 1qv0 | CZH | Obelin | / | 0.441 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2fap | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 2fap | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.441 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.441 | |
| 2rc6 | FAD | Ferredoxin--NADP reductase | / | 0.441 | |
| 2xkd | T3M | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.441 | |
| 2xnp | WCX | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.441 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.441 | |
| 3eku | CY9 | Actin-5C | / | 0.441 | |
| 3ufl | 508 | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.441 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4kbn | 25U | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.441 | |
| 2ycz | I32 | Beta-1 adrenergic receptor | / | 0.441 | |
| 1gjr | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.440 | |
| 1q6s | 214 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.440 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 1rxj | BNI | Streptavidin | / | 0.440 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.440 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2znk | 31U | Prothrombin | 3.4.21.5 | 0.440 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.440 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.440 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4buf | F36 | Tankyrase-2 | 2.4.2.30 | 0.440 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4jqa | ID8 | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.440 |