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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/1.000
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.590
4dc1NDPPutative ketoacyl reductase1.3.10.539
1w4zNAPPutative ketoacyl reductase1.3.10.537
4hwkNAPSepiapterin reductase1.1.1.1530.534
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.532
3sjuNDPKeto reductase/0.529
1xkqNDPUncharacterized protein/0.525
3qrwNDPPutative ketoacyl reductase1.3.10.525
1x7hNDPPutative ketoacyl reductase1.3.10.520
3p19NDPPutative blue fluorescent protein/0.517
1ipeNDPTropinone reductase 21.1.1.2360.516
4qecNAPElxO/0.516
1ae1NAPTropinone reductase 1/0.513
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.513
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.512
4j7uNAPSepiapterin reductase1.1.1.1530.511
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.508
1snyNAPLD36273p/0.499
1x7gNAPPutative ketoacyl reductase1.3.10.497
3toxNAPPutative oxidoreductase/0.497
5idwNAPShort-chain dehydrogenase/reductase SDR/0.497
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.495
1n5dNDPCarbonyl reductase [NADPH] 1/0.494
1pr9NAPL-xylulose reductase1.1.1.100.493
4j7xNAPSepiapterin reductase1.1.1.1530.491
1wntNAPL-xylulose reductase1.1.1.100.489
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.489
3tn7NJPShort-chain alcohol dehydrogenase/0.489
3l77NJPShort-chain alcohol dehydrogenase/0.488
3gy0NAPNAD(P)-dependent oxidoreductase/0.486
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.486
4qedNAPElxO/0.483
1xg5NAPDehydrogenase/reductase SDR family member 11/0.482
2bd0NAPSepiapterin reductase/0.482
3d3wNAPL-xylulose reductase1.1.1.100.482
1oaaNAPSepiapterin reductase1.1.1.1530.480
3ai3NDPNADPH-sorbose reductase/0.477
4bmvNAPShort-chain dehydrogenase/0.477
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.477
2jahNDPClavaldehyde dehydrogenase/0.476
2yutNAPPutative short-chain oxidoreductase/0.476
2dteNAIGlucose 1-dehydrogenase related protein/0.475
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.473
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.471
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.470
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.470
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.470
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.468
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.468
3lqfNADGalactitol dehydrogenase/0.467
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.467
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.464
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.462
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.462
3ai2NDPNADPH-sorbose reductase/0.462
5jlaNADPutative short-chain dehydrogenase/reductase/0.462
4gh5NADShort-chain dehydrogenase/reductase SDR/0.461
2wdzNADGalactitol dehydrogenase/0.460
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.459
3f1kNAPUncharacterized oxidoreductase YciK10.459
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.459
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.458
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.454
1gcoNADGlucose 1-dehydrogenase1.1.1.470.452
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.452
3ak4NADNADH-dependent quinuclidinone reductase/0.452
3uceNDPDehydrogenase/0.451
3w8dNAD3-hydroxybutyrate dehydrogenase/0.451
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.450
2p5uNADUDP-glucose 4-epimerase/0.449
4jbiNDPAlcohol dehydrogenase (Zinc)/0.449
2wsbNADGalactitol dehydrogenase/0.448
1g6kNADGlucose 1-dehydrogenase1.1.1.470.447
1rwbNADGlucose 1-dehydrogenase1.1.1.470.447
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.447
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.447
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.447
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.445
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.445
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.443
4nbwNADShort-chain dehydrogenase/reductase SDR/0.443
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.442
1geeNADGlucose 1-dehydrogenase1.1.1.470.441
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.441
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.441
3w8eNAD3-hydroxybutyrate dehydrogenase/0.441
4esoNAPPutative oxidoreductase/0.441
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.440