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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4i5cC5ITyrosine-protein kinase JAK1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4i5cC5ITyrosine-protein kinase JAK1/1.000
4e6d0NUTyrosine-protein kinase JAK2/0.656
4e4n0NLTyrosine-protein kinase JAK1/0.587
4ivb1J5Tyrosine-protein kinase JAK1/0.571
4fv6E57Mitogen-activated protein kinase 12.7.11.240.570
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.568
4aqc88ATyrosine-protein kinase JAK2/0.564
4hge15VTyrosine-protein kinase JAK2/0.563
4ehzJAKTyrosine-protein kinase JAK1/0.557
3lpbNVBTyrosine-protein kinase JAK2/0.551
4ji91M3Tyrosine-protein kinase JAK2/0.532
4e5w0NTTyrosine-protein kinase JAK1/0.524
3s1h56ZCyclin-dependent kinase 22.7.11.220.517
4e6q0NVTyrosine-protein kinase JAK2/0.514
2vv9IM9Cyclin-dependent kinase 22.7.11.220.513
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.513
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.513
4f081RSTyrosine-protein kinase JAK2/0.511
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.509
2j0m4STFocal adhesion kinase 12.7.10.20.508
4hvi19STyrosine-protein kinase JAK32.7.10.20.507
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.503
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.503
3rak03ZCyclin-dependent kinase 22.7.11.220.502
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.499
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.497
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.494
4qnyANPMitogen activated protein kinase, putative/0.491
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.490
2pvnP63Casein kinase II subunit alpha2.7.11.10.488
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
2vu3LZECyclin-dependent kinase 22.7.11.220.487
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.485
4fk60UJTyrosine-protein kinase JAK1/0.483
4h3qANPMitogen-activated protein kinase 12.7.11.240.483
3iok1P6Tyrosine-protein kinase JAK2/0.482
4ivc1J6Tyrosine-protein kinase JAK1/0.482
3i60E86Mitogen-activated protein kinase 12.7.11.240.481
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
4bbfO19Tyrosine-protein kinase JAK2/0.479
1ykr628Cyclin-dependent kinase 22.7.11.220.477
3be9P04Casein kinase II subunit alpha2.7.11.10.477
4e4l0NHTyrosine-protein kinase JAK1/0.477
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.476
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.476
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.475
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.474
3rvg17PTyrosine-protein kinase JAK2/0.474
4fmqANPMitogen-activated protein kinase 12.7.11.240.474
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.473
1g5sI17Cyclin-dependent kinase 22.7.11.220.472
3eyhIZATyrosine-protein kinase JAK1/0.472
4ei40Q2Tyrosine-protein kinase JAK1/0.472
5e8ySTUTGF-beta receptor type-22.7.11.300.472
1pxpCK8Cyclin-dependent kinase 22.7.11.220.471
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.471
4anmWULCasein kinase II subunit alpha2.7.11.10.471
4nifANPMitogen-activated protein kinase 12.7.11.240.471
4ivd15TTyrosine-protein kinase JAK1/0.470
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.470
1y91CT9Cyclin-dependent kinase 22.7.11.220.469
2c6iDT1Cyclin-dependent kinase 22.7.11.220.469
2w05FRTCyclin-dependent kinase 22.7.11.220.469
4btjATPTau-tubulin kinase 12.7.11.10.469
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.468
3lltANPProtein serine/threonine kinase-1/0.468
1yvj4STTyrosine-protein kinase JAK32.7.10.20.467
2pvmP29Casein kinase II subunit alpha2.7.11.10.467
4ii5ADPCyclin-dependent kinase 22.7.11.220.466
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.465
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
3eb0DRKUncharacterized protein/0.465
4bgh3I6Cyclin-dependent kinase 22.7.11.220.465
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.464
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.464
4dt9GMPAPH(2'')-Id/0.464
4erwSTUCyclin-dependent kinase 22.7.11.220.464
1p2a5BNCyclin-dependent kinase 22.7.11.220.463
1qmzATPCyclin-dependent kinase 22.7.11.220.463
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.463
1jklANPDeath-associated protein kinase 12.7.11.10.462
1pxoCK7Cyclin-dependent kinase 22.7.11.220.462
4fkv61KCyclin-dependent kinase 22.7.11.220.459
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.459
4wsqKSAAP2-associated protein kinase 12.7.11.10.459
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.458
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.458
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
3r8lZ30Cyclin-dependent kinase 22.7.11.220.457
4gmy0X5Tyrosine-protein kinase JAK2/0.457
5cvfATPCasein kinase II subunit alpha2.7.11.10.457
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.456
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.456
3a62STURibosomal protein S6 kinase beta-12.7.11.10.456
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.456
3ncz3NCRho-associated protein kinase 12.7.11.10.456
4k771Q4Tyrosine-protein kinase JAK1/0.456
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.456
2uzbC75Cyclin-dependent kinase 22.7.11.220.455
3zh8C58Protein kinase C iota type2.7.11.130.455
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.454
1m2pHNACasein kinase II subunit alpha2.7.11.10.454
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.454
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.454
3rmf20ZCyclin-dependent kinase 22.7.11.220.454
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.453
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.453
2ijmADPFocal adhesion kinase 12.7.10.20.453
2pvhP19Casein kinase II subunit alpha2.7.11.10.453
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3rkb12ZCyclin-dependent kinase 22.7.11.220.453
3sheI85MAP kinase-activated protein kinase 32.7.11.10.453
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.453
4eooATPCyclin-dependent kinase 22.7.11.220.453
1dayGNPCasein kinase II subunit alpha2.7.11.10.452
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.452
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.452
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.452
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3nynSGVG protein-coupled receptor kinase 62.7.11.160.452
4btjADPTau-tubulin kinase 12.7.11.10.452
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.451
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2vttLZDCyclin-dependent kinase 22.7.11.220.451
2w17I19Cyclin-dependent kinase 22.7.11.220.451
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.451
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.451
4j95ACPFibroblast growth factor receptor 2/0.451
2cciATPCyclin-dependent kinase 22.7.11.220.450
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.450
4aguD15Cyclin-dependent kinase-like 1/0.450
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.450
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.450
4o0wADNAurora kinase A2.7.11.10.450
5dnrATPAurora kinase A2.7.11.10.450
1d4iBEGGag-Pol polyprotein3.4.23.160.449
2fvdLIACyclin-dependent kinase 22.7.11.220.449
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.449
4s33ANPMitogen-activated protein kinase 12.7.11.240.449
2uzdC85Cyclin-dependent kinase 22.7.11.220.448
3uli1N3Cyclin-dependent kinase 22.7.11.220.448
1w5yBE6Gag-Pol polyprotein3.4.23.160.447
2bqvA1AProtease/0.447
3kddJZQGag-Pol polyprotein3.4.23.160.447
4y93746Tyrosine-protein kinase/0.447
1pyePM1Cyclin-dependent kinase 22.7.11.220.446
2xa4AZ5Tyrosine-protein kinase JAK2/0.446
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.446
3nieANPMitogen-activated protein kinase/0.446
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.446
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.446
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.446
5ap7SVEDual specificity protein kinase TTK2.7.12.10.446
1idb0DOGag-Pol polyprotein/0.445
2c6lDT4Cyclin-dependent kinase 22.7.11.220.445
3gubGUBDeath-associated protein kinase 12.7.11.10.445
3kvxFMYMitogen-activated protein kinase 102.7.11.240.445
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.445
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.445
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.445
4jia1K3Tyrosine-protein kinase JAK2/0.445
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.444
2w4jADPDeath-associated protein kinase 12.7.11.10.444
3gu7ADPDeath-associated protein kinase 12.7.11.10.444
3vqhIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
4fv9E71Mitogen-activated protein kinase 12.7.11.240.444
5e92ANPTGF-beta receptor type-22.7.11.300.444
1oitHDTCyclin-dependent kinase 22.7.11.220.443
1xjdSTUProtein kinase C theta type2.7.11.130.443
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2vtsLZCCyclin-dependent kinase 22.7.11.220.443
4ysjADPCalmodulin-like domain protein kinase/0.443
1k6cMK1Gag-Pol polyprotein3.4.23.160.442
2j0lANPFocal adhesion kinase 12.7.10.20.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.442
3at4CCKCasein kinase II subunit alpha2.7.11.10.442
3nu3478Gag-Pol polyprotein3.4.23.160.442
3zewSTUEphrin type-B receptor 42.7.10.10.442
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.442
4j98ACPFibroblast growth factor receptor 2/0.442
1msmJE2Gag-Pol polyprotein3.4.23.160.441
1pkdUCNCyclin-dependent kinase 22.7.11.220.441
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.441
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.441
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.441
4j99ACPFibroblast growth factor receptor 2/0.441
4s34ANPMitogen-activated protein kinase 12.7.11.240.441
5cnoANPEpidermal growth factor receptor2.7.10.10.441
1pxmCK5Cyclin-dependent kinase 22.7.11.220.440
2b7aIZATyrosine-protein kinase JAK2/0.440
2uzoC62Cyclin-dependent kinase 22.7.11.220.440
3w2sW2REpidermal growth factor receptor2.7.10.10.440
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.440
5av2KMPDeath-associated protein kinase 12.7.11.10.440
5cnnANPEpidermal growth factor receptor2.7.10.10.440