sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4i3p | 1CW | 3-hydroxyanthranilate 3,4-dioxygenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4i3p | 1CW | 3-hydroxyanthranilate 3,4-dioxygenase | / | 1.000 | |
| 2x60 | GTP | Mannose-1-phosphate guanylyltransferase | / | 0.501 | |
| 4ysw | NAI | Xanthine dehydrogenase/oxidase | / | 0.475 | |
| 3gmb | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.472 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.457 | |
| 5cns | CDP | Ribonucleoside-diphosphate reductase 1 subunit alpha | 1.17.4.1 | 0.457 | |
| 2yx6 | ADP | Uncharacterized protein | / | 0.456 | |
| 4i9a | NCN | Nicotinate-nucleotide pyrophosphorylase [carboxylating] | / | 0.455 | |
| 4jy2 | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.453 | |
| 5cdg | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.453 | |
| 4d04 | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
| 1ayl | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.451 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.451 | |
| 2g8a | UMP | Thymidylate synthase | / | 0.450 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 1j7u | ANP | Aminoglycoside 3'-phosphotransferase | 2.7.1.95 | 0.448 | |
| 3bu5 | ATP | Insulin receptor | 2.7.10.1 | 0.448 | |
| 3dj4 | UD1 | Bifunctional protein GlmU | / | 0.447 | |
| 4c77 | N01 | Phenylacetone monooxygenase | 1.14.13.92 | 0.447 | |
| 5kcz | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 1a71 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1l7e | NAI | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.446 | |
| 1p9w | ANP | Type II secretion system protein E | / | 0.446 | |
| 1adc | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 5kje | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.445 | |
| 3av7 | KYN | Uncharacterized protein | / | 0.444 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.443 | |
| 3ake | C5P | Cytidylate kinase | / | 0.443 | |
| 1ih8 | APC | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.442 | |
| 3lgx | ATP | D-alanine--poly(phosphoribitol) ligase subunit 1 | / | 0.442 | |
| 3n0z | 3AT | Adenylate cyclase 2 | / | 0.442 | |
| 4dxh | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 5eom | CTP | Putative nucleotidyltransferase MAB21L1 | / | 0.442 | |
| 5kjf | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 2qr1 | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.441 | |
| 3m50 | EBT | 14-3-3-like protein C | / | 0.441 | |
| 3m50 | EBT | Plasma membrane ATPase | / | 0.441 | |
| 5ayz | NCN | Nicotinate-nucleotide pyrophosphorylase [carboxylating] | 2.4.2.19 | 0.441 | |
| 3oq6 | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.440 | |
| 5c1o | ANP | D-alanine--D-alanine ligase | / | 0.440 |