sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.647 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.647 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.645 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.640 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.640 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.636 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.635 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.628 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.627 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.624 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.622 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.621 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.621 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.620 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.617 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.611 | |
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 0.609 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.608 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.608 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.607 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.604 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.599 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.598 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.598 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.590 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.590 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.587 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.586 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.585 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.584 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.581 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.580 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.577 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.567 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.566 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.560 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.552 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.550 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.543 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.540 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.535 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.533 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.528 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.521 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.506 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.506 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.505 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.501 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.498 | |
| 1zdw | FLV | Prenyltransferase | / | 0.492 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.491 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.489 | |
| 1r2j | FAD | FkbI | / | 0.489 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.489 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.487 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.486 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.485 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.484 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.484 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.483 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.483 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.482 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.481 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.480 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.479 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.478 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.477 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.476 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.476 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.476 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.476 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.475 | |
| 4ocv | ANP | Aminoglycoside phosphotransferase | / | 0.475 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.474 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.474 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.474 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.473 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.473 | |
| 2wot | ZZG | TGF-beta receptor type-1 | 2.7.11.30 | 0.472 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.472 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.472 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.472 | |
| 4yr9 | NAD | L-threonine 3-dehydrogenase, mitochondrial | 1.1.1.103 | 0.472 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.472 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.471 | |
| 3to3 | ATP | Petrobactin biosynthesis protein AsbB | / | 0.471 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.470 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.469 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.469 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.468 | |
| 2uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.468 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.467 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.466 | |
| 2zjm | F1M | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 1fml | RTL | Retinol dehydratase | / | 0.465 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 3otq | MZL | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.465 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.465 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.464 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.464 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.464 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.464 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.464 | |
| 4dja | FAD | (6-4) photolyase | / | 0.464 | |
| 4elb | 34R | Dihydrofolate reductase | / | 0.464 | |
| 4hb9 | FAD | Uncharacterized protein | / | 0.464 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.463 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.463 | |
| 3jqp | A2P | Ferredoxin--NADP reductase, apicoplast | / | 0.463 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.463 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.462 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.462 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.462 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.462 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.462 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.462 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.462 | |
| 4uyf | 73B | Bromodomain-containing protein 2 | / | 0.462 | |
| 4wh3 | ATP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.462 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 1jra | FAD | FAD-linked sulfhydryl oxidase ERV2 | 1.8.3.2 | 0.461 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.461 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.461 | |
| 3t8v | BTJ | M1 family aminopeptidase | 3.4.11 | 0.461 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.461 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.461 | |
| 4ol0 | GTP | GTP-binding nuclear protein Ran | / | 0.461 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.460 | |
| 2ejz | SAH | Diphthine synthase | / | 0.460 | |
| 2g97 | DGB | Nicotinamide phosphoribosyltransferase | 2.4.2.12 | 0.460 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.460 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.460 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.459 | |
| 1dds | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1dhj | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.459 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.459 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.459 | |
| 3rdq | DTB | Streptavidin | / | 0.459 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.459 | |
| 3u33 | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.459 | |
| 4a84 | DXC | Major pollen allergen Bet v 1-A | / | 0.459 | |
| 4ele | 31I | Dihydrofolate reductase | / | 0.459 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.458 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2c0o | L2G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.458 | |
| 2zyn | BCD | Periplasmic binding protein | / | 0.458 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.458 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.458 | |
| 5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.458 | |
| 1fxs | NAP | GDP-L-fucose synthase | / | 0.457 | |
| 2bxq | IMN | Serum albumin | / | 0.457 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.457 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.457 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.457 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.456 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.456 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.456 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.456 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.456 | |
| 2xvw | 9NR | Serum albumin | / | 0.456 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.456 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 4elf | 35I | Dihydrofolate reductase | / | 0.456 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.455 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 2xvv | 9DN | Serum albumin | / | 0.455 | |
| 3arv | SAU | Chitinase A | / | 0.455 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.455 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.455 | |
| 3d7k | D7K | Benzaldehyde lyase | / | 0.455 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.455 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.455 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.454 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.454 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3b9l | AZZ | Serum albumin | / | 0.454 | |
| 4elb | 34S | Dihydrofolate reductase | / | 0.454 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.453 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.453 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.453 | |
| 1ek5 | NAD | UDP-glucose 4-epimerase | / | 0.452 | |
| 1lb9 | DNQ | Glutamate receptor 2 | / | 0.452 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.452 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.452 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.452 | |
| 1w1r | ZEA | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.452 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.452 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.452 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.452 | |
| 2r2n | KYN | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.452 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.452 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.452 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.452 | |
| 4kwh | NAP | Reductase homolog | / | 0.452 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.452 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1dxq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.451 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.451 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.451 | |
| 2zjw | REF | Casein kinase II subunit alpha | 2.7.11.1 | 0.451 | |
| 4g6h | NAI | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.451 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.451 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.450 | |
| 1rc4 | DDF | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.450 | |
| 1xkv | ATP | Phosphoenolpyruvate carboxykinase (ATP) | / | 0.450 | |
| 2ag1 | TPP | Benzaldehyde lyase | / | 0.450 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3fl9 | TOP | Dihydrofolate reductase | / | 0.450 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.450 | |
| 3lu1 | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.450 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.450 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.450 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.450 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.450 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.450 | |
| 5a3b | APR | SIR2 family protein | / | 0.450 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.450 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.449 | |
| 2d81 | RB3 | Poly(3-hydroxybutyrate) depolymerase | / | 0.449 | |
| 3ad9 | NAD | Subunit alpha of sarocosine oxidase | / | 0.449 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.449 | |
| 3zvm | ADP | Bifunctional polynucleotide phosphatase/kinase | 2.7.1.78 | 0.449 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4elg | 52J | Dihydrofolate reductase | / | 0.449 | |
| 4gyz | D5M | Tyrosyl-DNA phosphodiesterase 2 | 3.1.4 | 0.449 | |
| 4nxv | GDP | Mitochondrial dynamics protein MID51 | / | 0.449 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1dxo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1hnc | GDN | Glutathione S-transferase Mu 2 | 2.5.1.18 | 0.448 | |
| 1kqw | RTL | Cellular retinol-binding protein type II | / | 0.448 | |
| 1q20 | PLO | Sulfotransferase family cytosolic 2B member 1 | 2.8.2.2 | 0.448 | |
| 1syn | F89 | Thymidylate synthase | / | 0.448 | |
| 2pnc | CLU | Primary amine oxidase, liver isozyme | / | 0.448 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.448 | |
| 3e8x | NAP | BH1520 protein | / | 0.448 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.448 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.448 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.448 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.447 | |
| 2j9l | ATP | H(+)/Cl(-) exchange transporter 5 | / | 0.447 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.447 | |
| 2w6q | OA5 | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 3crz | FAD | Ferredoxin--NADP+ reductase | / | 0.447 | |
| 3ey9 | TDP | Pyruvate dehydrogenase [ubiquinone] | 1.2.5.1 | 0.447 | |
| 3w78 | CBD | FMN-dependent NADH-azoreductase | / | 0.447 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.447 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.447 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.447 | |
| 4u7w | NDP | MxaA | / | 0.447 | |
| 5ecc | NAP | Dehydrofolate reductase type I | / | 0.447 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.447 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.446 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.446 | |
| 2j5x | GSP | ADP-ribosylation factor 6 | / | 0.446 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.446 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.446 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.446 | |
| 3il1 | B5D | Glutamate receptor 2 | / | 0.446 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.446 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.446 | |
| 3ruc | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.446 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.446 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.446 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.446 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.446 | |
| 5jsc | FAD | Putative acyl-CoA dehydrogenase | / | 0.446 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.445 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.445 | |
| 2dte | NAI | Glucose 1-dehydrogenase related protein | / | 0.445 | |
| 2f7x | 4EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.445 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.445 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.445 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.445 | |
| 3klb | FMN | Uncharacterized protein | / | 0.445 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.445 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.445 | |
| 4xe6 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.445 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.444 | |
| 1n1e | NDE | Glycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal | 1.1.1.8 | 0.444 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2lba | CHO | Fatty acid binding protein 6 | / | 0.444 | |
| 2r59 | PH0 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.444 | |
| 2x3j | ATP | AcsD | / | 0.444 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.444 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.444 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.444 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.444 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.444 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4hxy | NDP | Plm1 | / | 0.444 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.444 | |
| 5doz | NDP | JamJ | / | 0.444 | |
| 5eai | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.444 | |
| 1c7o | PPG | Hemolysin | / | 0.443 | |
| 1g4t | FTP | Thiamine-phosphate synthase | / | 0.443 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.443 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.443 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.443 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.443 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.443 | |
| 2r8o | T5X | Transketolase 1 | / | 0.443 | |
| 2vwq | NAP | Glucose 1-dehydrogenase | / | 0.443 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.443 | |
| 3dey | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.443 | |
| 3fcj | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.443 | |
| 3klm | DHT | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3lu8 | IQX | Serum albumin | / | 0.443 | |
| 3qvi | K95 | HAP protein | / | 0.443 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.443 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.443 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4ffl | ADP | Uncharacterized protein | / | 0.443 | |
| 4ige | CHJ | Enoyl-acyl carrier reductase | / | 0.443 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.443 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.443 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 1g0n | NDP | Tetrahydroxynaphthalene reductase | 1.1.1.252 | 0.442 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.442 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 2rkv | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.442 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.442 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.442 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.442 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.442 | |
| 3r9u | FAD | Thioredoxin reductase | / | 0.442 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.442 | |
| 4e2b | FMN | Dehydrogenase | / | 0.442 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.442 | |
| 5c41 | ACP | Ribokinase | / | 0.442 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.441 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.441 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.441 | |
| 1rx8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.441 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.441 | |
| 2xsz | ATP | RuvB-like 2 | 3.6.4.12 | 0.441 | |
| 2zb3 | NDP | Prostaglandin reductase 2 | 1.3.1.48 | 0.441 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.441 | |
| 3h86 | AP5 | Adenylate kinase | / | 0.441 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.441 | |
| 3vry | B43 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.441 | |
| 3wag | TYD | Glycosyltransferase | / | 0.441 | |
| 4h6p | FMN | Chromate reductase | / | 0.441 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.441 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.441 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.441 | |
| 1ipe | NDP | Tropinone reductase 2 | 1.1.1.236 | 0.440 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.440 | |
| 2c59 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.440 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.440 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.440 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.440 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.440 | |
| 3a1n | NAD | NDP-sugar epimerase | / | 0.440 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.440 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.440 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3dds | 26B | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.440 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3eks | CY9 | Actin-5C | / | 0.440 | |
| 3gob | HXX | DdmC | / | 0.440 | |
| 3p9t | TCL | Repressor | / | 0.440 | |
| 3rue | NAD | UDP-N-acetylglucosamine 4-epimerase | / | 0.440 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.440 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4e0i | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.440 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.440 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.440 |