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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hxx1AYMethionine aminopeptidase 1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hxx1AYMethionine aminopeptidase 1/1.000
4iktTFVMethionine aminopeptidase 1/0.742
4fliY16Methionine aminopeptidase 1/0.707
4ikrPVPMethionine aminopeptidase 1/0.669
3pkeY10Methionine aminopeptidase 2/0.646
4ikuSHXMethionine aminopeptidase 1/0.639
2nq7HM5Methionine aminopeptidase 1/0.629
3iu7FCDMethionine aminopeptidase 2/0.627
2g6pHM2Methionine aminopeptidase 1/0.622
3pkdY10Methionine aminopeptidase 2/0.622
4fllYZ6Methionine aminopeptidase 1/0.621
2gg8U15Methionine aminopeptidase/0.619
2q94A04Methionine aminopeptidase/0.618
4flkY10Methionine aminopeptidase 1/0.617
2evcFC3Methionine aminopeptidase/0.607
3iu8T03Methionine aminopeptidase 2/0.607
3pkaY02Methionine aminopeptidase 2/0.607
2ggbU17Methionine aminopeptidase/0.605
4iksTFDMethionine aminopeptidase 1/0.605
2evmFC2Methionine aminopeptidase/0.600
3pkbY16Methionine aminopeptidase 2/0.599
2gg0U11Methionine aminopeptidase/0.594
3d27W29Methionine aminopeptidase/0.589
2q92B23Methionine aminopeptidase/0.583
4fljY08Methionine aminopeptidase 1/0.578
2q93B21Methionine aminopeptidase/0.575
2p98YE7Methionine aminopeptidase/0.573
1c23MPHMethionine aminopeptidase/0.563
2p99YE6Methionine aminopeptidase/0.559
2gg3U13Methionine aminopeptidase/0.556
2gg9U16Methionine aminopeptidase/0.554
2gg2U12Methionine aminopeptidase/0.553
3pkcY08Methionine aminopeptidase 2/0.552
1xnzFCDMethionine aminopeptidase/0.549
2q96A18Methionine aminopeptidase/0.541
1odcA8BAcetylcholinesterase3.1.1.70.539
2j3qTFLAcetylcholinesterase3.1.1.70.524
1qzyTDEMethionine aminopeptidase 2/0.519
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.519
2oazI96Methionine aminopeptidase 2/0.515
3iu9T07Methionine aminopeptidase 2/0.515
1zgbA1EAcetylcholinesterase3.1.1.70.511
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.511
1r5gAO1Methionine aminopeptidase 2/0.510
1vkgCRIHistone deacetylase 83.5.1.980.510
2w6cBM4Acetylcholinesterase3.1.1.70.510
2iyaZIOOleandomycin glycosyltransferase/0.502
1gaxVAAValine--tRNA ligase6.1.1.90.500
4b7zQ4QAcetylcholinesterase3.1.1.70.500
1r5hAO2Methionine aminopeptidase 2/0.499
1yw9A84Methionine aminopeptidase 2/0.499
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.499
4ey7E20Acetylcholinesterase3.1.1.70.498
1q84TZ4Acetylcholinesterase3.1.1.70.497
1r58AO5Methionine aminopeptidase 2/0.497
4to2DGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.497
2jf0HBPAcetylcholinesterase3.1.1.70.495
2qimZEAClass 10 plant pathogenesis-related protein/0.495
4rxrDCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.495
1h22E10Acetylcholinesterase3.1.1.70.494
2ea2F77Methionine aminopeptidase 2/0.494
2ea4F79Methionine aminopeptidase 2/0.494
4araC56Acetylcholinesterase3.1.1.70.494
2gmuPDGPutative pyridoxamine 5-phosphate-dependent dehydrase/0.493
4drn0MCPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.493
1zgcA2EAcetylcholinesterase3.1.1.70.492
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.492
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.492
1qtiGNTAcetylcholinesterase3.1.1.70.491
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.491
2xuhTZ4Acetylcholinesterase3.1.1.70.490
4kfqKFQGlutamate receptor ionotropic, NMDA 1/0.490
1yw8A75Methionine aminopeptidase 2/0.489
2oz57XYUncharacterized protein/0.489
2xupTZ5Acetylcholinesterase3.1.1.70.489
2xuiTZ5Acetylcholinesterase3.1.1.70.488
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.488
1jf0CZHObelin/0.487
2ct8MSPMethionine--tRNA ligase6.1.1.100.487
1yw7A41Methionine aminopeptidase 2/0.486
2xukTZ5Acetylcholinesterase3.1.1.70.486
2xuqTZ4Acetylcholinesterase3.1.1.70.486
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.486
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.486
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.485
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.485
2xufTZ4Acetylcholinesterase3.1.1.70.485
3wqmB29Diterpene synthase3.1.7.80.485
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.485
1v08NTZ4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.484
2ga2A19Methionine aminopeptidase 2/0.484
1eveE20Acetylcholinesterase3.1.1.70.483
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.483
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.483
4u163C0Muscarinic acetylcholine receptor M3/0.483
1ex75GPGuanylate kinase2.7.4.80.482
2g1r3IGRenin3.4.23.150.481
4m0f1YKAcetylcholinesterase3.1.1.70.481
2xugTZ4Acetylcholinesterase3.1.1.70.480
2xujTZ5Acetylcholinesterase3.1.1.70.480
4to6TTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.480
2ha6SCKAcetylcholinesterase3.1.1.70.479
2jl1NAPTriphenylmethane reductase/0.479
3rupADPBiotin carboxylase6.3.4.140.479
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.478
4ey6GNTAcetylcholinesterase3.1.1.70.478
2pb1NFGGlucan 1,3-beta-glucosidase/0.477
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.477
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.477
2xuoTZ4Acetylcholinesterase3.1.1.70.476
2g5w8PG12-oxophytodienoate reductase 31.3.1.420.475
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.475
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.475
4arbC57Acetylcholinesterase3.1.1.70.475
1u65CP0Acetylcholinesterase3.1.1.70.474
2gywOBIAcetylcholinesterase3.1.1.70.474
3e6eDCSAlanine racemase/0.474
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.474
1h60STRPentaerythritol tetranitrate reductase/0.473
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.473
2gv8NDPThiol-specific monooxygenase1.14.130.473
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.473
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.473
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.473
1dx6GNTAcetylcholinesterase3.1.1.70.472
2ckmAA7Acetylcholinesterase3.1.1.70.472
2g1y5IGRenin3.4.23.150.472
2gyuHI6Acetylcholinesterase3.1.1.70.472
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.472
1fkgSB3Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.471
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
1w6rGNTAcetylcholinesterase3.1.1.70.471
2g21L1BRenin3.4.23.150.471
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.471
4jtqNAPAldo-keto reductase family 1 member C2/0.471
1k4mNADNicotinate-nucleotide adenylyltransferase2.7.7.180.470
2g1o2IGRenin3.4.23.150.470
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.470
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.470
4isg1FYGlucokinase2.7.1.20.470
5cxv0HKMuscarinic acetylcholine receptor M1/0.470
2g1n1IGRenin3.4.23.150.469
2j83BATUlilysin3.4.240.469
3apwDP0Alpha-1-acid glycoprotein 2/0.469
3h7rNAPAldo-keto reductase family 4 member C8/0.469
3i0oSMISpectinomycin phosphotransferase/0.469
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.469
4kc1WS1Histo-blood group ABO system transferase/0.469
1obnASVIsopenicillin N synthase1.21.3.10.468
1qpf858Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.468
2aouCQAHistamine N-methyltransferase2.1.1.80.468
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.468
2xq0BESLeukotriene A-4 hydrolase homolog3.3.2.60.468
3q44D50M1 family aminopeptidase3.4.110.468
4id9NADPutative UDP-glucose 4-epimerase/0.468
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.468
1ut6A8NAcetylcholinesterase3.1.1.70.467
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.467
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.467
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.466
2ikuLIYRenin3.4.23.150.466
2wm3NFLNmrA-like family domain-containing protein 1/0.466
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.466
4dh0MR8Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.466
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.466
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.466
4to0DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.466
1ry0PG2Aldo-keto reductase family 1 member C3/0.465
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
2aovC2MHistamine N-methyltransferase2.1.1.80.465
2g263LGRenin3.4.23.150.465
2vq7NAPPutative flavin-containing monooxygenase/0.465
2xi4AFTAcetylcholinesterase3.1.1.70.465
3af1GDPPantothenate kinase2.7.1.330.465
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.465
4hcy0YNTransketolase/0.465
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.464
2cekN8TAcetylcholinesterase3.1.1.70.464
2vqbNAPPutative flavin-containing monooxygenase/0.464
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.464
4wdgA2P2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.464
1fkbRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.463
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.463
1w4lGL8Acetylcholinesterase3.1.1.70.463
1zisINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.463
2a4xBLMMitomycin-binding protein/0.463
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
2z4w749Geranylgeranyl pyrophosphate synthase/0.463
3u5ySCGRaucaffricine-O-beta-D-glucosidase3.2.1.1250.463
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.463
1p0pBCHCholinesterase3.1.1.80.462
2aotSAHHistamine N-methyltransferase2.1.1.80.462
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.462
2g247IGRenin3.4.23.150.462
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
3h0bB35Beta-secretase 13.4.23.460.462
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
4jq4IMNAldo-keto reductase family 1 member C2/0.462
4nv10FXFormyl transferase/0.462
5c3rHMUThymine dioxygenase/0.462
1q83TZ5Acetylcholinesterase3.1.1.70.461
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.461
3f8sPF2Dipeptidyl peptidase 4/0.461
3ufl508Beta-secretase 13.4.23.460.461
3zv7NHGAcetylcholinesterase3.1.1.70.461
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.461
4kbyC2EStimulator of interferon genes protein/0.461
1ja1FMNNADPH--cytochrome P450 reductase/0.460
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.460
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.460
3e78TPPHigh affinity transport system protein p37/0.460
4bfsZVSPantothenate kinase2.7.1.330.460
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.460
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.459
2bf4FADNADPH--cytochrome P450 reductase/0.459
2cdaNAPGlucose 1-dehydrogenase/0.459
2fznFADBifunctional protein PutA1.5.5.20.459
2jizANPATP synthase subunit beta, mitochondrial3.6.3.140.459
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.459
3k1wBFXRenin3.4.23.150.459
3mjrAC2Deoxycytidine kinase2.7.1.740.459
3oqfS51Renin3.4.23.150.459
3qe2FMNNADPH--cytochrome P450 reductase/0.459
4tnyDGTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.459
1e1fPSG4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic3.2.1.1820.458
1el4CTZObelin/0.458
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.458
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.458
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.458
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.458
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3v0o4GWHisto-blood group ABO system transferase/0.458
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.458
4jbsP52Endoplasmic reticulum aminopeptidase 23.4.110.458
4relKMPGlycosyltransferase/0.458
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.457
1qs2NADVip2Ac/0.457
1yumNCNProbable nicotinate-nucleotide adenylyltransferase2.7.7.180.457
2g226IGRenin3.4.23.150.457
2v19FMNDodecin/0.457
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.457
3rykTYDdTDP-4-dehydrorhamnose 3,5-epimerase/0.457
3t0iSAHPutative methyltransferase/0.457
3vyeVYERenin3.4.23.150.457
4bfq083Soluble acetylcholine receptor/0.457
4drhRAPSerine/threonine-protein kinase mTOR2.7.11.10.457
4drhRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.457
4e2yJHZMethyltransferase/0.457
4jsr1NQNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.457
4jt91NSNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.457
4mlp2CXCryptochrome-2/0.457
4phlPILPhosphodiesterase/0.457
5c1mCLRMu-type opioid receptor/0.457
1amoFMNNADPH--cytochrome P450 reductase/0.456
2a3bCFFEndochitinase B13.2.1.140.456
2g274LGRenin3.4.23.150.456
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.456
2wzySQXSoluble acetylcholine receptor/0.456
3c3xNAPEugenol synthase 11.1.1.3180.456
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.456
4q7f3D1Uncharacterized protein/0.456
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.456
5a4vQUEGlutathione S-transferase F22.5.1.180.456
1ja0FADNADPH--cytochrome P450 reductase/0.455
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.455
1o5gCR9Prothrombin3.4.21.50.455
2il2LIXRenin3.4.23.150.455
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.455
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.455
4bb2STRCorticosteroid-binding globulin/0.455
4wljIK2Kynurenine--oxoglutarate transaminase 12.6.1.70.455
4zwpM44Xaa-Pro dipeptidase3.4.13.90.455
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.454
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.454
1gr1FADFerredoxin--NADP reductase1.18.1.20.454
1pqc444Oxysterols receptor LXR-beta/0.454
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.454
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.454
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.454
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.454
3fvuIACKynurenine--oxoglutarate transaminase 12.6.1.70.454
3v2uATPProtein GAL3/0.454
4bftZVTPantothenate kinase2.7.1.330.454
4fam0SZAldo-keto reductase family 1 member C3/0.454
4n3r2GUTankyrase-12.4.2.300.454
4psbGA3Cytokinin-specific binding protein/0.454
4qfzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.454
4xmxBESAminopeptidase N3.4.11.20.454
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.454
4u140HKMuscarinic acetylcholine receptor M3/0.454
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.453
1esmCOAPantothenate kinase2.7.1.330.453
1gg5E09NAD(P)H dehydrogenase [quinone] 11.6.5.20.453
1gj4132Prothrombin3.4.21.50.453
1w76GNTAcetylcholinesterase3.1.1.70.453
3fhxPLPPyridoxal kinase2.7.1.350.453
3h3qH13Collagen type IV alpha-3-binding protein/0.453
3lzzGDPUncharacterized protein/0.453
3n71SFGHistone-lysine N-methyltransferase Smyd1/0.453
3r8hZOMAldo-keto reductase family 1 member C3/0.453
4q0kGA3Phytohormone-binding protein/0.453
1bl4AP1Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.452
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
1tllFMNNitric oxide synthase, brain1.14.13.390.452
2fahGDPPhosphoenolpyruvate carboxykinase [GTP], mitochondrial4.1.1.320.452
2fs4PZ1Renin3.4.23.150.452
3ab1FADFerredoxin--NADP reductase1.18.1.20.452
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.452
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.452
3n87N873-dehydroquinate dehydratase4.2.1.100.452
3nx2FERFerulic acid decarboxylase/0.452
3q43D66M1 family aminopeptidase3.4.110.452
3w78CBDFMN-dependent NADH-azoreductase/0.452
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.452
4dbw511Aldo-keto reductase family 1 member C3/0.452
4f0rMTA5-methylthioadenosine/S-adenosylhomocysteine deaminase/0.452
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.452
4gd40WSLysine-specific demethylase 4A1.14.110.452
7stdCRPScytalone dehydratase4.2.1.940.452
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.451
2bn4FMNNADPH--cytochrome P450 reductase/0.451
2cbqTH2Neocarzinostatin/0.451
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
3oqkS52Renin3.4.23.150.451
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.451
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
4cdmFO1Deoxyribodipyrimidine photolyase/0.451
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.451
4iarERM5-hydroxytryptamine receptor 1B/0.451
1nl4HFPProtein farnesyltransferase subunit beta2.5.1.580.450
1qpl587Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.450
1wopFFOAminomethyltransferase/0.450
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
1z6tADPApoptotic protease-activating factor 1/0.450
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.450
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.450
3af0GDPPantothenate kinase2.7.1.330.450
3b6pTMPThree-prime repair exonuclease 13.1.11.20.450
3fsjD7KBenzoylformate decarboxylase4.1.1.70.450
3gwfNAPCyclohexanone monooxygenase/0.450
3h3r14HCollagen type IV alpha-3-binding protein/0.450
3qj0QI3Botulinum neurotoxin type A3.4.24.690.450
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3v0p4GWHisto-blood group ABO system transferase/0.450
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.450
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.449
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.449
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2bf4FMNNADPH--cytochrome P450 reductase/0.449
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.449
2futH1SHeparin and heparin-sulfate lyase/0.449
2getCOKPantothenate kinase2.7.1.330.449
2jgbMGTEukaryotic translation initiation factor 4E type 2/0.449
2rqfJH3Hemolymph juvenile hormone binding protein/0.449
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3dr7GPDGDP-perosamine synthase/0.449
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.449
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3rvhHQ2Lysine-specific demethylase 4A1.14.110.449
4a86H35Major pollen allergen Bet v 1-A/0.449
4gaaBESLeukotriene A(4) hydrolase/0.449
4kc2WS2Histo-blood group ABO system transferase/0.449
4nv1TYDFormyl transferase/0.449
1gj5130Prothrombin3.4.21.50.448
1i9c5ADGlutamate mutase epsilon subunit/0.448
1kruIPTGalactoside O-acetyltransferase2.3.1.180.448
1mxfMTXPutative pteridine reductase 2/0.448
2vqzMGTPolymerase basic protein 2/0.448
3casASD3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
3jusBCDLanosterol 14-alpha demethylase1.14.13.700.448
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.448
3nwlNDPCatalase1.11.1.60.448
3oadLPORenin3.4.23.150.448
3s8pSAMHistone-lysine N-methyltransferase KMT5B2.1.1.430.448
3t8vBTJM1 family aminopeptidase3.4.110.448
3ug8IMNAldo-keto reductase family 1 member C3/0.448
4djx0KQBeta-secretase 13.4.23.460.448
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4lutDCSAlanine racemase/0.448
1b8oIMHPurine nucleoside phosphorylase2.4.2.10.447
1c7oPPGHemolysin/0.447
1gt5BZQOdorant-binding protein/0.447
1kwcBPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.447
1w6jR71Lanosterol synthase5.4.99.70.447
2r59PH0Leukotriene A-4 hydrolase3.3.2.60.447
2v58LZJBiotin carboxylase6.3.4.140.447
2xlpFADPutative flavin-containing monooxygenase/0.447
3w3lRX8Toll-like receptor 8/0.447
3zbzOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.447
4m0cFMNFMN-dependent NADH-azoreductase 1/0.447
1akaPLPAspartate aminotransferase, mitochondrial2.6.1.10.446
1jwtBLIProthrombin3.4.21.50.446
1rftPXMPyridoxal kinase2.7.1.350.446
2aot2PMHistamine N-methyltransferase2.1.1.80.446
2fzmFADBifunctional protein PutA1.5.5.20.446
2g1s4IGRenin3.4.23.150.446
2pncCLUPrimary amine oxidase, liver isozyme/0.446
2wcgMT5Glucosylceramidase3.2.1.450.446
2xjc5GPCytosolic purine 5'-nucleotidase3.1.3.50.446
2xytTC9Soluble acetylcholine receptor/0.446
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.446
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3fktSIIBeta-secretase 13.4.23.460.446
3ix8TX3Transcriptional activator protein LasR/0.446
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3wagTYDGlycosyltransferase/0.446
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.446
4b66NAPL-ornithine N(5)-monooxygenase/0.446
4e32DWNMethyltransferase/0.446
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4to3DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.446
5stdUNNScytalone dehydratase4.2.1.940.446
1fklRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.445
1gvrTNLPentaerythritol tetranitrate reductase/0.445
1re0AFBADP-ribosylation factor 1/0.445
1re0AFBARF guanine-nucleotide exchange factor 1/0.445
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
1x1bSAHC-20 methyltransferase/0.445
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.445
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
3akn11DFatty acid-binding protein, intestinal/0.445
3f6sFMNFlavodoxin/0.445
3frkTQPQdtB/0.445
3gncQQQGlutaryl-CoA dehydrogenase/0.445
4diqPD2Ribosomal oxygenase 1/0.445
4x7wMVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.445
2ycxP32Beta-1 adrenergic receptor/0.445
1c9hRAPPeptidyl-prolyl cis-trans isomerase FKBP1B5.2.1.80.444
2fkeFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.444
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2ipiAKYAclacinomycin-N/aclacinomycin-A oxidase/0.444
2whqHI6Acetylcholinesterase3.1.1.70.444
2yd0BESEndoplasmic reticulum aminopeptidase 13.4.110.444
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3mj4URMUDP-galactopyranose mutase/0.444
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.444
3rthRTHBeta-secretase 13.4.23.460.444
3ugrIMNAldo-keto reductase family 1 member C3/0.444
3v0m5GWHisto-blood group ABO system transferase/0.444
4a6rTA8Probable aminotransferase/0.444
4driRAPSerine/threonine-protein kinase mTOR2.7.11.10.444
4driRAPPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.444
4qzuRTLRetinol-binding protein 2/0.444
4y17LAETranscriptional regulator of ftsQAZ gene cluster/0.444
5dp2NAPCurF/0.444
5iefNBVNeutral alpha-glucosidase AB3.2.1.840.444
1by5GLY_GLY_GLY_AHO_AHO_AHO_FEFerrichrome-iron receptor/0.443
2g25TDKPyruvate dehydrogenase E1 component1.2.4.10.443
3af4GCPPantothenate kinase2.7.1.330.443
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3k7mFAD6-hydroxy-L-nicotine oxidase/0.443
3myuVIBHigh affinity transport system protein p37/0.443
3rsv3RSBeta-secretase 13.4.23.460.443
3rtnRTNBeta-secretase 13.4.23.460.443
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.443
3u57DH8Raucaffricine-O-beta-D-glucosidase3.2.1.1250.443
3uxvGUNNADPH-dependent 7-cyano-7-deazaguanine reductase/0.443
4c13UMLUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase/0.443
4drm0MCPeptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.443
4dxlC5P4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.443
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.443
4to1DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.443
4uugPXGBranched-chain amino acid aminotransferase, putative/0.443
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.442
1queFADFerredoxin--NADP reductase1.18.1.20.442
1rfuPLPPyridoxal kinase2.7.1.350.442
1waj5GPDNA-directed DNA polymerase/0.442
2b58COADiamine acetyltransferase 1/0.442
2hzqSTRApolipoprotein D/0.442
2idvM7GEukaryotic translation initiation factor 4E-1/0.442
2nm2NEUDihydroneopterin aldolase/0.442
2ouyCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
2piaFMNPhthalate dioxygenase reductase/0.442
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.442
3btjDEQHTH-type transcriptional regulator QacR/0.442
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.442
4bfvZVVPantothenate kinase2.7.1.330.442
4fhd0TTSpore photoproduct lyase/0.442
4gddNAIUDP-galactopyranose mutase/0.442
4jpg1OXPyruvate kinase PKM2.7.1.400.442
4k5o1OTM1 family aminopeptidase3.4.110.442
1dghNDPCatalase1.11.1.60.441
1gky5GPGuanylate kinase2.7.4.80.441
1h66RH1NAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1jedADPSulfate adenylyltransferase/0.441
1jqdSAHHistamine N-methyltransferase2.1.1.80.441
1l8qADPChromosomal replication initiator protein DnaA/0.441
2w6pOA4Biotin carboxylase6.3.4.140.441
2yj5ATPCopper-transporting ATPase/0.441
3c1oNAPEugenol synthase/0.441
3d91REMRenin3.4.23.150.441
3uyk0CXProbable NDP-rhamnosyltransferase/0.441
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.441
4d6qPD2Lysine-specific demethylase 4D1.14.110.441
4lcnGNGCytidine and deoxycytidylate deaminase zinc-binding region/0.441
4rxqDUTDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.441
4s1iPLPPyridoxal kinase, putative/0.441
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.441
1digL37C-1-tetrahydrofolate synthase, cytoplasmic1.5.1.50.440
1fkiSB1Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
1fwyUD1Bifunctional protein GlmU/0.440
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
1pfyMSPMethionine--tRNA ligase6.1.1.100.440
1q23FUAChloramphenicol acetyltransferase2.3.1.280.440
1umlFR4Adenosine deaminase3.5.4.40.440
1ve3SAMUncharacterized protein/0.440
1vfsDCSAlanine racemase/0.440
2y1x845Histone-arginine methyltransferase CARM1/0.440
3b1dPLSBetaC-S lyase/0.440
3bjcWANcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
3g70A5TRenin3.4.23.150.440
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.440
3gwfFADCyclohexanone monooxygenase/0.440
3i7vB4PAP4A hydrolase/0.440
3nytULPUDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.440
3o5rFK5Peptidyl-prolyl cis-trans isomerase FKBP55.2.1.80.440
3qeoLLTDeoxycytidine kinase2.7.1.740.440
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.440
4b68NAPL-ornithine N(5)-monooxygenase/0.440
4n1gCEIObelin/0.440
5ah5LSSLeucine--tRNA ligase/0.440
5erm210Fusicoccadiene synthase4.2.3.430.440