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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hqvQEIQueuine tRNA-ribosyltransferase2.4.2.29

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hqvQEIQueuine tRNA-ribosyltransferase2.4.2.291.000
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.693
4gcxPRFQueuine tRNA-ribosyltransferase2.4.2.290.693
4hshQEIQueuine tRNA-ribosyltransferase2.4.2.290.637
4hvxQEIQueuine tRNA-ribosyltransferase2.4.2.290.621
3bllBPQQueuine tRNA-ribosyltransferase2.4.2.290.614
4h7zGUNQueuine tRNA-ribosyltransferase2.4.2.290.593
3bloQEIQueuine tRNA-ribosyltransferase2.4.2.290.590
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.290.568
2z1wBDIQueuine tRNA-ribosyltransferase2.4.2.290.556
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.551
3bldPRFQueuine tRNA-ribosyltransferase2.4.2.290.544
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.542
4fsa0V3Queuine tRNA-ribosyltransferase2.4.2.290.516
2e99B08Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.515
1q63AIQQueuine tRNA-ribosyltransferase2.4.2.290.504
4twnB96Ephrin type-A receptor 32.7.10.10.499
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.496
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.494
1efzPRFQueuine tRNA-ribosyltransferase2.4.2.290.492
2z2w770Wee1-like protein kinase2.7.10.20.492
2in6839Wee1-like protein kinase2.7.10.20.491
4fps0UXQueuine tRNA-ribosyltransferase2.4.2.290.491
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.490
1pxgPRFQueuine tRNA-ribosyltransferase2.4.2.290.488
1x8b824Wee1-like protein kinase2.7.10.20.486
2io6330Wee1-like protein kinase2.7.10.20.484
2xk730ESerine/threonine-protein kinase Nek22.7.11.10.484
4gg90WWQueuine tRNA-ribosyltransferase2.4.2.290.483
1k4hAPQQueuine tRNA-ribosyltransferase2.4.2.290.482
3biz61EWee1-like protein kinase2.7.10.20.481
2vcmM11Isopenicillin N synthase1.21.3.10.480
3zkyWT4Isopenicillin N synthase1.21.3.10.479
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.479
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.477
3arvSAUChitinase A/0.477
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.477
1synF89Thymidylate synthase/0.476
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.476
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.476
3s7a684Dihydrofolate reductase1.5.1.30.475
4kebFOLDihydrofolate reductase1.5.1.30.475
1hfrMOTDihydrofolate reductase1.5.1.30.474
1q6nP90Tyrosine-protein phosphatase non-receptor type 13.1.3.480.472
3zsh469Mitogen-activated protein kinase 14/0.472
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.472
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.472
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.471
2bbf344Queuine tRNA-ribosyltransferase2.4.2.290.471
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.471
4a4o664Serine/threonine-protein kinase PLK12.7.11.210.471
4bj9UHBTankyrase-22.4.2.300.471
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.471
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.470
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.470
4dju0KKBeta-secretase 13.4.23.460.470
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.470
1ej3CZHAequorin-2/0.469
2rl1UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.469
3sni546cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.468
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.468
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.468
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.467
2dhfDZFDihydrofolate reductase1.5.1.30.467
3lfeZ84Mitogen-activated protein kinase 14/0.467
3nrrD16Bifunctional dihydrofolate reductase-thymidylate synthase/0.467
2fjm073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.466
2w6zL21Biotin carboxylase6.3.4.140.466
2xkc4VQSerine/threonine-protein kinase Nek22.7.11.10.466
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.466
1ove358Mitogen-activated protein kinase 14/0.465
2x9vTMQPteridine reductase/0.465
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.465
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.465
2clfF6FTryptophan synthase alpha chain/0.464
2pulACPMethylthioribose kinase2.7.1.1000.464
3cr0809Wee1-like protein kinase2.7.10.20.464
3upkUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.464
2vd0D27Hematopoietic prostaglandin D synthase/0.463
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.463
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.462
1qv0CZHObelin/0.462
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.462
1pkfEPDEpothilone C/D epoxidase1.140.461
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.461
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.461
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.461
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.461
4iilRBFMembrane lipoprotein TpN38(b)/0.461
1dr4HBIDihydrofolate reductase1.5.1.30.460
1hfqMOTDihydrofolate reductase1.5.1.30.460
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.460
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.460
4ajgF07cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.459
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.459
2w3aTOPDihydrofolate reductase1.5.1.30.459
3rfmCFFAdenosine receptor A2a/0.459
3eon341Glutaryl-CoA dehydrogenase/0.458
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
3zoiM2WIsopenicillin N synthase1.21.3.10.458
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.458
4djw0KPBeta-secretase 13.4.23.460.458
4f3gKAIGlutamate receptor 3/0.458
1s7gNADNAD-dependent protein deacylase 2/0.457
2xkfBX1Serine/threonine-protein kinase Nek22.7.11.10.457
3gncQQQGlutaryl-CoA dehydrogenase/0.457
3nxoD2BDihydrofolate reductase1.5.1.30.457
4j521J3Serine/threonine-protein kinase PLK12.7.11.210.457
4ybnFADFlavin-nucleotide-binding protein/0.457
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.456
2bfmTOPPteridine reductase 11.5.1.330.456
2cleF6FTryptophan synthase alpha chain/0.456
3kr6UD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.456
4ddl0JQcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.456
4h380YXDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.456
4kbn25UDihydrofolate reductase1.5.1.30.456
5dp2NAPCurF/0.456
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.455
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.455
2obxINI6,7-dimethyl-8-ribityllumazine synthase 22.5.1.780.455
4b78KGGBeta-secretase 13.4.23.460.455
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.455
1ao8MTXDihydrofolate reductase1.5.1.30.454
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2c4cFAD[F-actin]-methionine sulfoxide oxidase MICAL11.14.130.454
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.454
2olcADPMethylthioribose kinase2.7.1.1000.454
1s3uTQDDihydrofolate reductase1.5.1.30.453
2xk4OL2Serine/threonine-protein kinase Nek22.7.11.10.453
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
4k9yK9YFocal adhesion kinase 12.7.10.20.453
4m6kFOLDihydrofolate reductase1.5.1.30.453
1rx5DDFDihydrofolate reductase1.5.1.30.452
2ovvPFHcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
2w3mFOLDihydrofolate reductase1.5.1.30.452
3gyf51PDihydrofolate reductase1.5.1.30.452
3htjETEbrA repressor/0.452
3hv3R49Mitogen-activated protein kinase 14/0.452
3jqgAX6Pteridine reductase, putative/0.452
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.452
4a99MIYTetX family tetracycline inactivation enzyme/0.452
4b6l9ZPSerine/threonine-protein kinase PLK32.7.11.210.452
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
4bwaN0BPyrrolysine--tRNA ligase/0.452
4iarERM5-hydroxytryptamine receptor 1B/0.452
5d7pOCZNAD-dependent protein deacetylase sirtuin-23.5.10.452
1zzlTZYMitogen-activated protein kinase 14/0.451
2yac937Serine/threonine-protein kinase PLK12.7.11.210.451
3h1vTK1Glucokinase2.7.1.20.451
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.451
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.451
1bzfTMQDihydrofolate reductase1.5.1.30.450
1fw0KAIGlutamate receptor 2/0.450
1q6s214Tyrosine-protein phosphatase non-receptor type 13.1.3.480.450
1tsdF89Thymidylate synthase/0.450
1xddAAYIntegrin alpha-L/0.450
2ydoADNAdenosine receptor A2a/0.450
3itzP66Mitogen-activated protein kinase 14/0.450
4g1nNZTPyruvate kinase PKM2.7.1.400.450
5bn3ADPV-type ATP synthase alpha chain/0.450
5bn3ADPNEQ263/0.450
1hfpMOTDihydrofolate reductase1.5.1.30.449
1krv147Galactoside O-acetyltransferase2.3.1.180.449
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
2qzrS79Queuine tRNA-ribosyltransferase2.4.2.290.449
3iktNADRedox-sensing transcriptional repressor Rex/0.449
3jyqNADQuinate/shikimate dehydrogenase (NAD(+))/0.449
4e0u0MVCyclic dipeptide N-prenyltransferase/0.449
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
1t13INI6,7-dimethyl-8-ribityllumazine synthase 2/0.448
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.448
2w6qOA5Biotin carboxylase6.3.4.140.448
3gcq1BUMitogen-activated protein kinase 14/0.448
3h3t16HCollagen type IV alpha-3-binding protein/0.448
3n0cFADFlavin-dependent thymidylate synthase2.1.1.1480.448
3oafOAGDihydrofolate reductase1.5.1.30.448
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.448
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.448
4h1e10JBeta-secretase 13.4.23.460.448
3uzaT4GAdenosine receptor A2a/0.448
1axwMTXThymidylate synthase/0.447
1kruIPTGalactoside O-acetyltransferase2.3.1.180.447
2a9z26AAdenosine kinase2.7.1.200.447
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
2x7hPFNProstaglandin reductase 310.447
3jypNADQuinate/shikimate dehydrogenase (NAD(+))/0.447
3x04GNPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.447
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.447
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
1odjGMPPurine nucleoside phosphorylase/0.446
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
4b6uM7GEukaryotic translation initiation factor 4E type 3/0.446
4djx0KQBeta-secretase 13.4.23.460.446
4edz0O5Hematopoietic prostaglandin D synthase/0.446
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.446
4j6dTESCytochrome P450 monooxygenase/0.446
4jlj1NMDeoxycytidine kinase2.7.1.740.446
1blzACVIsopenicillin N synthase1.21.3.10.445
1qv1CZHObelin/0.445
1uzwCDHIsopenicillin N synthase1.21.3.10.445
1w7h3IPMitogen-activated protein kinase 14/0.445
2jb4A14Isopenicillin N synthase1.21.3.10.445
2punACPMethylthioribose kinase2.7.1.1000.445
2qcxPF1Aminopyrimidine aminohydrolase/0.445
3ba6AN2Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.445
3d4bDZDNAD-dependent protein deacetylase/0.445
3fl4FL4Mitogen-activated protein kinase 14/0.445
3l3rOAGDihydrofolate reductase1.5.1.30.445
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.445
4ea2RWZDehydrosqualene synthase/0.445
4fhd0TTSpore photoproduct lyase/0.445
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.445
4jlm1NNDeoxycytidine kinase2.7.1.740.445
4y1bNAPAntE/0.445
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2bu9HFVIsopenicillin N synthase1.21.3.10.444
2vbpVB1Isopenicillin N synthase1.21.3.10.444
3hziATPSerine/threonine-protein kinase toxin HipA/0.444
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3lfzADPUncharacterized protein MJ1225/0.444
4equG6ISerine/threonine-protein kinase 102.7.11.10.444
4q15HFGProline--tRNA ligase6.1.1.150.444
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.444
1ry0PG2Aldo-keto reductase family 1 member C3/0.443
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
3qeoLLTDeoxycytidine kinase2.7.1.740.443
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4h3i10VBeta-secretase 13.4.23.460.443
4j531J4Serine/threonine-protein kinase PLK12.7.11.210.443
5cc9DDFDihydrofolate reductase1.5.1.30.443
5fsxADPUncharacterized protein/0.443
1dlsMTXDihydrofolate reductase1.5.1.30.442
1e92HBIPteridine reductase 11.5.1.330.442
1j3jCP6Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.442
2fhjH4ZFormylmethanofuran--tetrahydromethanopterin formyltransferase2.3.1.1010.442
2gfsPQBMitogen-activated protein kinase 14/0.442
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
3b4yF42F420-dependent glucose-6-phosphate dehydrogenase/0.442
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.442
4ixc1JDGlucokinase2.7.1.20.442
1bk0ACVIsopenicillin N synthase1.21.3.10.441
1bozPRDDihydrofolate reductase1.5.1.30.441
1dr3HBIDihydrofolate reductase1.5.1.30.441
1yqj6NPMitogen-activated protein kinase 14/0.441
1zq5E04Aldo-keto reductase family 1 member C3/0.441
2bf4FMNNADPH--cytochrome P450 reductase/0.441
2bktRPFRenin3.4.23.150.441
2fjn073Tyrosine-protein phosphatase non-receptor type 13.1.3.480.441
2wqoVGKSerine/threonine-protein kinase Nek22.7.11.10.441
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3irm1CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3k4551PDihydrofolate reductase1.5.1.30.441
3oqkS52Renin3.4.23.150.441
3pm1ETHTH-type transcriptional regulator QacR/0.441
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.441
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.440
1fgiSU1Fibroblast growth factor receptor 1/0.440
1ne4RP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.440
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
2y60M8FIsopenicillin N synthase1.21.3.10.440
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.440
4da6GA2Purine nucleoside phosphorylase DeoD-type2.4.2.10.440
4tjy3GNTankyrase-22.4.2.300.440
4u0mGTPCyclic GMP-AMP synthase/0.440
4z87GDPInosine-5'-monophosphate dehydrogenase/0.440
5iubCLRAdenosine receptor A2a/0.440
3qakUKAAdenosine receptor A2a/0.440