Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hni16WCasein kinase I isoform epsilon2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hni16WCasein kinase I isoform epsilon2.7.11.11.000
3uyt0CKCasein kinase I isoform delta2.7.11.10.549
4hnf16WCasein kinase I isoform delta2.7.11.10.528
4i22IREEpidermal growth factor receptor2.7.10.10.516
4kbk1QGCasein kinase I isoform delta2.7.11.10.513
4kbc1QJCasein kinase I isoform delta2.7.11.10.510
4fnyI3KALK tyrosine kinase receptor2.7.10.10.509
3uzp0CKCasein kinase I isoform delta2.7.11.10.500
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.499
2jedLG8Protein kinase C theta type2.7.11.130.493
4kb81QNCasein kinase I isoform delta2.7.11.10.492
4kba1QMCasein kinase I isoform delta2.7.11.10.491
4yuqKS1Calmodulin-like domain protein kinase/0.489
2ittAEEEpidermal growth factor receptor2.7.10.10.488
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.488
3pwhZMAAdenosine receptor A2a/0.488
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
3gc9B45Mitogen-activated protein kinase 112.7.11.240.484
3a4pDFQHepatocyte growth factor receptor2.7.10.10.483
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.482
4k9yK9YFocal adhesion kinase 12.7.10.20.482
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.478
2j0k4STFocal adhesion kinase 12.7.10.20.478
3w33W19Epidermal growth factor receptor2.7.10.10.478
1xjdSTUProtein kinase C theta type2.7.11.130.476
2wotZZGTGF-beta receptor type-12.7.11.300.475
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.475
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.474
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.474
3iw4LW4Protein kinase C alpha type2.7.11.130.472
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.472
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.471
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.471
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.471
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.470
1ywrLI9Mitogen-activated protein kinase 14/0.469
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.469
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.468
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.468
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
3w32W32Epidermal growth factor receptor2.7.10.10.468
4dymIYZActivin receptor type-12.7.11.300.468
4jq8KJ8Epidermal growth factor receptor2.7.10.10.468
4loqSB4Mitogen-activated protein kinase 14/0.468
1j3kWRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.467
3rfmCFFAdenosine receptor A2a/0.467
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.466
3mtfA3FActivin receptor type-12.7.11.300.466
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.466
4riyADPEpidermal growth factor receptor2.7.10.10.466
3e5aVX6Aurora kinase A2.7.11.10.465
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.465
3vs1VSATyrosine-protein kinase HCK2.7.10.20.465
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.465
4c02TAKActivin receptor type-12.7.11.300.465
5e8wSTUTGF-beta receptor type-12.7.11.300.465
3fln3FNMitogen-activated protein kinase 14/0.464
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.464
4h9753SDihydrofolate reductase1.5.1.30.464
4othDRNSerine/threonine-protein kinase N1/0.464
2chlDKICasein kinase I isoform gamma-32.7.11.10.463
3jsuKA5Bifunctional dihydrofolate reductase-thymidylate synthase/0.463
4i41MIXSerine/threonine-protein kinase pim-12.7.11.10.463
4jrvKJVEpidermal growth factor receptor2.7.10.10.463
1m17AQ4Epidermal growth factor receptor2.7.10.10.462
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
4fv9E71Mitogen-activated protein kinase 12.7.11.240.462
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.462
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.462
1u54ACPActivated CDC42 kinase 1/0.461
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.461
3wv9FEGHmd co-occurring protein HcgE/0.461
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.461
1e6eFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.460
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.460
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.460
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.460
2izrBRKCasein kinase I isoform gamma-32.7.11.10.460
4ixfIXFDihydrofolate reductase1.5.1.30.460
3a60STURibosomal protein S6 kinase beta-12.7.11.10.459
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.458
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.458
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.458
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.458
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.458
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.458
3reyXACAdenosine receptor A2a/0.458
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.457
3zewSTUEphrin type-B receptor 42.7.10.10.457
4jlk1NODeoxycytidine kinase2.7.1.740.457
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.457
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.456
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.456
4ewqMWLMitogen-activated protein kinase 14/0.456
4gg70J8Hepatocyte growth factor receptor2.7.10.10.456
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.456
4xe606UDihydrofolate reductase1.5.1.30.456
1wvxBD4Death-associated protein kinase 12.7.11.10.455
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.455
3zh8C58Protein kinase C iota type2.7.11.130.455
4bchT7ZCyclin-dependent kinase 92.7.11.220.455
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.455
5f0a1FBcGMP-dependent protein kinase, putative/0.455
2z78H86Geranylgeranyl pyrophosphate synthase/0.454
4bgg844Activin receptor type-12.7.11.300.454
4fuxE75Mitogen-activated protein kinase 12.7.11.240.454
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.454
4jr3KJREpidermal growth factor receptor2.7.10.10.454
1bygSTUTyrosine-protein kinase CSK/0.453
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.453
2ckeIQUDeath-associated protein kinase 2/0.453
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.453
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.453
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.453
3x0a5GPPhosphatidylinositol 5-phosphate 4-kinase type-2 beta2.7.1.1490.453
1fgiSU1Fibroblast growth factor receptor 1/0.452
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
3oqkS52Renin3.4.23.150.452
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.452
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4ic7ANPMitogen-activated protein kinase 72.7.11.240.452
4j6cSTRCytochrome P450 monooxygenase/0.452
4iarERM5-hydroxytryptamine receptor 1B/0.451
4ib4ERM5-hydroxytryptamine receptor 2B/0.451
1tqpATPRIO-type serine/threonine-protein kinase Rio22.7.11.10.450
2w3vTOPDihydrofolate reductase/0.450
3tubFPUTyrosine-protein kinase SYK2.7.10.20.450
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.450
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
4j6dTESCytochrome P450 monooxygenase/0.450
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.450
3uzcT4EAdenosine receptor A2a/0.450
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.449
3tucFPWTyrosine-protein kinase SYK2.7.10.20.449
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.449
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.448
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.448
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.448
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.448
4hgt15GCasein kinase I isoform delta2.7.11.10.448
4twpAXITyrosine-protein kinase ABL12.7.10.20.448
4xhgADPUncharacterized protein/0.448
1drbMTXDihydrofolate reductase1.5.1.30.447
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.447
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.447
3qly55VUncharacterized protein/0.447
3r02UNMSerine/threonine-protein kinase pim-12.7.11.10.447
4a7cE46Serine/threonine-protein kinase pim-12.7.11.10.447
4bcqTJFCyclin-dependent kinase 22.7.11.220.447
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.447
4em9TCEPeroxisome proliferator-activated receptor gamma/0.447
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4gk4L90Ephrin type-A receptor 32.7.10.10.447
1cd2FOLDihydrofolate reductase1.5.1.30.446
1csnATPCasein kinase I homolog 12.7.11.10.446
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
3hl7I47Mitogen-activated protein kinase 14/0.446
3hvcGG5Mitogen-activated protein kinase 14/0.446
3tq9MTXDihydrofolate reductase/0.446
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.446
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.446
3zsgT75Mitogen-activated protein kinase 14/0.446
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.446
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.446
4jq7KJQEpidermal growth factor receptor2.7.10.10.446
1siqFADGlutaryl-CoA dehydrogenase, mitochondrial1.3.8.60.445
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2fziDH3Dihydrofolate reductase1.5.1.30.445
2x7gPVBSRSF protein kinase 22.7.11.10.445
3a62STURibosomal protein S6 kinase beta-12.7.11.10.445
3k1wBFXRenin3.4.23.150.445
3kf7L9GMitogen-activated protein kinase 14/0.445
4a4l939Serine/threonine-protein kinase PLK12.7.11.210.445
4aacAAVMitogen-activated protein kinase 14/0.445
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.445
4jbtASDCytochrome P450 monooxygenase/0.445
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.445
1ir3ANPInsulin receptor2.7.10.10.444
1w7kADPDihydrofolate synthase/folylpolyglutamate synthase6.3.2.120.444
2fzhDH1Dihydrofolate reductase1.5.1.30.444
3cv9VDXVitamin D3 dihydroxylase/0.444
3q5iANPProtein kinase, putative/0.444
4ele31IDihydrofolate reductase/0.444
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.444
4kaoKAOFocal adhesion kinase 12.7.10.20.444
2itqITQEpidermal growth factor receptor2.7.10.10.443
3hllI45Mitogen-activated protein kinase 14/0.443
4b8mVX6Aurora kinase B-A2.7.11.10.443
4lopSB4Mitogen-activated protein kinase 14/0.443
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.442
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.442
2csnCKICasein kinase I homolog 12.7.11.10.442
2itpAEEEpidermal growth factor receptor2.7.10.10.442
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.442
3ogqAB1Pol polyprotein/0.442
3roc29AMitogen-activated protein kinase 14/0.442
3w2sW2REpidermal growth factor receptor2.7.10.10.442
4kb81QOCasein kinase I isoform delta2.7.11.10.442
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
1ddrMTXDihydrofolate reductase1.5.1.30.441
2b365PPEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.441
2ph5NADHomospermidine synthase/0.441
2vf0F89Thymidylate synthase/0.441
3poz03PEpidermal growth factor receptor2.7.10.10.441
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.441
4nc3ERM5-hydroxytryptamine receptor 2B/0.441
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.441
2uzlC94Cyclin-dependent kinase 22.7.11.220.440
3p6oETGCamphor 5-monooxygenase1.14.15.10.440
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.440
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.440