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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hkiFLNTankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hkiFLNTankyrase-22.4.2.301.000
4avwG18Tankyrase-22.4.2.300.722
4buuF38Tankyrase-22.4.2.300.712
4buiW2ETankyrase-22.4.2.300.706
4bufF36Tankyrase-22.4.2.300.697
4l33F70Tankyrase-22.4.2.300.680
5aku29FTankyrase-22.4.2.300.676
4buv16ITankyrase-22.4.2.300.671
4bu908CTankyrase-22.4.2.300.665
4but31FTankyrase-22.4.2.300.664
4l0s1UZTankyrase-22.4.2.300.660
4hlk431Tankyrase-22.4.2.300.653
4hlg20BTankyrase-22.4.2.300.637
4buxF35Tankyrase-22.4.2.300.627
4l321VFTankyrase-22.4.2.300.626
4l341VGTankyrase-22.4.2.300.624
4l0t1V0Tankyrase-22.4.2.300.621
3kr8XAVTankyrase-22.4.2.300.619
4l0i1UWTankyrase-22.4.2.300.618
4l31F08Tankyrase-22.4.2.300.612
4kzl20DTankyrase-22.4.2.300.604
4kzuA73Tankyrase-22.4.2.300.601
4l2f1V3Tankyrase-22.4.2.300.600
4l10A63Tankyrase-22.4.2.300.597
4hlf15ZTankyrase-22.4.2.300.596
4bus32FTankyrase-22.4.2.300.595
4l2k1V8Tankyrase-22.4.2.300.595
4hkkAGITankyrase-22.4.2.300.592
4hlm16STankyrase-22.4.2.300.591
4hl515WTankyrase-22.4.2.300.590
3p0pNNFTankyrase-22.4.2.300.587
4hlh20DTankyrase-22.4.2.300.586
4bueJQFTankyrase-22.4.2.300.581
4hknLU2Tankyrase-22.4.2.300.581
4j21AJ6Tankyrase-22.4.2.300.580
4iueAJ4Tankyrase-22.4.2.300.577
4bud29FTankyrase-22.4.2.300.572
4hmhF94Tankyrase-22.4.2.300.571
4j22AJ7Tankyrase-22.4.2.300.571
4l2g1V4Tankyrase-22.4.2.300.569
4bs4A64Tankyrase-22.4.2.300.566
4buwF33Tankyrase-22.4.2.300.565
4l0v1V1Tankyrase-22.4.2.300.558
4krs1SXTankyrase-12.4.2.300.549
4j3mAJ8Tankyrase-22.4.2.300.537
4bj9UHBTankyrase-22.4.2.300.536
4pnrG18Tankyrase-22.4.2.300.527
4j3lAJ5Tankyrase-22.4.2.300.523
4l091URTankyrase-22.4.2.300.495
4tjy3GNTankyrase-22.4.2.300.487
4pnmNU1Tankyrase-22.4.2.300.480
4avuLDRTankyrase-22.4.2.300.474
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.470
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.467
4msk2C8Tankyrase-12.4.2.300.463
4o9cCOAAcetyl-CoA acetyltransferase2.3.1.90.462
4bjbP34Tankyrase-22.4.2.300.461
4i9i1DYTankyrase-12.4.2.300.461
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.460
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.459
4li81XQTankyrase-12.4.2.300.459
3zhtTD9Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.457
1xf0ASDAldo-keto reductase family 1 member C3/0.455
3vg9ZMAAdenosine receptor A2a/0.452
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.451
4li61XOTankyrase-12.4.2.300.451
2gesCOKPantothenate kinase2.7.1.330.450
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.450
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.450
1amoFMNNADPH--cytochrome P450 reductase/0.449
3fpkFADFerredoxin-NADP reductase/0.449
3zhsTD6Multifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.449
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.449
3iaaTYDCalG2/0.448
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.447
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.447
2bfaCB3Pteridine reductase 11.5.1.330.447
2zb8IMNProstaglandin reductase 21.3.1.480.447
3ch6311Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
1wl4COAAcetyl-CoA acetyltransferase, cytosolic2.3.1.90.446
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.446
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.445
1x8lOXRRetinol dehydratase/0.445
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.445
1mp0NADAlcohol dehydrogenase class-31.1.1.10.444
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.444
4m9aFDAAcyl-CoA dehydrogenase/0.444
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
5jqhCAUBeta-2 adrenergic receptor/0.443
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.442
3q9bB3NAcetylpolyamine amidohydrolase/0.442
4bfxZVXPantothenate kinase2.7.1.330.442
2aot2PMHistamine N-methyltransferase2.1.1.80.441
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.441
1b87ACOAac(6')-Ii protein/0.440
1fmlRTLRetinol dehydratase/0.440
2bf7HBIPteridine reductase 11.5.1.330.440
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.440
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.440