Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hgt15GCasein kinase I isoform delta2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hgt15GCasein kinase I isoform delta2.7.11.11.000
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.524
4hgs15GCasein kinase I isoform gamma-32.7.11.10.521
2izsBRQCasein kinase I isoform gamma-32.7.11.10.511
2izrBRKCasein kinase I isoform gamma-32.7.11.10.508
2izt23DCasein kinase I isoform gamma-32.7.11.10.506
2c475IDCasein kinase I isoform gamma-2/0.503
4g170VNCasein kinase I isoform gamma-32.7.11.10.500
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.489
3gubGUBDeath-associated protein kinase 12.7.11.10.484
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.483
4kba1QMCasein kinase I isoform delta2.7.11.10.483
1fvv107Cyclin-dependent kinase 22.7.11.220.481
2iw84SPCyclin-dependent kinase 22.7.11.220.480
4g160VMCasein kinase I isoform gamma-32.7.11.10.478
4kbk1QGCasein kinase I isoform delta2.7.11.10.478
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.476
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.476
3ormAGSSerine/threonine protein kinase/0.476
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.475
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.475
2iw94SPCyclin-dependent kinase 22.7.11.220.474
2izuP01Casein kinase I isoform gamma-32.7.11.10.472
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.472
3ggfGVDSerine/threonine-protein kinase 26/0.472
2x1nX1NCyclin-dependent kinase 22.7.11.220.471
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.471
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.471
4c4h7RODual specificity protein kinase TTK2.7.12.10.469
3qqkX02Cyclin-dependent kinase 22.7.11.220.467
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.467
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.467
1pkdUCNCyclin-dependent kinase 22.7.11.220.466
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.466
1xjdSTUProtein kinase C theta type2.7.11.130.465
2b52D42Cyclin-dependent kinase 22.7.11.220.465
3lltANPProtein serine/threonine kinase-1/0.465
1oi9N20Cyclin-dependent kinase 22.7.11.220.464
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.464
3rk708ZCyclin-dependent kinase 22.7.11.220.464
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.464
1h1r6CPCyclin-dependent kinase 22.7.11.220.463
3bqr4RBDeath-associated protein kinase 3/0.463
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.463
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.463
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.463
4kb81QNCasein kinase I isoform delta2.7.11.10.463
1oiyN41Cyclin-dependent kinase 22.7.11.220.462
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.462
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.462
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
3umw596Serine/threonine-protein kinase pim-12.7.11.10.461
4dgnLU2Casein kinase II subunit alpha2.7.11.10.461
4fx360KCyclin-dependent kinase 22.7.11.220.461
1h1s4SPCyclin-dependent kinase 22.7.11.220.460
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.460
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.460
4i22IREEpidermal growth factor receptor2.7.10.10.460
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
2j0j4STFocal adhesion kinase 12.7.10.20.459
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.459
1ke6LS2Cyclin-dependent kinase 22.7.11.220.457
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.457
4jboWPHAurora kinase A2.7.11.10.457
4bcnT9NCyclin-dependent kinase 22.7.11.220.456
2j0lANPFocal adhesion kinase 12.7.10.20.455
2j0m4STFocal adhesion kinase 12.7.10.20.455
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.455
3ral04ZCyclin-dependent kinase 22.7.11.220.455
3zep1NXTyrosine-protein kinase JAK32.7.10.20.455
2ca0PXICytochrome P450 monooxygenase PikC/0.454
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.454
3sqq99ZCyclin-dependent kinase 22.7.11.220.454
4aotGW8Serine/threonine-protein kinase 102.7.11.10.454
4c4jX21Dual specificity protein kinase TTK2.7.12.10.454
4ez50RSCyclin-dependent kinase 62.7.11.220.454
4j99ACPFibroblast growth factor receptor 2/0.454
1m2rMNYCasein kinase II subunit alpha2.7.11.10.453
1oguST8Cyclin-dependent kinase 22.7.11.220.453
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.453
2uzlC94Cyclin-dependent kinase 22.7.11.220.453
2w05FRTCyclin-dependent kinase 22.7.11.220.453
3at4CCKCasein kinase II subunit alpha2.7.11.10.453
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.452
3kvxFMYMitogen-activated protein kinase 102.7.11.240.452
3zh8C58Protein kinase C iota type2.7.11.130.452
4grb0XGCasein kinase II subunit alpha2.7.11.10.452
4iaq2GM5-hydroxytryptamine receptor 1B/0.452
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
4riyADPEpidermal growth factor receptor2.7.10.10.452
1gih1PUCyclin-dependent kinase 22.7.11.220.451
1pxmCK5Cyclin-dependent kinase 22.7.11.220.451
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.451
2znnS44Peroxisome proliferator-activated receptor alpha/0.451
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.451
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.451
3a7hATPSerine/threonine-protein kinase 242.7.11.10.450
3lfqA28Cyclin-dependent kinase 22.7.11.220.450
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.450
4bcqTJFCyclin-dependent kinase 22.7.11.220.450
4eon1ROCyclin-dependent kinase 22.7.11.220.450
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.450
4yuqKS1Calmodulin-like domain protein kinase/0.450
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.449
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.449
3r9hZ67Cyclin-dependent kinase 22.7.11.220.449
3t8oATPRhodopsin kinase/0.449
3u4uLNHCasein kinase II subunit alpha2.7.11.10.449
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.449
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.449
1ckpPVBCyclin-dependent kinase 22.7.11.220.448
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.448
2vv9IM9Cyclin-dependent kinase 22.7.11.220.448
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.448
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.448
3uvqFS8Mitogen-activated protein kinase 14/0.448
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.448
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.448
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.448
4fv9E71Mitogen-activated protein kinase 12.7.11.240.448
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.448
1k6pXN3Gag-Pol polyprotein3.4.23.160.447
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.447
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.447
2in6839Wee1-like protein kinase2.7.10.20.447
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.447
2xikJ60Serine/threonine-protein kinase 252.7.11.10.447
3s0o50ZCyclin-dependent kinase 22.7.11.220.447
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.447
4qmzB49Serine/threonine-protein kinase 242.7.11.10.447
4r21STRCytochrome P450 family 17 polypeptide 2/0.447
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.446
3ezrEZRCyclin-dependent kinase 22.7.11.220.446
3lfnA27Cyclin-dependent kinase 22.7.11.220.446
3nynSGVG protein-coupled receptor kinase 62.7.11.160.446
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
3qzgX67Cyclin-dependent kinase 22.7.11.220.446
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.446
4fkpLS5Cyclin-dependent kinase 22.7.11.220.446
4j95ACPFibroblast growth factor receptor 2/0.446
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.446
4mcb21WtRNA (guanine-N(1)-)-methyltransferase2.1.1.2280.446
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
1fvt106Cyclin-dependent kinase 22.7.11.220.445
2btsU32Cyclin-dependent kinase 22.7.11.220.445
2csnCKICasein kinase I homolog 12.7.11.10.445
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.445
3at3ATKCasein kinase II subunit alpha2.7.11.10.445
3r1sX73Cyclin-dependent kinase 22.7.11.220.445
3s1h56ZCyclin-dependent kinase 22.7.11.220.445
3uyt0CKCasein kinase I isoform delta2.7.11.10.445
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.445
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.445
4gmy0X5Tyrosine-protein kinase JAK2/0.445
1gij2PUCyclin-dependent kinase 22.7.11.220.444
1s9jBBMDual specificity mitogen-activated protein kinase kinase 12.7.12.20.444
1u54ACPActivated CDC42 kinase 1/0.444
2chlDKICasein kinase I isoform gamma-32.7.11.10.444
2duv371Cyclin-dependent kinase 22.7.11.220.444
2w17I19Cyclin-dependent kinase 22.7.11.220.444
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.444
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.444
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.444
3qtuX44Cyclin-dependent kinase 22.7.11.220.444
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.444
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.444
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.444
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.444
1aq1STUCyclin-dependent kinase 22.7.11.220.443
1v1k3FPCyclin-dependent kinase 22.7.11.220.443
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.443
2eufLQQCyclin-dependent kinase 62.7.11.220.443
2pvnP63Casein kinase II subunit alpha2.7.11.10.443
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.443
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.443
3be9P04Casein kinase II subunit alpha2.7.11.10.443
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.443
3rak03ZCyclin-dependent kinase 22.7.11.220.443
3rpv26ZCyclin-dependent kinase 22.7.11.220.443
4ib4ERM5-hydroxytryptamine receptor 2B/0.443
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.443
4xf7ACPCarbohydrate/pyrimidine kinase, PfkB family/0.443
4xhgADPUncharacterized protein/0.443
1g5sI17Cyclin-dependent kinase 22.7.11.220.442
1ke5LS1Cyclin-dependent kinase 22.7.11.220.442
1ke9LS5Cyclin-dependent kinase 22.7.11.220.442
2c6tDT5Cyclin-dependent kinase 22.7.11.220.442
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.442
3k5uPFQAurora kinase A2.7.11.10.442
3w33W19Epidermal growth factor receptor2.7.10.10.442
4b7sQLECytochrome P450 monooxygenase PikC/0.442
4bcpT3CCyclin-dependent kinase 22.7.11.220.442
4c4f7CEDual specificity protein kinase TTK2.7.12.10.442
4fp9SAM5-methylcytosine rRNA methyltransferase NSUN42.1.10.442
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.442
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.442
4hnf16WCasein kinase I isoform delta2.7.11.10.442
4iarERM5-hydroxytryptamine receptor 1B/0.442
1dm2HMDCyclin-dependent kinase 22.7.11.220.441
1oiuN76Cyclin-dependent kinase 22.7.11.220.441
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.441
2a5uQYTPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
2b55D31Cyclin-dependent kinase 22.7.11.220.441
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.441
3efwAK8Aurora kinase A2.7.11.10.441
3r9dX6BCyclin-dependent kinase 22.7.11.220.441
3rk507ZCyclin-dependent kinase 22.7.11.220.441
4b7dQLECytochrome P450 monooxygenase PikC/0.441
4bbe3O4Tyrosine-protein kinase JAK2/0.441
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.441
4fkw62KCyclin-dependent kinase 22.7.11.220.441
5cu6ATPCasein kinase II subunit alpha2.7.11.10.441
5cvfATPCasein kinase II subunit alpha2.7.11.10.441
1e8wQUEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2pvhP19Casein kinase II subunit alpha2.7.11.10.440
2xrwANPMitogen-activated protein kinase 82.7.11.240.440
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.440
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4eok4SPCyclin-dependent kinase 22.7.11.220.440
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.440
4iebANPCalmodulin-domain protein kinase 1/0.440
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.440
4jbpYPHAurora kinase A2.7.11.10.440
4jq8KJ8Epidermal growth factor receptor2.7.10.10.440