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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hge15VTyrosine-protein kinase JAK2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hge15VTyrosine-protein kinase JAK2/1.000
4aqc88ATyrosine-protein kinase JAK2/0.618
3lpbNVBTyrosine-protein kinase JAK2/0.586
4i5cC5ITyrosine-protein kinase JAK1/0.569
4e6d0NUTyrosine-protein kinase JAK2/0.568
3iok1P6Tyrosine-protein kinase JAK2/0.567
4hvi19STyrosine-protein kinase JAK32.7.10.20.557
3rvg17PTyrosine-protein kinase JAK2/0.555
4ji91M3Tyrosine-protein kinase JAK2/0.552
2b7aIZATyrosine-protein kinase JAK2/0.545
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.544
4ivb1J5Tyrosine-protein kinase JAK1/0.542
2pvmP29Casein kinase II subunit alpha2.7.11.10.540
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.540
2j0m4STFocal adhesion kinase 12.7.10.20.534
4c61LMMTyrosine-protein kinase JAK2/0.534
4e6q0NVTyrosine-protein kinase JAK2/0.532
5e92ANPTGF-beta receptor type-22.7.11.300.529
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.528
4wsqKSAAP2-associated protein kinase 12.7.11.10.528
4f081RSTyrosine-protein kinase JAK2/0.527
3be9P04Casein kinase II subunit alpha2.7.11.10.524
3rak03ZCyclin-dependent kinase 22.7.11.220.524
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.523
4fv6E57Mitogen-activated protein kinase 12.7.11.240.521
2pvnP63Casein kinase II subunit alpha2.7.11.10.518
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.514
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.514
3s1h56ZCyclin-dependent kinase 22.7.11.220.514
5e8ySTUTGF-beta receptor type-22.7.11.300.514
1m2pHNACasein kinase II subunit alpha2.7.11.10.512
2pvhP19Casein kinase II subunit alpha2.7.11.10.512
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.512
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.511
4anmWULCasein kinase II subunit alpha2.7.11.10.511
4e4n0NLTyrosine-protein kinase JAK1/0.511
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.510
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.510
3qtuX44Cyclin-dependent kinase 22.7.11.220.509
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.508
4qnyANPMitogen activated protein kinase, putative/0.508
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.507
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.507
4ehzJAKTyrosine-protein kinase JAK1/0.507
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.506
1xjdSTUProtein kinase C theta type2.7.11.130.505
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.505
3i60E86Mitogen-activated protein kinase 12.7.11.240.505
4gmy0X5Tyrosine-protein kinase JAK2/0.505
4jia1K3Tyrosine-protein kinase JAK2/0.505
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.505
4o0wADNAurora kinase A2.7.11.10.505
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.504
3gubGUBDeath-associated protein kinase 12.7.11.10.504
3orkAGSSerine/threonine protein kinase/0.504
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.504
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.504
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.502
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.502
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.502
1yvj4STTyrosine-protein kinase JAK32.7.10.20.501
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.501
2pvlP55Casein kinase II subunit alpha2.7.11.10.501
4dymIYZActivin receptor type-12.7.11.300.501
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.501
2vu3LZECyclin-dependent kinase 22.7.11.220.500
4btjADPTau-tubulin kinase 12.7.11.10.500
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.500
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.500
1u54ACPActivated CDC42 kinase 1/0.499
3t8oATPRhodopsin kinase/0.499
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.499
4fmqANPMitogen-activated protein kinase 12.7.11.240.499
4iva1J5Tyrosine-protein kinase JAK2/0.499
5e8wSTUTGF-beta receptor type-12.7.11.300.499
4bbfO19Tyrosine-protein kinase JAK2/0.498
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.498
4h3qANPMitogen-activated protein kinase 12.7.11.240.497
2vv9IM9Cyclin-dependent kinase 22.7.11.220.495
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.495
3at4CCKCasein kinase II subunit alpha2.7.11.10.495
3gxlQIGTGF-beta receptor type-12.7.11.300.495
4btjATPTau-tubulin kinase 12.7.11.10.495
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.494
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.494
4i22IREEpidermal growth factor receptor2.7.10.10.494
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.494
2xa4AZ5Tyrosine-protein kinase JAK2/0.493
3eljGS7Mitogen-activated protein kinase 82.7.11.240.493
3oroAGSSerine/threonine protein kinase/0.493
4dgnLU2Casein kinase II subunit alpha2.7.11.10.493
5dt3ATPAurora kinase A2.7.11.10.493
1g5sI17Cyclin-dependent kinase 22.7.11.220.492
5av2KMPDeath-associated protein kinase 12.7.11.10.492
5dnrATPAurora kinase A2.7.11.10.492
1om1IQACasein kinase II subunit alpha2.7.11.10.491
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.491
1w8cN69Cyclin-dependent kinase 22.7.11.220.491
2x1nX1NCyclin-dependent kinase 22.7.11.220.491
4deeADPAurora kinase A2.7.11.10.491
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.491
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.491
2xneASHAurora kinase A2.7.11.10.490
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.490
4bgg844Activin receptor type-12.7.11.300.489
4btmF8ETau-tubulin kinase 12.7.11.10.489
1m2rMNYCasein kinase II subunit alpha2.7.11.10.488
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
2ijmATPFocal adhesion kinase 12.7.10.20.488
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.488
4bbe3O4Tyrosine-protein kinase JAK2/0.487
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.487
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.487
4lrjANPUncharacterized protein/0.487
1eh4IC1Casein kinase I homolog 12.7.11.10.486
3eyhIZATyrosine-protein kinase JAK1/0.486
3ncz3NCRho-associated protein kinase 12.7.11.10.486
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.486
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.486
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.486
4ewhT77Activated CDC42 kinase 1/0.486
5cnoANPEpidermal growth factor receptor2.7.10.10.486
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.485
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.484
4iwd1JCHepatocyte growth factor receptor2.7.10.10.484
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.484
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.483
2w05FRTCyclin-dependent kinase 22.7.11.220.483
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.483
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.483
3zewSTUEphrin type-B receptor 42.7.10.10.483
4k33ACPFibroblast growth factor receptor 32.7.10.10.483
4qmpDKISerine/threonine-protein kinase 242.7.11.10.483
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.483
5cvfATPCasein kinase II subunit alpha2.7.11.10.483
2hckQUETyrosine-protein kinase HCK2.7.10.20.482
3ggfGVDSerine/threonine-protein kinase 26/0.482
3r8lZ30Cyclin-dependent kinase 22.7.11.220.482
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.482
4ivc1J6Tyrosine-protein kinase JAK1/0.482
5cnnANPEpidermal growth factor receptor2.7.10.10.482
1dayGNPCasein kinase II subunit alpha2.7.11.10.481
3nynSGVG protein-coupled receptor kinase 62.7.11.160.481
4nifANPMitogen-activated protein kinase 12.7.11.240.481
1h1s4SPCyclin-dependent kinase 22.7.11.220.480
3gu7ADPDeath-associated protein kinase 12.7.11.10.480
3ormAGSSerine/threonine protein kinase/0.480
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.480
4eooATPCyclin-dependent kinase 22.7.11.220.480
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.480
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.480
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.480
1u4dDBQActivated CDC42 kinase 1/0.479
3lxkMI1Tyrosine-protein kinase JAK32.7.10.20.479
3rk708ZCyclin-dependent kinase 22.7.11.220.479
3sheI85MAP kinase-activated protein kinase 32.7.11.10.479
1e9hINRCyclin-dependent kinase 22.7.11.220.478
1h1r6CPCyclin-dependent kinase 22.7.11.220.478
1oitHDTCyclin-dependent kinase 22.7.11.220.478
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.478
1ykr628Cyclin-dependent kinase 22.7.11.220.478
2ijmADPFocal adhesion kinase 12.7.10.20.478
3sw719KCyclin-dependent kinase 22.7.11.220.478
3zep1NXTyrosine-protein kinase JAK32.7.10.20.478
4e4l0NHTyrosine-protein kinase JAK1/0.478
4e5w0NTTyrosine-protein kinase JAK1/0.478
4lfiGNPCasein kinase II subunit alpha2.7.11.10.478
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.478
5dmzADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.478
1h0w207Cyclin-dependent kinase 22.7.11.220.477
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.477
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.477
2h96893Mitogen-activated protein kinase 82.7.11.240.477
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.477
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.477
4fko20KCyclin-dependent kinase 22.7.11.220.477
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.477
1bygSTUTyrosine-protein kinase CSK/0.476
2b52D42Cyclin-dependent kinase 22.7.11.220.476
2c6lDT4Cyclin-dependent kinase 22.7.11.220.476
3hmm855TGF-beta receptor type-12.7.11.300.476
3sw418KCyclin-dependent kinase 22.7.11.220.476
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.476
4k771Q4Tyrosine-protein kinase JAK1/0.476
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.476
5auvAGIDeath-associated protein kinase 12.7.11.10.476
5dn3ATPAurora kinase A2.7.11.10.476
1y91CT9Cyclin-dependent kinase 22.7.11.220.475
2cciATPCyclin-dependent kinase 22.7.11.220.475
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.475
3u4uLNHCasein kinase II subunit alpha2.7.11.10.475
3zh8C58Protein kinase C iota type2.7.11.130.475
3zmmF9JTyrosine-protein kinase JAK2/0.475
4bgh3I6Cyclin-dependent kinase 22.7.11.220.475
4ez50RSCyclin-dependent kinase 62.7.11.220.475
4fkv61KCyclin-dependent kinase 22.7.11.220.475
4jqeANPCasein kinase II subunit alpha2.7.11.10.475
5e8xSTUTGF-beta receptor type-12.7.11.300.475
1ec3MS3Gag-Pol polyprotein3.4.23.160.474
2bpv1INGag-Pol polyprotein3.4.23.160.474
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
3rmf20ZCyclin-dependent kinase 22.7.11.220.474
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.474
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.474
4ux9ANPMitogen-activated protein kinase 82.7.11.240.474
1dawANPCasein kinase II subunit alpha2.7.11.10.473
1pkgADPMast/stem cell growth factor receptor Kit2.7.10.10.473
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.473
3mtfA3FActivin receptor type-12.7.11.300.473
3r9dX6BCyclin-dependent kinase 22.7.11.220.473
4ysjADPCalmodulin-like domain protein kinase/0.473
5dosATPAurora kinase A2.7.11.10.473
1jklANPDeath-associated protein kinase 12.7.11.10.472
3nieANPMitogen-activated protein kinase/0.472
3ortAGSSerine/threonine protein kinase/0.472
4aguD15Cyclin-dependent kinase-like 1/0.472
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.472
4eok4SPCyclin-dependent kinase 22.7.11.220.472
4fk60UJTyrosine-protein kinase JAK1/0.472
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.472
1fvv107Cyclin-dependent kinase 22.7.11.220.471
2uzbC75Cyclin-dependent kinase 22.7.11.220.471
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.471
4acm7YGCyclin-dependent kinase 22.7.11.220.471
4ivd15TTyrosine-protein kinase JAK1/0.471
4jr7GNPCasein kinase II subunit alpha2.7.11.10.471
4qmlANPSerine/threonine-protein kinase 242.7.11.10.471
4y93746Tyrosine-protein kinase/0.471
5auxKMPDeath-associated protein kinase 12.7.11.10.471
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.470
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.470
2j0lANPFocal adhesion kinase 12.7.10.20.470
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.470
3pe2E1BCasein kinase II subunit alpha2.7.11.10.470
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.470
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.470
5dr6SKEAurora kinase A2.7.11.10.470
1pkdUCNCyclin-dependent kinase 22.7.11.220.469
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
2v7a627Tyrosine-protein kinase ABL12.7.10.20.469
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.469
4e4m0NHTyrosine-protein kinase JAK2/0.469
4f9c0SXCell division cycle 7-related protein kinase2.7.11.10.469
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.469
4fv9E71Mitogen-activated protein kinase 12.7.11.240.469
5av3KMPDeath-associated protein kinase 12.7.11.10.469
1di8DTQCyclin-dependent kinase 22.7.11.220.468
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.468
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.468
2w1fL0FAurora kinase A2.7.11.10.468
2yaaATPDeath-associated protein kinase 2/0.468
3lltANPProtein serine/threonine kinase-1/0.468
3orpAGSSerine/threonine protein kinase/0.468
4c62XWWTyrosine-protein kinase JAK2/0.468
4ei40Q2Tyrosine-protein kinase JAK1/0.468
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.468
1oguST8Cyclin-dependent kinase 22.7.11.220.467
1oirHDYCyclin-dependent kinase 22.7.11.220.467
1oiuN76Cyclin-dependent kinase 22.7.11.220.467
2c6iDT1Cyclin-dependent kinase 22.7.11.220.467
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.467
3at3ATKCasein kinase II subunit alpha2.7.11.10.467
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.467
4j99ACPFibroblast growth factor receptor 2/0.467
4jbqVX6Aurora kinase A2.7.11.10.467
2eufLQQCyclin-dependent kinase 62.7.11.220.466
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2fvdLIACyclin-dependent kinase 22.7.11.220.466
2iw94SPCyclin-dependent kinase 22.7.11.220.466
2wotZZGTGF-beta receptor type-12.7.11.300.466
3uli1N3Cyclin-dependent kinase 22.7.11.220.466
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.466
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.466
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.466
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.466
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.465
1oiyN41Cyclin-dependent kinase 22.7.11.220.465
2bpw1INGag-Pol polyprotein3.4.23.160.465
2np8CC3Aurora kinase A2.7.11.10.465
2vtqLZACyclin-dependent kinase 22.7.11.220.465
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.465
3oriAGSSerine/threonine protein kinase/0.465
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.465
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.465
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.464
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.464
3q9xEMOCasein kinase II subunit alpha2.7.11.10.464
3uyt0CKCasein kinase I isoform delta2.7.11.10.464
3w8qAGSDual specificity mitogen-activated protein kinase kinase 12.7.12.20.464
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.464
4erwSTUCyclin-dependent kinase 22.7.11.220.464
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.464
1ebwBEIGag-Pol polyprotein3.4.23.160.463
1pxpCK8Cyclin-dependent kinase 22.7.11.220.463
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.463
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.463
3ddpRC8Cyclin-dependent kinase 22.7.11.220.463
3kvxFMYMitogen-activated protein kinase 102.7.11.240.463
3qx2X63Cyclin-dependent kinase 22.7.11.220.463
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.463
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.463
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.462
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.462
2dwbANPAurora kinase A2.7.11.10.462
2r64740Cyclin-dependent kinase 22.7.11.220.462
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.462
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.462
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.462
3rpv26ZCyclin-dependent kinase 22.7.11.220.462
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.462
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.462
1aq1STUCyclin-dependent kinase 22.7.11.220.461
1e1xNW1Cyclin-dependent kinase 22.7.11.220.461
1pxmCK5Cyclin-dependent kinase 22.7.11.220.461
1py5PY1TGF-beta receptor type-12.7.11.300.461
1qmzATPCyclin-dependent kinase 22.7.11.220.461
2in6839Wee1-like protein kinase2.7.10.20.461
2uxzHI1Gag-Pol polyprotein3.4.23.160.461
2xb7GUIALK tyrosine kinase receptor2.7.10.10.461
2yn8STUEphrin type-B receptor 42.7.10.10.461
3pxkPXKFocal adhesion kinase 12.7.10.20.461
3r83Z14Cyclin-dependent kinase 22.7.11.220.461
4eor4SPCyclin-dependent kinase 22.7.11.220.461
4grb0XGCasein kinase II subunit alpha2.7.11.10.461
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.461
4q5hANPProtein kinase OspG2.70.461
2bkzSBCCyclin-dependent kinase 22.7.11.220.460
2c5yMTWCyclin-dependent kinase 22.7.11.220.460
2iw84SPCyclin-dependent kinase 22.7.11.220.460
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.460
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.460
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.460
3vf80JETyrosine-protein kinase SYK2.7.10.20.460
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.460
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.460
4ii5ADPCyclin-dependent kinase 22.7.11.220.460
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.460
5drdATPAurora kinase A2.7.11.10.460
2c5nCK8Cyclin-dependent kinase 22.7.11.220.459
2cchATPCyclin-dependent kinase 22.7.11.220.459
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.459
2w4jADPDeath-associated protein kinase 12.7.11.10.459
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.459
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.459
4gii0X6Non-receptor tyrosine-protein kinase TYK22.7.10.20.459
4hvh19RTyrosine-protein kinase JAK32.7.10.20.459
4o0uADNAurora kinase A2.7.11.10.459
2a0cCK9Cyclin-dependent kinase 22.7.11.220.458
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.458
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.458
2ckeIQUDeath-associated protein kinase 2/0.458
2r3iSCFCyclin-dependent kinase 22.7.11.220.458
2w17I19Cyclin-dependent kinase 22.7.11.220.458
3cgfJNFMitogen-activated protein kinase 102.7.11.240.458
3ddqRRCCyclin-dependent kinase 22.7.11.220.458
3dfcANPDeath-associated protein kinase 12.7.11.10.458
3rk507ZCyclin-dependent kinase 22.7.11.220.458
3rkb12ZCyclin-dependent kinase 22.7.11.220.458
4dgmAGICasein kinase II subunit alpha2.7.11.10.458
4hvg19QTyrosine-protein kinase JAK32.7.10.20.458
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.458
4l9i8PRRhodopsin kinase/0.458
4otiMI1Serine/threonine-protein kinase N1/0.458
5auwQUEDeath-associated protein kinase 12.7.11.10.458
1p2a5BNCyclin-dependent kinase 22.7.11.220.457
2c6o4SPCyclin-dependent kinase 22.7.11.220.457
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2p33J07Mitogen-activated protein kinase 102.7.11.240.457
2rioADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.457
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.457
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.457
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.457
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.457
3qzgX67Cyclin-dependent kinase 22.7.11.220.457
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.457
4e1z0MXNon-receptor tyrosine-protein kinase TYK22.7.10.20.457
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.457
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.457
4gfo0X2Non-receptor tyrosine-protein kinase TYK22.7.10.20.457
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.457
4xlvACPInsulin receptor2.7.10.10.457
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.456
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.456
1pmn984Mitogen-activated protein kinase 102.7.11.240.456
1pxlCK4Cyclin-dependent kinase 22.7.11.220.456
1yt9OISGag-Pol polyprotein/0.456
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.456
2izsBRQCasein kinase I isoform gamma-32.7.11.10.456
2j9mPY8Cyclin-dependent kinase 22.7.11.220.456
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.456
2w1gL0GAurora kinase A2.7.11.10.456
3a62STURibosomal protein S6 kinase beta-12.7.11.10.456
3eb0DRKUncharacterized protein/0.456
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.456
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.456
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.456
1ke7LS3Cyclin-dependent kinase 22.7.11.220.455
2hog710Serine/threonine-protein kinase Chk12.7.11.10.455
2ojj82AMitogen-activated protein kinase 12.7.11.240.455
2xmyCDKCyclin-dependent kinase 22.7.11.220.455
3fz1B98Cyclin-dependent kinase 22.7.11.220.455
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.455
3r73X87Cyclin-dependent kinase 22.7.11.220.455
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.455
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.455
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.455
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.455
4fvqATPTyrosine-protein kinase JAK2/0.455
1gii1PUCyclin-dependent kinase 22.7.11.220.454
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.454
4fod0UVALK tyrosine kinase receptor2.7.10.10.454
4ic7ANPMitogen-activated protein kinase 72.7.11.240.454
4xumIMNPeroxisome proliferator-activated receptor gamma/0.454
5eg3ACPFibroblast growth factor receptor 2/0.454
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.453
1oi9N20Cyclin-dependent kinase 22.7.11.220.453
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.453
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3bu5ATPInsulin receptor2.7.10.10.453
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.453
3qc9ADPRhodopsin kinase/0.453
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4bcoT6QCyclin-dependent kinase 22.7.11.220.453
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.453
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.453
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.453
1ebyBEBGag-Pol polyprotein3.4.23.160.452
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.452
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.452
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.452
3qtzX42Cyclin-dependent kinase 22.7.11.220.452
3zdu38RCyclin-dependent kinase-like 32.7.11.220.452
4bcmT7ZCyclin-dependent kinase 22.7.11.220.452
4c57FEFCyclin-G-associated kinase2.7.11.10.452
5cshATPCasein kinase II subunit alpha2.7.11.10.452
1ke6LS2Cyclin-dependent kinase 22.7.11.220.451
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.451
2bhhRYUCyclin-dependent kinase 22.7.11.220.451
2bpxMK1Gag-Pol polyprotein3.4.23.160.451
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.451
3c4wATPRhodopsin kinase/0.451
3c4zADPRhodopsin kinase/0.451
4im2BX7Serine/threonine-protein kinase TBK12.7.11.10.451
4jajXU1Aurora kinase A2.7.11.10.451
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.450
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.450
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.450
2xrwANPMitogen-activated protein kinase 82.7.11.240.450
2xs0ANPMitogen-activated protein kinase 82.7.11.240.450
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.450
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.450
3tdvGDPGentamicin resistance protein/0.450
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.450
3ttjJBIMitogen-activated protein kinase 102.7.11.240.450
3w16P9JAurora kinase A2.7.11.10.450
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.450
4gub0Y4Casein kinase II subunit alpha2.7.11.10.450
4j95ACPFibroblast growth factor receptor 2/0.450
4jrnANPRhoptry kinase family protein/0.450
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.450
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.450
1pxoCK7Cyclin-dependent kinase 22.7.11.220.449
1pyePM1Cyclin-dependent kinase 22.7.11.220.449
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.449
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.449
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.449
3bheBZNGag-Pol polyprotein3.4.23.160.449
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.449
4jbpYPHAurora kinase A2.7.11.10.449
4o1pANPRibonuclease L/0.449
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.448
1wvySTUDeath-associated protein kinase 12.7.11.10.448
2excJNKMitogen-activated protein kinase 102.7.11.240.448
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
2jdvL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.448
2q5g1FAPeroxisome proliferator-activated receptor delta/0.448
2w1hL0FCyclin-dependent kinase 22.7.11.220.448
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.448
3bc3OPTCathepsin L13.4.22.150.448
3le62BZCyclin-dependent kinase 22.7.11.220.448
3qu0X40Cyclin-dependent kinase 22.7.11.220.448
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.448
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.448
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.448
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.448
4ckjADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
4ek816KCyclin-dependent kinase 22.7.11.220.448
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.448
1bdrIM1Gag-Pol polyprotein3.4.23.160.447
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.447
2cen4AHProtease/0.447
2csnCKICasein kinase I homolog 12.7.11.10.447
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.447
2qi5MZ7Gag-Pol polyprotein/0.447
2r3jSCJCyclin-dependent kinase 22.7.11.220.447
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2x9dITCTetracycline repressor protein class D/0.447
2xikJ60Serine/threonine-protein kinase 252.7.11.10.447
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3nux3NVCyclin-dependent kinase 62.7.11.220.447
3qqkX02Cyclin-dependent kinase 22.7.11.220.447
3qzhX69Cyclin-dependent kinase 22.7.11.220.447
3r71X86Cyclin-dependent kinase 22.7.11.220.447
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.447
4o4fATPKinase/0.447
1ec1BEEGag-Pol polyprotein3.4.23.160.446
1pjkANPCasein kinase II subunit alpha2.7.11.10.446
1w0xOLOCyclin-dependent kinase 22.7.11.220.446
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2f2uM77Rho-associated protein kinase 22.7.11.10.446
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.446
2q9fC3SCholesterol 24-hydroxylase/0.446
3k5uPFQAurora kinase A2.7.11.10.446
3lfqA28Cyclin-dependent kinase 22.7.11.220.446
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.446
3r8vZ62Cyclin-dependent kinase 22.7.11.220.446
3rk909ZCyclin-dependent kinase 22.7.11.220.446
3w551FMMitogen-activated protein kinase 12.7.11.240.446
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.446
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
4eon1ROCyclin-dependent kinase 22.7.11.220.446
2pmoHMDProtein kinase 7/0.445
2upjU02Gag-Pol polyprotein3.4.23.160.445
2x6dX6DAurora kinase A2.7.11.10.445
3efwAK8Aurora kinase A2.7.11.10.445
3h0aD30Peroxisome proliferator-activated receptor gamma/0.445
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.445
3oom507Activin receptor type-12.7.11.300.445
3ral04ZCyclin-dependent kinase 22.7.11.220.445
3rpo24ZCyclin-dependent kinase 22.7.11.220.445
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4hgs15GCasein kinase I isoform gamma-32.7.11.10.445
4ix6ADPUncharacterized protein/0.445
4k6z1Q3Tyrosine-protein kinase JAK1/0.445
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.445
4o0sADNAurora kinase A2.7.11.10.445
1b38ATPCyclin-dependent kinase 22.7.11.220.444
2fxeDR7Gag-Pol polyprotein3.4.23.160.444
2i40BLZCyclin-dependent kinase 22.7.11.220.444
2npaMMBPeroxisome proliferator-activated receptor alpha/0.444
2vttLZDCyclin-dependent kinase 22.7.11.220.444
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.444
2zdt46CMitogen-activated protein kinase 102.7.11.240.444
3d7tSTUTyrosine-protein kinase CSK/0.444
3dogNNNCyclin-dependent kinase 22.7.11.220.444
3gu6ADPDeath-associated protein kinase 12.7.11.10.444
3kfs3TLGag-Pol polyprotein/0.444
3tnwF18Cyclin-dependent kinase 22.7.11.220.444
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.444
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.444
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.444
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.444
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.444
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.444
4riyADPEpidermal growth factor receptor2.7.10.10.444
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
5cvhADPCasein kinase II subunit alpha2.7.11.10.444
1gih1PUCyclin-dependent kinase 22.7.11.220.443
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2x2kX2KProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
2y9qANPMitogen-activated protein kinase 12.7.11.240.443
2zdu446Mitogen-activated protein kinase 102.7.11.240.443
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.443
3lq5SLQCyclin-dependent kinase 92.7.11.220.443
3sz0FADSulfide-quinone reductase/0.443
3w2sW2REpidermal growth factor receptor2.7.10.10.443
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4bcnT9NCyclin-dependent kinase 22.7.11.220.443
4bcpT3CCyclin-dependent kinase 22.7.11.220.443
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.443
5dpvSKEAurora kinase A2.7.11.10.443
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1w5xBE5Gag-Pol polyprotein3.4.23.160.442
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.442
2c6tDT5Cyclin-dependent kinase 22.7.11.220.442
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.442
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.442
2zjwREFCasein kinase II subunit alpha2.7.11.10.442
3jvy017Gag-Pol polyprotein3.4.23.160.442
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.442
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.442
3q9wEMOCasein kinase II subunit alpha2.7.11.10.442
3ttiKBIMitogen-activated protein kinase 102.7.11.240.442
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.442
4aotGW8Serine/threonine-protein kinase 102.7.11.10.442
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.442
1k6pXN3Gag-Pol polyprotein3.4.23.160.441
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.441
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.441
1v1k3FPCyclin-dependent kinase 22.7.11.220.441
2bfyH1NAurora kinase B-A2.7.11.10.441
2bqvA1AProtease/0.441
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.441
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.441
3c4xATPRhodopsin kinase/0.441
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.441
3itjFADThioredoxin reductase 11.8.1.90.441
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.441
3qn8NI7Gag-Pol polyprotein3.4.23.160.441
3qtxX43Cyclin-dependent kinase 22.7.11.220.441
3s2pPMUCyclin-dependent kinase 22.7.11.220.441
4enhFVXCholesterol 24-hydroxylase/0.441
4fklCK2Cyclin-dependent kinase 22.7.11.220.441
4foc0UUALK tyrosine kinase receptor2.7.10.10.441
4kd11QKCyclin-dependent kinase 22.7.11.220.441
5dt0SKEAurora kinase A2.7.11.10.441
1hckATPCyclin-dependent kinase 22.7.11.220.440
1i44ACPInsulin receptor2.7.10.10.440
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
2aazCB3Thymidylate synthase2.1.1.450.440
2bpy3INGag-Pol polyprotein3.4.23.160.440
3bqr4RBDeath-associated protein kinase 3/0.440
3cgoJNOMitogen-activated protein kinase 102.7.11.240.440
3dv3MEKDual specificity mitogen-activated protein kinase kinase 12.7.12.20.440
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.440
3nwxKVSGag-Pol polyprotein3.4.23.160.440
3r9hZ67Cyclin-dependent kinase 22.7.11.220.440
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.440
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4g1wG1WMitogen-activated protein kinase 82.7.11.240.440
4qgiROCGag-Pol polyprotein3.4.23.160.440