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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.17

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.171.000
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.626
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.617
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.593
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.588
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.572
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.536
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.521
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.512
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.507
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.499
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.499
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.491
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.489
4ajgF07cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.486
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.483
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.480
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.480
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.474
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.471
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.470
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.467
4htx19FcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.463
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.462
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.462
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
3v94WYQPhosphodiesterase/0.460
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.460
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.459
3g4lROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.457
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.456
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
4phlPILPhosphodiesterase/0.441