sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4hej | 14D | Thymidylate kinase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4hej | 14D | Thymidylate kinase | / | 1.000 | |
| 4gsy | 0Y5 | Thymidylate kinase | / | 0.675 | |
| 4hld | 16T | Thymidylate kinase | / | 0.559 | |
| 3qpg | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.473 | |
| 2ejz | SAH | Diphthine synthase | / | 0.471 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.471 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.462 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.457 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.453 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.452 | |
| 4g1n | NZT | Pyruvate kinase PKM | 2.7.1.40 | 0.452 | |
| 3p0f | BAU | Uridine phosphorylase 2 | 2.4.2.3 | 0.451 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.450 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.449 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.449 | |
| 4h6z | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.447 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2zev | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.446 | |
| 3l05 | SN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.446 | |
| 5ej4 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.446 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.446 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.445 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3ug8 | IMN | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4drj | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.445 | |
| 4drj | RAP | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.445 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.444 | |
| 3ikt | NAD | Redox-sensing transcriptional repressor Rex | / | 0.444 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1t4c | COA | Formyl-CoA:oxalate CoA-transferase | / | 0.443 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.443 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1pr0 | NOS | Purine nucleoside phosphorylase DeoD-type | / | 0.441 | |
| 1ahg | TYR_PLP | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 |