Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4hdr | DMD | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4hdr | DMD | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase | / | 1.000 | |
| 4hdr | DMD | ArsB | / | 1.000 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.534 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.520 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.509 | |
| 3f0a | ACO | Spermidine N(1)-acetyltransferase | / | 0.506 | |
| 1f4g | TP4 | Thymidylate synthase | / | 0.502 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.501 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.501 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.498 | |
| 2cy2 | ACO | Probable acetyltransferase | / | 0.498 | |
| 4a0s | CO8 | Octenoyl-CoA reductase/carboxylase | / | 0.498 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.497 | |
| 3p9t | TCL | Repressor | / | 0.497 | |
| 4imo | PWZ | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.495 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.494 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.494 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.493 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.493 | |
| 1uml | FR4 | Adenosine deaminase | 3.5.4.4 | 0.493 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.492 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.491 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.491 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.491 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.490 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.490 | |
| 3qly | 55V | Uncharacterized protein | / | 0.490 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.490 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.489 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.488 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.488 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.488 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.487 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.486 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.486 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.486 | |
| 3up0 | D7S | aceDAF-12 | / | 0.486 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.485 | |
| 2mm3 | CHO | Gastrotropin | / | 0.485 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.485 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.484 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.484 | |
| 4bvn | P32 | Beta-1 adrenergic receptor | / | 0.484 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.484 | |
| 1e1n | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.483 | |
| 1zpr | CB3 | Thymidylate synthase | / | 0.483 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.483 | |
| 4ddr | MMV | Dihydrofolate reductase | 1.5.1.3 | 0.483 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.482 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.482 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.482 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.481 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.481 | |
| 1cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.480 | |
| 3wg6 | NDP | NADPH-dependent conjugated polyketone reductase C1 | / | 0.480 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 4eb4 | D16 | Thymidylate synthase | 2.1.1.45 | 0.480 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.480 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.480 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.479 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.479 | |
| 2jn3 | JN3 | Fatty acid-binding protein, liver | / | 0.479 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.479 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.478 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.478 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.478 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.478 | |
| 3fu8 | 3DM | Laccase-1 | 1.10.3.2 | 0.478 | |
| 3fu9 | KIB | Laccase-1 | 1.10.3.2 | 0.478 | |
| 3sf6 | FDA | Glutaryl-CoA dehydrogenase | / | 0.478 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.478 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.477 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.477 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 4hkf | ACO | Alpha-tubulin N-acetyltransferase 1 | / | 0.477 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.476 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.476 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.476 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.476 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.476 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.476 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.475 | |
| 1ly4 | COQ | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.475 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 3kjs | DQ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.475 | |
| 3s7a | 684 | Dihydrofolate reductase | 1.5.1.3 | 0.475 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.475 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.475 | |
| 4xwt | U5P | Ribonuclease J | / | 0.475 | |
| 1fwm | CB3 | Thymidylate synthase | / | 0.474 | |
| 1ia2 | TQ4 | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.474 | |
| 3e5a | VX6 | Aurora kinase A | 2.7.11.1 | 0.474 | |
| 3gl2 | D3M | DdmC | / | 0.474 | |
| 3jsu | KA5 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.474 | |
| 1pow | FAD | Pyruvate oxidase | 1.2.3.3 | 0.473 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1tw2 | ERT | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.473 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.473 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.473 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.472 | |
| 1jxz | BCA | 4-chlorobenzoyl coenzyme A dehalogenase | 3.8.1.7 | 0.472 | |
| 1kzi | THG | Thymidylate synthase | / | 0.472 | |
| 2kce | D16 | Thymidylate synthase | / | 0.472 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.472 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.472 | |
| 3iel | U5P | Ribonuclease TTHA0252 | 3.1 | 0.472 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.472 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.472 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.472 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 2ntj | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.471 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 3gph | OID | Cytochrome P450 2E1 | 1.14.13 | 0.471 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.471 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.471 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.471 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.471 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.471 | |
| 1sre | HAB | Streptavidin | / | 0.470 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 2fzi | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.470 | |
| 2imf | TOM | 2-hydroxychromene-2-carboxylate isomerase | 5.99.1.4 | 0.470 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.470 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.470 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.470 | |
| 1sqp | MYX | Cytochrome b | / | 0.469 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.469 | |
| 2tsc | CB3 | Thymidylate synthase | / | 0.469 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 3rus | ADP | Chaperonin | / | 0.469 | |
| 3tdl | 11D | Serum albumin | / | 0.469 | |
| 4amj | CVD | Beta-1 adrenergic receptor | / | 0.469 | |
| 4h97 | 53S | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 4yfy | 0FX | VioF | / | 0.469 | |
| 1aiq | CB3 | Thymidylate synthase | / | 0.468 | |
| 1e90 | MYC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.468 | |
| 1rxh | BNI | Streptavidin | / | 0.468 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.468 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.468 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 1ly3 | COG | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.467 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.467 | |
| 2qmz | LDP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.467 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.467 | |
| 3thr | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.467 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.466 | |
| 1x7h | NDP | Putative ketoacyl reductase | 1.3.1 | 0.466 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.466 | |
| 3fhx | PXL | Pyridoxal kinase | 2.7.1.35 | 0.466 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.466 | |
| 4jlk | 1NO | Deoxycytidine kinase | 2.7.1.74 | 0.466 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.466 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.465 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.465 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.465 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.465 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.465 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.465 | |
| 2qmy | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.465 | |
| 2x6o | 2TC | Tetracycline repressor protein class D | / | 0.465 | |
| 2xvv | 9DN | Serum albumin | / | 0.465 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.465 | |
| 3eej | 53R | Uncharacterized protein | / | 0.465 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.465 | |
| 4e0i | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.465 | |
| 4o71 | CPB | Bromodomain-containing protein 4 | / | 0.465 | |
| 1fml | RTL | Retinol dehydratase | / | 0.464 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2vcg | S17 | Histone deacetylase-like amidohydrolase | 3.5.1 | 0.464 | |
| 3d5q | T30 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3k2h | LYA | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.464 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.464 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.464 | |
| 4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.464 | |
| 4okt | 198 | Androgen receptor | / | 0.464 | |
| 4wo5 | 324 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.464 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.463 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.463 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 1s3v | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.463 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.463 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.463 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.463 | |
| 2j3j | HC4 | NADPH-dependent oxidoreductase 2-alkenal reductase | 1.3.1.74 | 0.463 | |
| 3b9l | AZZ | Serum albumin | / | 0.463 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.463 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.463 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.463 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.463 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.463 | |
| 4kxj | P34 | Nucleoprotein | / | 0.463 | |
| 4mxe | ACO | N-acetyltransferase ESCO1 | 2.3.1 | 0.463 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 1tys | DHF | Thymidylate synthase | / | 0.462 | |
| 1zx1 | CB1 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.462 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.462 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.462 | |
| 2ntv | P1H | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.462 | |
| 2wpw | ACO | Orf14 | / | 0.462 | |
| 2wpx | ACO | Orf14 | / | 0.462 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.462 | |
| 3dok | GWJ | Pol protein | / | 0.462 | |
| 3eei | MTM | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.462 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.462 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.462 | |
| 4qbi | AP5 | Adenylate kinase | / | 0.462 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.462 | |
| 1j3i | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 1ndy | FR3 | Adenosine deaminase | 3.5.4.4 | 0.461 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.461 | |
| 2f8p | CEI | Obelin | / | 0.461 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.461 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 3b8q | 900 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.461 | |
| 3qh2 | 3NM | Thiazole tautomerase | / | 0.461 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.461 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.461 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 5kf2 | ACO | Predicted acetyltransferase | / | 0.461 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.461 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.460 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.460 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.460 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.460 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 3bsy | ACO | UDP-N-acetylbacillosamine N-acetyltransferase | 2.3.1.203 | 0.460 | |
| 3g1o | RF1 | HTH-type transcriptional regulator EthR | / | 0.460 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.460 | |
| 4a4x | JUP | Serine/threonine-protein kinase Nek2 | 2.7.11.1 | 0.460 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 4ixf | IXF | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.459 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.459 | |
| 3cse | N22 | Uncharacterized protein | / | 0.459 | |
| 3l71 | AZO | Cytochrome b | / | 0.459 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.459 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.459 | |
| 4jlt | 8PR | Cytochrome P450 2B4 | 1.14.14.1 | 0.459 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.459 | |
| 4qa1 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.459 | |
| 1ie9 | VDX | Vitamin D3 receptor | / | 0.458 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.458 | |
| 2b35 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.458 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.458 | |
| 2w98 | P1Z | Prostaglandin reductase 2 | 1.3.1.48 | 0.458 | |
| 3dga | RJ1 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.458 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 3qlx | QLR | Uncharacterized protein | / | 0.458 | |
| 3up3 | XCA | aceDAF-12 | / | 0.458 | |
| 3w0u | HPW | Lactoylglutathione lyase | 4.4.1.5 | 0.458 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.458 | |
| 4bfp | SWY | Tankyrase-2 | 2.4.2.30 | 0.458 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.458 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.458 | |
| 4jl6 | ADP | Adenylate kinase | / | 0.458 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.458 | |
| 4qoe | FAD | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.458 | |
| 3pwh | ZMA | Adenosine receptor A2a | / | 0.458 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.457 | |
| 1wxy | FRK | Adenosine deaminase | 3.5.4.4 | 0.457 | |
| 1xds | DRA | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.457 | |
| 2bf7 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.457 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.457 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.457 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.457 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.457 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4iwv | 1J9 | Glucokinase | 2.7.1.2 | 0.457 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.457 | |
| 4y8v | ADP | Acyl-CoA synthetase (NDP forming) | / | 0.457 | |
| 4ykg | NAD | Alkyl hydroperoxide reductase subunit F | 1.8.1 | 0.457 | |
| 1a27 | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.456 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.456 | |
| 2rtg | BTN | Streptavidin | / | 0.456 | |
| 3arv | SAU | Chitinase A | / | 0.456 | |
| 3g5h | YTT | Mycocyclosin synthase | 1.14.21.9 | 0.456 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.456 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.456 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.456 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.456 | |
| 3s41 | S41 | Glucokinase | 2.7.1.2 | 0.456 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.456 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.456 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.456 | |
| 1e7a | PFL | Serum albumin | / | 0.455 | |
| 1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.455 | |
| 1sqb | AZO | Cytochrome b | / | 0.455 | |
| 2bfm | TOP | Pteridine reductase 1 | 1.5.1.33 | 0.455 | |
| 2igx | A1T | Plasmepsin 2 | / | 0.455 | |
| 2wuu | NHW | Glycylpeptide N-tetradecanoyltransferase | / | 0.455 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.455 | |
| 3lak | KR1 | Gag-Pol polyprotein | 2.7.7.49 | 0.455 | |
| 3q0v | LL4 | HTH-type transcriptional regulator EthR | / | 0.455 | |
| 3upk | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.455 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.455 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.455 | |
| 1dls | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1vj3 | TAB | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.454 | |
| 2ewa | SB2 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.454 | |
| 4nqg | CZH | Mitrocomin | / | 0.454 | |
| 4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.454 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.454 | |
| 4y1b | NAP | AntE | / | 0.454 | |
| 5ab6 | CAA | Nonspecific lipid-transfer protein, putative | / | 0.454 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.453 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.453 | |
| 2i0z | FAD | NAD(FAD)-utilizing dehydrogenases | / | 0.453 | |
| 3d4b | DZD | NAD-dependent protein deacetylase | / | 0.453 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.453 | |
| 3uba | HC4 | Lactoperoxidase | 1.11.1.7 | 0.453 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.453 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.453 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 4b4b | GJB | Glucose-1-phosphate thymidylyltransferase | / | 0.453 | |
| 4fog | C2F | Thymidylate synthase ThyA | / | 0.453 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.453 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1e92 | HBI | Pteridine reductase 1 | 1.5.1.33 | 0.452 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.452 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.452 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.452 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.452 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.452 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3lq2 | TDP | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.452 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.452 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.452 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.452 | |
| 4at5 | MUJ | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.452 | |
| 4ge4 | 0KE | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.452 | |
| 4k9y | K9Y | Focal adhesion kinase 1 | 2.7.10.2 | 0.452 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.452 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.452 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1fel | FEN | Retinol-binding protein 4 | / | 0.451 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.451 | |
| 1q13 | TES | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.451 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.451 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.451 | |
| 2b36 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 2hj3 | FAD | FAD-linked sulfhydryl oxidase ERV1 | / | 0.451 | |
| 3bhl | THG | Thymidylate synthase | / | 0.451 | |
| 3dpd | 41A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.451 | |
| 3dya | PZL | Gag-Pol polyprotein | 2.7.7.49 | 0.451 | |
| 4at0 | FAD | Possible succinate dehydrogenase | / | 0.451 | |
| 4gn6 | TYL | Lactoperoxidase | 1.11.1.7 | 0.451 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4oxy | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.451 | |
| 4ami | G90 | Beta-1 adrenergic receptor | / | 0.451 | |
| 1d2s | DHT | Sex hormone-binding globulin | / | 0.450 | |
| 1eio | GCH | Gastrotropin | / | 0.450 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.450 | |
| 1rdt | L79 | Retinoic acid receptor RXR-alpha | / | 0.450 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1uag | UMA | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.450 | |
| 1uhh | CZP | Aequorin-2 | / | 0.450 | |
| 1vza | UMP | Thymidylate synthase | / | 0.450 | |
| 2hl0 | A3S | Threonine--tRNA ligase | 6.1.1.3 | 0.450 | |
| 2vnh | FAD | NADPH:ferredoxin reductase | / | 0.450 | |
| 2x23 | TCU | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 3cr7 | PPS | Adenylyl-sulfate kinase | 2.7.1.25 | 0.450 | |
| 3czr | 3CZ | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 3wix | LC3 | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.450 | |
| 4ag7 | COA | Glucosamine 6-phosphate N-acetyltransferase | / | 0.450 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.450 | |
| 4e6a | 0O9 | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 4hx5 | 19V | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.450 | |
| 5kf9 | ACO | Predicted acetyltransferase | / | 0.450 | |
| 4z9g | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.450 | |
| 1an5 | CB3 | Thymidylate synthase | / | 0.449 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1e26 | GPB | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1j3k | WRA | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.449 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.449 | |
| 1oj4 | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.449 | |
| 1s9q | OHT | Estrogen-related receptor gamma | / | 0.449 | |
| 1vzd | CB3 | Thymidylate synthase | / | 0.449 | |
| 1w22 | NHB | Histone deacetylase 8 | 3.5.1.98 | 0.449 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.449 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.449 | |
| 2bfp | H4B | Pteridine reductase 1 | 1.5.1.33 | 0.449 | |
| 2bun | FAD | AppA protein | / | 0.449 | |
| 2fzh | DH1 | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.449 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.449 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.449 | |
| 2za0 | MGI | Lactoylglutathione lyase | 4.4.1.5 | 0.449 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3fco | IIG | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.449 | |
| 3vt6 | 5YI | Vitamin D3 receptor | / | 0.449 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.449 | |
| 4gi4 | 0EX | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.449 | |
| 4h4m | 494 | Gag-Pol polyprotein | 2.7.7.49 | 0.449 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.449 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.449 | |
| 4kw5 | 1W6 | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.449 | |
| 4u9v | ACO | N-alpha-acetyltransferase 40 | 2.3.1 | 0.449 | |
| 5bvw | 1N1 | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.449 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.449 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.449 | |
| 2ycy | P32 | Beta-1 adrenergic receptor | / | 0.449 | |
| 1g3m | PCQ | Estrogen sulfotransferase | 2.8.2.4 | 0.448 | |
| 1kt6 | RTL | Retinol-binding protein 4 | / | 0.448 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.448 | |
| 1sqi | 869 | 4-hydroxyphenylpyruvate dioxygenase | / | 0.448 | |
| 1uhl | MEI | Retinoic acid receptor RXR-beta | / | 0.448 | |
| 1v5e | FAD | Pyruvate oxidase | / | 0.448 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.448 | |
| 2xc3 | RT8 | Steroid C26-monooxygenase | 1.14.13.141 | 0.448 | |
| 3d80 | Q22 | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.448 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.448 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.448 | |
| 3w5r | LOA | Vitamin D3 receptor | / | 0.448 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.448 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.448 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 1hv9 | UD1 | Bifunctional protein GlmU | / | 0.447 | |
| 1kl2 | FON | Serine hydroxymethyltransferase | / | 0.447 | |
| 1kyz | FER | Caffeic acid 3-O-methyltransferase | 2.1.1.68 | 0.447 | |
| 1m7a | MQU | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.447 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.447 | |
| 1srg | MHB | Streptavidin | / | 0.447 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3aba | FLI | Cytochrome P450 | / | 0.447 | |
| 3fmz | 2T1 | Retinol-binding protein 4 | / | 0.447 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.447 | |
| 3tgu | WF3 | Cytochrome b | / | 0.447 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.447 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 4bms | NAP | Alclohol dehydrogenase/short-chain dehydrogenase | / | 0.447 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.447 | |
| 4qkn | JMS | Alpha-ketoglutarate-dependent dioxygenase FTO | / | 0.447 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.447 | |
| 1srf | MTB | Streptavidin | / | 0.446 | |
| 2cle | F6F | Tryptophan synthase alpha chain | / | 0.446 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 2jfh | LK1 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.446 | |
| 2p4i | MR9 | Angiopoietin-1 receptor | 2.7.10.1 | 0.446 | |
| 2uxp | CLM | HTH-type transcriptional regulator TtgR | / | 0.446 | |
| 2ync | YNC | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 3ec7 | NAD | Inositol 2-dehydrogenase | / | 0.446 | |
| 3ezp | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.446 | |
| 3n0y | APC | Adenylate cyclase 2 | / | 0.446 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.446 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.446 | |
| 4boe | CLR | Japanin | / | 0.446 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.446 | |
| 4jl5 | ADP | Adenylate kinase | / | 0.446 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.446 | |
| 4lb2 | DM5 | Serum albumin | / | 0.446 | |
| 5dp2 | NAP | CurF | / | 0.446 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.446 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1ia4 | TQ6 | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.445 | |
| 2dji | FAD | Pyruvate oxidase | / | 0.445 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 2rab | NAD | Glutathione amide reductase | / | 0.445 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.445 | |
| 2xw7 | NDP | Dihydrofolate reductase | / | 0.445 | |
| 2yw9 | NAP | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.445 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.445 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3eek | 53S | Uncharacterized protein | / | 0.445 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.445 | |
| 3qk0 | QK0 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.445 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.445 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.445 | |
| 3vev | 0H4 | Glucokinase | 2.7.1.2 | 0.445 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
| 4hai | I23 | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.445 | |
| 4l23 | X6K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | / | 0.445 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.445 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.445 | |
| 5kf2 | COA | Predicted acetyltransferase | / | 0.445 | |
| 5kgj | ACO | Predicted acetyltransferase | / | 0.445 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.444 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.444 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.444 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.444 | |
| 1jut | LYD | Thymidylate synthase | / | 0.444 | |
| 1pw1 | HEL | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.444 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.444 | |
| 1sqq | OST | Cytochrome b | / | 0.444 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.444 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.444 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.444 | |
| 2qjp | SMA | Cytochrome b | / | 0.444 | |
| 3ddw | 055 | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.444 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3e01 | PZ2 | Gag-Pol polyprotein | 2.7.7.49 | 0.444 | |
| 3g1m | RF3 | HTH-type transcriptional regulator EthR | / | 0.444 | |
| 3i1y | 33N | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.444 | |
| 3nhr | RZW | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 3rpn | GTX | Glutathione S-transferase kappa 1 | 2.5.1.18 | 0.444 | |
| 3um8 | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.444 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 4dhy | S41 | Glucokinase | 2.7.1.2 | 0.444 | |
| 4e0h | FAD | Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 1.8.3.2 | 0.444 | |
| 4mry | CEI | Obelin | / | 0.444 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.444 | |
| 4wa9 | AXI | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.444 | |
| 4y9l | FAD | Acyl-CoA dehydrogenase family member 11 | / | 0.444 | |
| 5kf1 | ACO | Predicted acetyltransferase | / | 0.444 | |
| 1cg6 | MTA | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 1ek2 | CDU | Bifunctional epoxide hydrolase 2 | / | 0.443 | |
| 1fwy | UD1 | Bifunctional protein GlmU | / | 0.443 | |
| 1lhu | EST | Sex hormone-binding globulin | / | 0.443 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.443 | |
| 1rvv | INI | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 1swn | BTN | Streptavidin | / | 0.443 | |
| 1t57 | FMN | Conserved protein | / | 0.443 | |
| 1uwh | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.443 | |
| 1zaf | 789 | Estrogen receptor beta | / | 0.443 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.443 | |
| 2bo7 | GDP | Mannosylglycerate synthase | / | 0.443 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.443 | |
| 2rl5 | 2RL | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.443 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.443 | |
| 2y03 | 5FW | Beta-1 adrenergic receptor | / | 0.443 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.443 | |
| 3bzu | A21 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 3cop | ADP | Glycogen synthase | 2.4.1.21 | 0.443 | |
| 3g5s | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.443 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.443 | |
| 3o8g | O8G | HTH-type transcriptional regulator EthR | / | 0.443 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.443 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.443 | |
| 3tqb | FOL | Dihydrofolate reductase | / | 0.443 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.443 | |
| 3w5q | 3KL | Vitamin D3 receptor | / | 0.443 | |
| 4at8 | ATP | Interleukin enhancer-binding factor 2 | / | 0.443 | |
| 4bch | T7Z | Cyclin-dependent kinase 9 | 2.7.11.22 | 0.443 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.443 | |
| 4ezk | 0SD | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 4fam | 0SZ | Aldo-keto reductase family 1 member C3 | / | 0.443 | |
| 4g1z | 0VP | Vitamin D3 receptor A | / | 0.443 | |
| 4g20 | 484 | Vitamin D3 receptor A | / | 0.443 | |
| 4h98 | 14Q | Uncharacterized protein | / | 0.443 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.443 | |
| 4iah | 1DX | Alr2278 protein | / | 0.443 | |
| 4j03 | FVS | Bifunctional epoxide hydrolase 2 | 3.1.3.76 | 0.443 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.443 | |
| 4mzu | TYD | WxcM-like protein | / | 0.443 | |
| 4rts | SAM | DNA adenine methylase | 2.1.1.72 | 0.443 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1fnd | A2P | Ferredoxin--NADP reductase, chloroplastic | 1.18.1.2 | 0.442 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.442 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.442 | |
| 1mi3 | NAD | NAD(P)H-dependent D-xylose reductase | 1.1.1.307 | 0.442 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.442 | |
| 1ppj | ANY | Cytochrome b | / | 0.442 | |
| 1t1r | IMB | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.442 | |
| 1w4z | NAP | Putative ketoacyl reductase | 1.3.1 | 0.442 | |
| 3caq | NDP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3cd2 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3dej | RXC | Caspase-3 | 3.4.22.56 | 0.442 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.442 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.442 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.442 | |
| 3oct | 1N1 | Tyrosine-protein kinase BTK | 2.7.10.2 | 0.442 | |
| 3otq | MZL | Bifunctional epoxide hydrolase 2 | 3.3.2.10 | 0.442 | |
| 3p9k | CIY | Caffeic acid O-methyltransferase | / | 0.442 | |
| 3py4 | TYL | Lactoperoxidase | 1.11.1.7 | 0.442 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.442 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.442 | |
| 4h95 | 06U | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 4rxq | DUT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.442 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.442 | |
| 5ckw | ANP | Uncharacterized protein | / | 0.442 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.442 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 1ezf | IN0 | Squalene synthase | 2.5.1.21 | 0.441 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 1tlc | F89 | Thymidylate synthase | / | 0.441 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 1v79 | FR7 | Adenosine deaminase | 3.5.4.4 | 0.441 | |
| 1w78 | PD8 | Dihydrofolate synthase/folylpolyglutamate synthase | 6.3.2.12 | 0.441 | |
| 1wp4 | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.441 | |
| 1wsv | THH | Aminomethyltransferase, mitochondrial | / | 0.441 | |
| 1zid | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2a4n | COA | Aac(6')-Ii protein | / | 0.441 | |
| 2has | C3O | Vitamin D3 receptor | / | 0.441 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.441 | |
| 2vqo | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.441 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.441 | |
| 2z4w | 749 | Geranylgeranyl pyrophosphate synthase | / | 0.441 | |
| 3ch6 | 311 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.441 | |
| 3eem | 53V | Uncharacterized protein | / | 0.441 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3gan | SVR | Protein RDM1 | / | 0.441 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 3rga | ILD | Epoxide hydrolase LasB | 5.5.1 | 0.441 | |
| 3vt9 | YI4 | Vitamin D3 receptor | / | 0.441 | |
| 4a6e | ASE | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.441 | |
| 4dch | 4DC | Glucokinase | 2.7.1.2 | 0.441 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.441 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.441 | |
| 4glx | 0XS | DNA ligase | 6.5.1.2 | 0.441 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.441 | |
| 4lt6 | 3AT | Poly(A) polymerase gamma | 2.7.7.19 | 0.441 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.441 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 4phl | PIL | Phosphodiesterase | / | 0.441 | |
| 5epv | ACP | Blue-light-activated histidine kinase | 2.7.13.3 | 0.441 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 5kgp | ACO | Predicted acetyltransferase | / | 0.441 | |
| 1ddu | CB3 | Thymidylate synthase | / | 0.440 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.440 | |
| 1hpu | A12 | Protein UshA | 3.1.3.5 | 0.440 | |
| 1iiu | RTL | Retinol-binding protein 4 | / | 0.440 | |
| 1lhv | NOG | Sex hormone-binding globulin | / | 0.440 | |
| 1nbm | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 1pr4 | MTP | Purine nucleoside phosphorylase DeoD-type | / | 0.440 | |
| 1qnf | HDF | Deoxyribodipyrimidine photo-lyase | 4.1.99.3 | 0.440 | |
| 1sri | DMB | Streptavidin | / | 0.440 | |
| 1u72 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.440 | |
| 2a4z | BYM | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.440 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.440 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.440 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3inv | C50 | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.440 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.440 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.440 | |
| 3qj0 | QI3 | Botulinum neurotoxin type A | 3.4.24.69 | 0.440 | |
| 3qrw | NDP | Putative ketoacyl reductase | 1.3.1 | 0.440 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.440 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.440 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.440 | |
| 4anu | EM7 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4dsb | A8S | Abscisic acid receptor PYL3 | / | 0.440 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.440 | |
| 4jap | COA | Alpha-pyrone synthesis polyketide synthase-like Pks11 | 2.3.1 | 0.440 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.440 | |
| 4trn | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4ug9 | 1EW | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.440 | |
| 4wkb | TDI | 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase | / | 0.440 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.440 | |
| 5kf8 | ACO | Predicted acetyltransferase | / | 0.440 | |
| 5d5b | CAU | Beta-2 adrenergic receptor | / | 0.440 |