sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4h76 | 10B | Macrophage metalloelastase | 3.4.24.65 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4h76 | 10B | Macrophage metalloelastase | 3.4.24.65 | 1.000 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.656 | |
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 0.625 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.625 | |
| 2d1o | FA4 | Stromelysin-1 | 3.4.24.17 | 0.615 | |
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 0.609 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.606 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.602 | |
| 2oxw | ILE_ALA_GLY | Macrophage metalloelastase | 3.4.24.65 | 0.601 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.600 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.600 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.600 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.596 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.593 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.590 | |
| 1g49 | 111 | Stromelysin-1 | 3.4.24.17 | 0.589 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.587 | |
| 2w0d | CGS | Macrophage metalloelastase | 3.4.24.65 | 0.587 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.586 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.585 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.585 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.584 | |
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 0.580 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.578 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.576 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.575 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.575 | |
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 | 0.574 | |
| 1d7x | SPC | Stromelysin-1 | 3.4.24.17 | 0.573 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.569 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.569 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.569 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.568 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.565 | |
| 1sln | INH | Stromelysin-1 | 3.4.24.17 | 0.564 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.560 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.558 | |
| 1d8m | BBH | Stromelysin-1 | 3.4.24.17 | 0.558 | |
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 0.558 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.555 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.549 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.549 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.547 | |
| 1zs0 | EIN | Neutrophil collagenase | 3.4.24.34 | 0.545 | |
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 0.541 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.540 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.540 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.540 | |
| 2ow2 | 8MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.538 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.538 | |
| 4gql | R47 | Macrophage metalloelastase | 3.4.24.65 | 0.533 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.533 | |
| 3oho | Z79 | Stromelysin-1 | 3.4.24.17 | 0.529 | |
| 1c8t | TR1 | Stromelysin-1 | 3.4.24.17 | 0.525 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.525 | |
| 3i7i | 518 | Collagenase 3 | 3.4.24 | 0.524 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.523 | |
| 1b3d | S27 | Stromelysin-1 | 3.4.24.17 | 0.515 | |
| 1hv5 | RXP | Stromelysin-3 | 3.4.24 | 0.514 | |
| 2y6d | TQJ | Matrilysin | 3.4.24.23 | 0.505 | |
| 2woa | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.500 | |
| 1hov | I52 | 72 kDa type IV collagenase | 3.4.24.24 | 0.499 | |
| 1gkc | NFH | Matrix metalloproteinase-9 | 3.4.24.35 | 0.498 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.497 | |
| 1bzs | BSI | Neutrophil collagenase | 3.4.24.34 | 0.496 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.494 | |
| 1fm1 | WAY | Collagenase 3 | 3.4.24 | 0.492 | |
| 2wo9 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.488 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.485 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.485 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.483 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.482 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.481 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.481 | |
| 2rjp | 886 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | 3.4.24.82 | 0.479 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.475 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.474 | |
| 3aig | 0ZC | Snake venom metalloproteinase adamalysin-2 | 3.4.24.46 | 0.474 | |
| 3eku | CY9 | Actin-5C | / | 0.473 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.473 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.472 | |
| 2zts | ADP | Uncharacterized protein | / | 0.470 | |
| 3mp5 | HMG | Hydroxymethylglutaryl-CoA lyase, mitochondrial | 4.1.3.4 | 0.470 | |
| 2zu8 | GDD | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.469 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.468 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.467 | |
| 4rx6 | ATP | Nitrogen regulatory PII-like protein | / | 0.467 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.466 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.466 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.466 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.466 | |
| 2g78 | REA | Cellular retinoic acid-binding protein 2 | / | 0.465 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.465 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1mnc | PLH | Neutrophil collagenase | 3.4.24.34 | 0.464 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.464 | |
| 2e16 | SAH | Diphthine synthase | / | 0.463 | |
| 2ejz | SAH | Diphthine synthase | / | 0.463 | |
| 2oy2 | ILE_ALA_GLY | Neutrophil collagenase | 3.4.24.34 | 0.463 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.463 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.463 | |
| 4xd2 | NAI | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.463 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.462 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.462 | |
| 3eks | CY9 | Actin-5C | / | 0.462 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.462 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.461 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.461 | |
| 1svl | ADP | Large T antigen | 3.6.4 | 0.461 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.461 | |
| 2nua | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.461 | |
| 2owf | SAH | Diphthine synthase | / | 0.461 | |
| 2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.461 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.461 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4er6 | AW2 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | 2.1.1.43 | 0.461 | |
| 4tl8 | AGS | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.461 | |
| 2owg | SAH | Diphthine synthase | / | 0.460 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.460 | |
| 3ge6 | FMN | Nitroreductase | / | 0.460 | |
| 3v2u | ATP | Protein GAL3 | / | 0.460 | |
| 5eja | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.460 | |
| 1biw | S80 | Stromelysin-1 | 3.4.24.17 | 0.459 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 2c27 | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.459 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.459 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.459 | |
| 4tm1 | FDA | KtzI | / | 0.459 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.459 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.458 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.458 | |
| 1yqz | COA | Coenzyme A disulfide reductase | / | 0.458 | |
| 2clq | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.458 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.458 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.458 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.458 | |
| 4avl | TMP | Polymerase acidic protein | / | 0.458 | |
| 1adf | TAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.457 | |
| 1qvn | FRI | Interleukin-2 | / | 0.457 | |
| 1wng | SAH | Diphthine synthase | / | 0.457 | |
| 2p9d | SAH | Diphthine synthase | / | 0.457 | |
| 2wo8 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.457 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.457 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.457 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.456 | |
| 1mv8 | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.456 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.456 | |
| 2hg1 | N5O | Endoplasmin | / | 0.456 | |
| 3cne | FMN | Putative protease I | / | 0.456 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.456 | |
| 1eag | A70 | Candidapepsin-2 | 3.4.23.24 | 0.455 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.455 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3ieu | GDP | GTPase Era | / | 0.455 | |
| 1gpd | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.454 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.454 | |
| 2pb4 | SAH | Diphthine synthase | / | 0.454 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.454 | |
| 3cbs | R12 | Cellular retinoic acid-binding protein 2 | / | 0.454 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.454 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.454 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.453 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.453 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.453 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.453 | |
| 2hux | SAH | Diphthine synthase | / | 0.453 | |
| 3dck | KVI | Protease | / | 0.453 | |
| 3lki | ATP | Fructokinase | / | 0.453 | |
| 3oix | FMN | Dihydroorotate dehydrogenase | / | 0.453 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.453 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.452 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.452 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.452 | |
| 2xzw | ATP | Nitrogen regulatory protein P-II | / | 0.452 | |
| 3clr | FAD | Electron transfer flavoprotein subunit alpha | / | 0.452 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.452 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.452 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.452 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.452 | |
| 1d5j | MM3 | Stromelysin-1 | 3.4.24.17 | 0.451 | |
| 1men | GAR | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.451 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.451 | |
| 2jiz | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.451 | |
| 2p6k | SAH | Diphthine synthase | / | 0.451 | |
| 2y65 | ADP | Kinesin heavy chain | / | 0.451 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.451 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.450 | |
| 1rm8 | BAT | Matrix metalloproteinase-16 | 3.4.24 | 0.450 | |
| 2e8q | SAH | Diphthine synthase | / | 0.450 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.450 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 2vwh | NAP | Glucose 1-dehydrogenase | / | 0.450 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.450 | |
| 4b63 | FAD | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4die | C5P | Cytidylate kinase | / | 0.450 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.450 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.450 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.450 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.450 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.449 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.449 | |
| 2y3s | TIR | TamL | / | 0.449 | |
| 2z6r | SAH | Diphthine synthase | / | 0.449 | |
| 3el4 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.449 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4dta | ADN | APH(2'')-Id | / | 0.449 | |
| 4wuo | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.449 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 2dv4 | SAH | Diphthine synthase | / | 0.448 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.448 | |
| 2hut | SAH | Diphthine synthase | / | 0.448 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.448 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.448 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.448 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.448 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.448 | |
| 1dth | BAT | Snake venom metalloproteinase atrolysin-D | 3.4.24.42 | 0.447 | |
| 1e1q | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.447 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1s1p | NAP | Aldo-keto reductase family 1 member C3 | / | 0.447 | |
| 2e08 | SAH | Diphthine synthase | / | 0.447 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.447 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.447 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2vnk | FAD | NADPH:ferredoxin reductase | / | 0.447 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.447 | |
| 3s1a | ATP | Circadian clock protein kinase KaiC | 2.7.11.1 | 0.447 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.447 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.447 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.447 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 4m55 | NAD | UDP-glucuronic acid decarboxylase 1 | 4.1.1.35 | 0.447 | |
| 5ify | UMP | Glucose-1-phosphate thymidylyltransferase | / | 0.447 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.446 | |
| 1i3m | UD1 | UDP-glucose 4-epimerase | / | 0.446 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.446 | |
| 1n2v | BDI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.446 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.446 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2dv7 | SAH | Diphthine synthase | / | 0.446 | |
| 2eeq | SAH | Diphthine synthase | / | 0.446 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.446 | |
| 2jih | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | 3.4.24 | 0.446 | |
| 2p6l | SAH | Diphthine synthase | / | 0.446 | |
| 2y3r | TRK | TamL | / | 0.446 | |
| 3cvk | N34 | Genome polyprotein | 2.7.7.48 | 0.446 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3em6 | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3lzu | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.446 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.446 | |
| 1fgc | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.445 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1u0w | STL | Chalcone synthase 2 | 2.3.1.74 | 0.445 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.445 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.445 | |
| 2gfd | RDA | Endoplasmin | / | 0.445 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.445 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.445 | |
| 2q54 | MU1 | Protease | / | 0.445 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.445 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.445 | |
| 4ef8 | FMN | Dihydroorotate dehydrogenase (fumarate) | / | 0.445 | |
| 4h2n | FAD | 2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase | / | 0.445 | |
| 4hj6 | FMN | LOV protein | / | 0.445 | |
| 4is3 | NAD | 3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 | 1.17.98.1 | 0.445 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.445 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.444 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.444 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.444 | |
| 1soz | VAL_TYR_GLN_PHE | Serine endoprotease DegS | 3.4.21.107 | 0.444 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 1vce | SAH | Diphthine synthase | / | 0.444 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.444 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.444 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.444 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.444 | |
| 3ijo | B4D | Glutamate receptor 2 | / | 0.444 | |
| 3sj7 | NDP | 3-oxoacyl-(Acyl-carrier-protein) reductase, putative | / | 0.444 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.444 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.444 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.444 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4fj1 | NAP | 17beta-hydroxysteroid dehydrogenase | / | 0.444 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.443 | |
| 1fej | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.443 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1wwk | NAD | 307aa long hypothetical phosphoglycerate dehydrogenase | / | 0.443 | |
| 1zxc | IH6 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.443 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.443 | |
| 2ed5 | SAH | Diphthine synthase | / | 0.443 | |
| 2egl | SAH | Diphthine synthase | / | 0.443 | |
| 2p5c | SAH | Diphthine synthase | / | 0.443 | |
| 3bjc | WAN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.443 | |
| 3k4c | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.443 | |
| 3nbv | ANP | Ketohexokinase | / | 0.443 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 4frj | DWB | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.443 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.442 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.442 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.442 | |
| 2cig | 1DG | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 2cvz | NDP | 3-hydroxyisobutyrate dehydrogenase | / | 0.442 | |
| 2owv | SAH | Diphthine synthase | / | 0.442 | |
| 2rbe | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 2ww4 | ADP | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | 2.7.1.148 | 0.442 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.442 | |
| 2yxu | ATP | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 3had | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 3i59 | N6S | CRP-like cAMP-activated global transcriptional regulator | / | 0.442 | |
| 3o9i | A61 | Gag-Pol polyprotein | / | 0.442 | |
| 3q8h | AO9 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.442 | |
| 4cax | 646 | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.442 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4oh4 | ANP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.442 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.442 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.442 | |
| 4zow | CLM | Multidrug transporter MdfA | / | 0.442 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.442 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.441 | |
| 1uop | GLY_PHE_GLU_PRO | Prolyl endopeptidase | 3.4.21.26 | 0.441 | |
| 2d4v | NAD | Isocitrate dehydrogenase [NADP] | / | 0.441 | |
| 2el0 | SAH | Diphthine synthase | / | 0.441 | |
| 2gz7 | D3F | Orf1a polyprotein | / | 0.441 | |
| 2hen | ADP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.441 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.441 | |
| 2psw | COA | N-alpha-acetyltransferase 50 | / | 0.441 | |
| 2q63 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.441 | |
| 2y1t | DUD | SPBc2 prophage-derived deoxyuridine 5'-triphosphate nucleotidohydrolase YosS | 3.6.1.23 | 0.441 | |
| 2z6c | FMN | Phototropin-1 | 2.7.11.1 | 0.441 | |
| 3gy0 | NAP | NAD(P)-dependent oxidoreductase | / | 0.441 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.441 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3vf7 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 4asu | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.441 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.441 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4l4x | NDP | AmphI | / | 0.441 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.441 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.440 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 1rp0 | AHZ | Thiamine thiazole synthase, chloroplastic | / | 0.440 | |
| 1tys | TMP | Thymidylate synthase | / | 0.440 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.440 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.440 | |
| 2db3 | ANP | ATP-dependent RNA helicase vasa, isoform A | 3.6.4.13 | 0.440 | |
| 2dsg | SAH | Diphthine synthase | / | 0.440 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.440 | |
| 2hld | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.440 | |
| 2hld | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.440 | |
| 2qfo | A51 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2w2l | NAD | D-mandelate dehydrogenase | / | 0.440 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.440 | |
| 3csc | ACO | Citrate synthase, mitochondrial | 2.3.3.1 | 0.440 | |
| 3dr8 | ACO | L-methionine sulfoximine/L-methionine sulfone acetyltransferase | / | 0.440 | |
| 3m6i | NAD | L-arabinitol 4-dehydrogenase | 1.1.1.12 | 0.440 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3sa5 | A69 | Protease | / | 0.440 | |
| 3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.440 | |
| 4h3i | 10V | Beta-secretase 1 | 3.4.23.46 | 0.440 |