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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.10

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4h5eYS4Farnesyl pyrophosphate synthase2.5.1.101.000
4h5dYS4Farnesyl pyrophosphate synthase2.5.1.100.800
4demYS4Farnesyl pyrophosphate synthase2.5.1.100.731
4h5cYS4Farnesyl pyrophosphate synthase2.5.1.100.679
4lfvYS4Farnesyl pyrophosphate synthase2.5.1.100.679
4l2xYL2Farnesyl pyrophosphate synthase2.5.1.100.600
3egt722Farnesyl pyrophosphate synthase/0.590
3iczPB6Farnesyl pyrophosphate synthase/0.575
3dyh721Farnesyl pyrophosphate synthase/0.548
4ga34GAFarnesyl pyrophosphate synthase2.5.1.100.534
3rywK9HFarnesyl pyrophosphate synthase, putative/0.531
2opmNI9Farnesyl pyrophosphate synthase2.5.1.100.517
4jvj1MVFarnesyl pyrophosphate synthase2.5.1.100.496
2oxtSAMGenome polyprotein/0.459
1obbNADAlpha-glucosidase3.2.1.200.453
4bfzZVZPantothenate kinase2.7.1.330.449
5dcyNAPIridoid synthase1.3.1.990.448
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
3em0CHDFatty acid-binding protein 6, ileal (gastrotropin)/0.444
2f94BFQFarnesyl pyrophosphate synthase2.5.1.100.442