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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4h0nSAHDnmt2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4h0nSAHDnmt2/1.000
3qv2SAH5-cytosine DNA methyltransferase/0.471
7mhtSAHModification methylase HhaI2.1.1.370.454
3pt9SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.451
8mhtSAHModification methylase HhaI2.1.1.370.449
4wxxSAHDNA (cytosine-5)-methyltransferase 12.1.1.370.442
3pt6SAHDNA (cytosine-5)-methyltransferase 12.1.1.370.441
2zcjSAHModification methylase HhaI2.1.1.370.440
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.440
5mhtSAHModification methylase HhaI2.1.1.370.440