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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.301.000
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.546
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.543
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.516
4hhz15SPoly [ADP-ribose] polymerase 12.4.2.300.511
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.509
3gn73GNPoly [ADP-ribose] polymerase 12.4.2.300.506
3l3mA92Poly [ADP-ribose] polymerase 12.4.2.300.506
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.501
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.500
3l3lL3LPoly [ADP-ribose] polymerase 12.4.2.300.498
4r5wXAVPoly [ADP-ribose] polymerase 12.4.2.300.497
1uk0FRMPoly [ADP-ribose] polymerase 12.4.2.300.496
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.490
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.487
4l6s1WQPoly [ADP-ribose] polymerase 12.4.2.300.479
2rcwAAIPoly [ADP-ribose] polymerase 12.4.2.300.475
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.475
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.468
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.456
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.456
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.453
4fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.452
4fapARDSerine/threonine-protein kinase mTOR2.7.11.10.452
5dsyUHBPoly [ADP-ribose] polymerase 22.4.2.300.449
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.444
1k4mNADNicotinate-nucleotide adenylyltransferase2.7.7.180.442
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.441
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.441
4pnrG18Tankyrase-22.4.2.300.440