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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4gnzNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4gnzNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.61.000
3rhqNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.750
3rhrNDPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.563
1wnbNAIGamma-aminobutyraldehyde dehydrogenase1.2.1.190.557
4i8pNADAminoaldehyde dehydrogenase 1/0.545
3rhjNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.536
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.522
3rhlNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.522
5ez4NADBetaine-aldehyde dehydrogenase/0.521
1a4zNADAldehyde dehydrogenase, mitochondrial1.2.1.30.515
5dibNADBetaine-aldehyde dehydrogenase/0.514
3n82NADAldehyde dehydrogenase, mitochondrial1.2.1.30.504
3v9lNADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.484
1uxuNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.475
1uaeUD1UDP-N-acetylglucosamine 1-carboxyvinyltransferase/0.472
2eitNAD1-pyrroline-5-carboxylate dehydrogenase/0.471
1uxvNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.468
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
4bz7B3NHistone deacetylase/0.445