sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 1.000 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.723 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.666 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.644 | |
| 1g49 | 111 | Stromelysin-1 | 3.4.24.17 | 0.642 | |
| 2w0d | CGS | Macrophage metalloelastase | 3.4.24.65 | 0.637 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.637 | |
| 2d1o | FA4 | Stromelysin-1 | 3.4.24.17 | 0.630 | |
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 0.628 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.626 | |
| 2oxw | ILE_ALA_GLY | Macrophage metalloelastase | 3.4.24.65 | 0.623 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.620 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.613 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.613 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.611 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.610 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.610 | |
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 0.607 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.605 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.602 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.600 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.600 | |
| 1d7x | SPC | Stromelysin-1 | 3.4.24.17 | 0.598 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.598 | |
| 1zs0 | EIN | Neutrophil collagenase | 3.4.24.34 | 0.597 | |
| 4h76 | 10B | Macrophage metalloelastase | 3.4.24.65 | 0.596 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.594 | |
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 | 0.593 | |
| 1sln | INH | Stromelysin-1 | 3.4.24.17 | 0.593 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.593 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.593 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.591 | |
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 0.591 | |
| 1d8m | BBH | Stromelysin-1 | 3.4.24.17 | 0.589 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.589 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.587 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.587 | |
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.587 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.583 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.583 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.581 | |
| 3i7i | 518 | Collagenase 3 | 3.4.24 | 0.580 | |
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 0.580 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.575 | |
| 1hv5 | RXP | Stromelysin-3 | 3.4.24 | 0.575 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.575 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.574 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.573 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.572 | |
| 1gkc | NFH | Matrix metalloproteinase-9 | 3.4.24.35 | 0.570 | |
| 2ow2 | 8MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.569 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.563 | |
| 2wo8 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.562 | |
| 1b3d | S27 | Stromelysin-1 | 3.4.24.17 | 0.561 | |
| 1c8t | TR1 | Stromelysin-1 | 3.4.24.17 | 0.560 | |
| 3oho | Z79 | Stromelysin-1 | 3.4.24.17 | 0.558 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.558 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.558 | |
| 2woa | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.550 | |
| 4gql | R47 | Macrophage metalloelastase | 3.4.24.65 | 0.549 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.544 | |
| 1bzs | BSI | Neutrophil collagenase | 3.4.24.34 | 0.539 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.536 | |
| 1biw | S80 | Stromelysin-1 | 3.4.24.17 | 0.531 | |
| 1rm8 | BAT | Matrix metalloproteinase-16 | 3.4.24 | 0.528 | |
| 3aig | 0ZC | Snake venom metalloproteinase adamalysin-2 | 3.4.24.46 | 0.527 | |
| 1mnc | PLH | Neutrophil collagenase | 3.4.24.34 | 0.525 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.519 | |
| 2wo9 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.513 | |
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.512 | |
| 2dw0 | GM6 | Zinc metalloproteinase-disintegrin-like VAP2B | 3.4.24 | 0.506 | |
| 1hov | I52 | 72 kDa type IV collagenase | 3.4.24.24 | 0.505 | |
| 2y6d | TQJ | Matrilysin | 3.4.24.23 | 0.505 | |
| 1dth | BAT | Snake venom metalloproteinase atrolysin-D | 3.4.24.42 | 0.502 | |
| 2oy2 | ILE_ALA_GLY | Neutrophil collagenase | 3.4.24.34 | 0.502 | |
| 2xs4 | ALA_PHE_THR | Karilysin | 3.4.24 | 0.501 | |
| 1fm1 | WAY | Collagenase 3 | 3.4.24 | 0.500 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.499 | |
| 1zxc | IH6 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.498 | |
| 2xs3 | ALA_PHE_THR_SER | Karilysin | 3.4.24 | 0.498 | |
| 2w13 | WR2 | Snake venom metalloproteinase BaP1 | 3.4.24 | 0.497 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.491 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.491 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.490 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.486 | |
| 1atl | 0QI | Snake venom metalloproteinase atrolysin-D | 3.4.24.42 | 0.484 | |
| 2ix5 | FAD | Acyl-coenzyme A oxidase 4, peroxisomal | 1.3.3.6 | 0.484 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.479 | |
| 3ieu | GDP | GTPase Era | / | 0.479 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.477 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.477 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.477 | |
| 3cuk | FAD | D-amino-acid oxidase | 1.4.3.3 | 0.476 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.475 | |
| 5eso | ISC | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.475 | |
| 3oix | FMN | Dihydroorotate dehydrogenase | / | 0.474 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.473 | |
| 2ejz | SAH | Diphthine synthase | / | 0.473 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.473 | |
| 3ayk | CGS | Interstitial collagenase | 3.4.24.7 | 0.473 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.473 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.473 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.473 | |
| 1d5j | MM3 | Stromelysin-1 | 3.4.24.17 | 0.472 | |
| 3rfa | SAM | Dual-specificity RNA methyltransferase RlmN | / | 0.472 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.471 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.471 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.471 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.471 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.470 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.469 | |
| 2srt | INH | Stromelysin-1 | 3.4.24.17 | 0.469 | |
| 4pl0 | ANP | Microcin-J25 export ATP-binding/permease protein McjD | / | 0.469 | |
| 4tm1 | FDA | KtzI | / | 0.469 | |
| 4zse | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.469 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.468 | |
| 3t88 | S0N | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.468 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.468 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.467 | |
| 2zfn | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.467 | |
| 1rb3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.466 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.466 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.466 | |
| 3l0t | INN | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.466 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.466 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.465 | |
| 3eku | CY9 | Actin-5C | / | 0.465 | |
| 4z61 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.465 | |
| 4z64 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.465 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.464 | |
| 2jih | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | 3.4.24 | 0.464 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.464 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.464 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.464 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.463 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.463 | |
| 2f3f | AXF | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.463 | |
| 3eks | CY9 | Actin-5C | / | 0.463 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.463 | |
| 4gyy | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.463 | |
| 4hj6 | FMN | LOV protein | / | 0.463 | |
| 1w0k | ADP | ATP synthase subunit alpha, mitochondrial | / | 0.462 | |
| 1w0k | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.462 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.462 | |
| 3f63 | GTX | Glutathione transferase GST1-4 | / | 0.462 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.462 | |
| 4fcr | 0TM | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 4rvu | NDP | Probable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) | / | 0.462 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.461 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.461 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.461 | |
| 4acx | S8Z | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.461 | |
| 5hsa | FAS | Alcohol oxidase 1 | 1.1.3.13 | 0.461 | |
| 1rwb | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.460 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.460 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 3kb6 | NAD | D-lactate dehydrogenase | / | 0.460 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.460 | |
| 2ozu | ACO | Histone acetyltransferase KAT6A | / | 0.459 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.459 | |
| 3kmc | 403 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.459 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.459 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.459 | |
| 4l4x | NDP | AmphI | / | 0.459 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 2ydb | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.458 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.458 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4b68 | FAD | L-ornithine N(5)-monooxygenase | / | 0.458 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.458 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.458 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.458 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 1zap | A70 | Candidapepsin-2 | 3.4.23.24 | 0.457 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.457 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 2j83 | BAT | Ulilysin | 3.4.24 | 0.457 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.456 | |
| 1opm | IYG | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.456 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.456 | |
| 4brg | GNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.456 | |
| 4fv7 | E94 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.456 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4nv7 | COA | Arylamine N-acetyltransferase | / | 0.456 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.456 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.455 | |
| 2gou | FMN | NADH:flavin oxidoreductase Sye1 | / | 0.455 | |
| 2hg1 | N5O | Endoplasmin | / | 0.455 | |
| 2zrz | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.455 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.455 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.455 | |
| 5ar4 | SB2 | Receptor-interacting serine/threonine-protein kinase 2 | 2.7.11.1 | 0.455 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.454 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.454 | |
| 2zu8 | GDD | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.454 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.454 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.454 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.454 | |
| 4cf7 | ADP | Adenylate kinase | / | 0.454 | |
| 4ew2 | DXY | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.454 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.453 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.453 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.453 | |
| 2c54 | NAD | GDP-mannose 3,5-epimerase | 5.1.3.18 | 0.453 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 2hr8 | SAH | Diphthine synthase | / | 0.453 | |
| 2nua | COA | Succinate--CoA ligase [ADP-forming] subunit alpha | 6.2.1.5 | 0.453 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.453 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.452 | |
| 1kbi | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.452 | |
| 1knr | FAD | L-aspartate oxidase | 1.4.3.16 | 0.452 | |
| 1mv8 | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.452 | |
| 2g76 | NAD | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.452 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.452 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.452 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.452 | |
| 3dv3 | MEK | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.452 | |
| 3qiy | QI1 | Botulinum neurotoxin type A | 3.4.24.69 | 0.452 | |
| 3vri | 1KX | HLA class I histocompatibility antigen, B-57 alpha chain | / | 0.452 | |
| 3zcs | CAW | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.452 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 4qec | NAP | ElxO | / | 0.452 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.452 | |
| 4z5w | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.452 | |
| 1jpa | ANP | Ephrin type-B receptor 2 | 2.7.10.1 | 0.451 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.451 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.451 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 2b4q | NAP | Rhamnolipids biosynthesis 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.451 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.451 | |
| 2emu | SAH | Diphthine synthase | / | 0.451 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.451 | |
| 3duy | AFJ | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.451 | |
| 3mp5 | HMG | Hydroxymethylglutaryl-CoA lyase, mitochondrial | 4.1.3.4 | 0.451 | |
| 3nbv | ANP | Ketohexokinase | / | 0.451 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.450 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.450 | |
| 1w4a | APC | NTPase P4 | / | 0.450 | |
| 2d81 | RB3 | Poly(3-hydroxybutyrate) depolymerase | / | 0.450 | |
| 2jdt | I5S | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3oqf | S51 | Renin | 3.4.23.15 | 0.450 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.449 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.449 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.449 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.449 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.449 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.449 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.449 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.449 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.449 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.449 | |
| 3ohf | 3HF | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.449 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 4ih7 | 1ER | Genome polyprotein | 2.7.7.48 | 0.449 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.449 | |
| 5cdt | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.449 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.448 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.448 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.448 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.448 | |
| 2cvj | FAD | Thioredoxin reductase related protein | / | 0.448 | |
| 2dsh | SAH | Diphthine synthase | / | 0.448 | |
| 2eh5 | SAH | Diphthine synthase | / | 0.448 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.448 | |
| 2x19 | GTP | GTP-binding nuclear protein GSP1/CNR1 | / | 0.448 | |
| 3b92 | 440 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.448 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.448 | |
| 3k5f | AYH | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.448 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.448 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.447 | |
| 1hdr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.447 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.447 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.447 | |
| 1pdh | FAS | p-hydroxybenzoate hydroxylase | / | 0.447 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 1tj0 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.447 | |
| 1v9a | SAH | Uncharacterized protein | / | 0.447 | |
| 1vg8 | GNP | Ras-related protein Rab-7a | / | 0.447 | |
| 2c9b | PUG | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.447 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.447 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 2y65 | ADP | Kinesin heavy chain | / | 0.447 | |
| 3fpz | AHZ | Thiamine thiazole synthase | / | 0.447 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.447 | |
| 4ayk | CGS | Interstitial collagenase | 3.4.24.7 | 0.447 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.447 | |
| 4uoh | ADP | Nucleoside diphosphate kinase | / | 0.447 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.447 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 2h2q | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.446 | |
| 2zts | ADP | Uncharacterized protein | / | 0.446 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.446 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.446 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.446 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.446 | |
| 4blr | UTP | NTPase P4 | / | 0.446 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.446 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.446 | |
| 4ozn | ATP | Ammonium transporter | / | 0.446 | |
| 4rx6 | ATP | Nitrogen regulatory PII-like protein | / | 0.446 | |
| 4xd2 | NAI | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.446 | |
| 1bmf | ANP | ATP synthase subunit alpha, mitochondrial | / | 0.445 | |
| 1bmf | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.445 | |
| 1i3l | NAD | UDP-glucose 4-epimerase | / | 0.445 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.445 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.445 | |
| 2hut | SAH | Diphthine synthase | / | 0.445 | |
| 2xyd | 3ES | Angiotensin-converting enzyme | 3.2.1 | 0.445 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.445 | |
| 3gol | XND | Genome polyprotein | 2.7.7.48 | 0.445 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.445 | |
| 3up0 | D7S | aceDAF-12 | / | 0.445 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.445 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4z24 | FAD | Putative GMC-type oxidoreductase R135 | 1 | 0.445 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.444 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1l2t | ATP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.444 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.444 | |
| 2h3w | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.444 | |
| 2owk | SAH | Diphthine synthase | / | 0.444 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.444 | |
| 3bpz | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | / | 0.444 | |
| 3ndj | JHZ | Methyltransferase | / | 0.444 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.444 | |
| 3v2u | ATP | Protein GAL3 | / | 0.444 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.444 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.444 | |
| 6req | 3CP | Methylmalonyl-CoA mutase large subunit | 5.4.99.2 | 0.444 | |
| 3vw7 | VPX | Proteinase-activated receptor 1 | / | 0.444 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.443 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.443 | |
| 1lua | NAP | Bifunctional protein MdtA | 1.5.1.5 | 0.443 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.443 | |
| 1n7g | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.443 | |
| 1t57 | FMN | Conserved protein | / | 0.443 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1v8k | ANP | Kinesin-like protein KIF2C | / | 0.443 | |
| 1w19 | T5P | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 1yhn | GTP | Ras-related protein Rab-7a | / | 0.443 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.443 | |
| 3b9l | AZZ | Serum albumin | / | 0.443 | |
| 3coy | 53H | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 3dd1 | 25D | Glycogen phosphorylase, liver form | 2.4.1.1 | 0.443 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3uyk | 0CX | Probable NDP-rhamnosyltransferase | / | 0.443 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 4pzr | COA | Histone acetyltransferase p300 | / | 0.443 | |
| 5esd | TDP | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.443 | |
| 5jy1 | NAD | Putative short-chain dehydrogenase/reductase | / | 0.443 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.442 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.442 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 1xkq | NDP | Uncharacterized protein | / | 0.442 | |
| 2bd0 | NAP | Sepiapterin reductase | / | 0.442 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.442 | |
| 2dsg | SAH | Diphthine synthase | / | 0.442 | |
| 2e0i | FAD | DNA photolyase | / | 0.442 | |
| 2eh2 | SAH | Diphthine synthase | / | 0.442 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.442 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.442 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.442 | |
| 3gnv | XNZ | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 3iaa | TYD | CalG2 | / | 0.442 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 4em4 | FAD | Coenzyme A disulfide reductase | / | 0.442 | |
| 4j1e | 1HM | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4xgu | ADP | Putative pachytene checkpoint protein 2 | / | 0.442 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.442 | |
| 5jsf | NAD | 17-beta-hydroxysteroid dehydrogenase 14 | 1.1.1 | 0.442 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.441 | |
| 1fml | RTL | Retinol dehydratase | / | 0.441 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.441 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.441 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.441 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.441 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1x1d | SAH | C-20 methyltransferase | / | 0.441 | |
| 2fiw | ACO | GCN5-related N-acetyltransferase:Aminotransferase, class-II | / | 0.441 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.441 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2xhr | C0P | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.441 | |
| 3dck | KVI | Protease | / | 0.441 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3pyz | ANP | Dihydrofolate synthase/folylpolyglutamate synthase | / | 0.441 | |
| 3rku | NAP | NADP-dependent 3-hydroxy acid dehydrogenase | / | 0.441 | |
| 3vuc | HHE | Renin | 3.4.23.15 | 0.441 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.441 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.441 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4cea | ZSW | Integrase | / | 0.441 | |
| 4eh8 | IRG | Mitogen-activated protein kinase 14 | / | 0.441 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.441 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.441 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.441 | |
| 4z3d | NDP | Carbonyl reductase [NADPH] 1 | 1.1.1.184 | 0.441 | |
| 5kjc | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1ae1 | NAP | Tropinone reductase 1 | / | 0.440 | |
| 1ci0 | FMN | Pyridoxamine 5'-phosphate oxidase | 1.4.3.5 | 0.440 | |
| 1dfo | PLG | Serine hydroxymethyltransferase | 2.1.2.1 | 0.440 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1kvs | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.440 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.440 | |
| 1rbz | KT5 | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.440 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.440 | |
| 2cnt | COA | Ribosomal-protein-alanine acetyltransferase | / | 0.440 | |
| 2egl | SAH | Diphthine synthase | / | 0.440 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.440 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2v6g | NAP | 3-oxo-Delta(4,5)-steroid 5-beta-reductase | / | 0.440 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 3cin | NAD | Myo-inositol-1-phosphate synthase-related protein | / | 0.440 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.440 | |
| 3ge6 | FMN | Nitroreductase | / | 0.440 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.440 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3q8h | AO9 | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase | / | 0.440 | |
| 3r6s | CMP | CRP-like cAMP-activated global transcriptional regulator | / | 0.440 | |
| 3v9y | 24L | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.440 | |
| 4f6w | 0SS | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.440 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.440 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE26 | / | 0.440 | |
| 4x28 | FDA | Acyl-CoA dehydrogenase FadE27 | / | 0.440 | |
| 5eja | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.440 |