sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4g8c | C6L | Alpha/beta hydrolase fold protein |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4g8c | C6L | Alpha/beta hydrolase fold protein | / | 1.000 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.531 | |
| 4g8b | HL6 | Alpha/beta hydrolase fold protein | / | 0.526 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.511 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.508 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.504 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.504 | |
| 3ipq | 965 | Oxysterols receptor LXR-alpha | / | 0.503 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.503 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.501 | |
| 2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.501 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.500 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.498 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.497 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.496 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.496 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.494 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.492 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.491 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.491 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.490 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.490 | |
| 1pq6 | 965 | Oxysterols receptor LXR-beta | / | 0.489 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.488 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.488 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.488 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.486 | |
| 4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.486 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.485 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.485 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.485 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.484 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.484 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.483 | |
| 3fzn | D7K | Benzoylformate decarboxylase | 4.1.1.7 | 0.482 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.481 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.481 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.481 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.481 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.480 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.479 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.479 | |
| 3wd9 | QPC | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.479 | |
| 4iae | 1DX | Alr2278 protein | / | 0.479 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.479 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.478 | |
| 1zdw | FLV | Prenyltransferase | / | 0.478 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.478 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.477 | |
| 1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.476 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.476 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.475 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.475 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.474 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.474 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.474 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.474 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.474 | |
| 1dr4 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.473 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.473 | |
| 3b9l | AZZ | Serum albumin | / | 0.473 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.473 | |
| 3zia | ADP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.473 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.472 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.472 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.472 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.472 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.471 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.471 | |
| 2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.471 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.470 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.470 | |
| 3g4l | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 4c1i | EH9 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.470 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.470 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.470 | |
| 1el4 | CTZ | Obelin | / | 0.469 | |
| 1ro9 | 8BR | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.469 | |
| 1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.469 | |
| 2in6 | 839 | Wee1-like protein kinase | 2.7.10.2 | 0.469 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.469 | |
| 4s1i | PLP | Pyridoxal kinase, putative | / | 0.469 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.469 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.468 | |
| 2vq7 | NAP | Putative flavin-containing monooxygenase | / | 0.468 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.468 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 4jlj | 1NM | Deoxycytidine kinase | 2.7.1.74 | 0.468 | |
| 4kp6 | 1S1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.468 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.467 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.467 | |
| 4cav | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.467 | |
| 2qw8 | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.466 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.466 | |
| 4oew | 5IO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.466 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.466 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.465 | |
| 2reh | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.465 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.465 | |
| 3bi6 | 396 | Wee1-like protein kinase | 2.7.10.2 | 0.465 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.464 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.464 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
| 4mv1 | ADP | Biotin carboxylase | 6.3.4.14 | 0.464 | |
| 5uvi | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 4dk7 | 0KS | Oxysterols receptor LXR-beta | / | 0.463 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.462 | |
| 1x8b | 824 | Wee1-like protein kinase | 2.7.10.2 | 0.462 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 2iya | ZIO | Oleandomycin glycosyltransferase | / | 0.462 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.462 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3o9l | LPN | Renin | 3.4.23.15 | 0.462 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.462 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.462 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.462 | |
| 1s36 | CEI | Obelin | / | 0.461 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.461 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.461 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.461 | |
| 3gts | D3M | DdmC | / | 0.461 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.461 | |
| 3nxy | D2H | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3s3v | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.461 | |
| 3w1w | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.461 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.461 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.461 | |
| 1pl6 | 572 | Sorbitol dehydrogenase | 1.1.1.14 | 0.460 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.460 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 3arv | SAU | Chitinase A | / | 0.460 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.460 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.460 | |
| 4n3r | 2GU | Tankyrase-1 | 2.4.2.30 | 0.460 | |
| 1h69 | ARH | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.459 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.459 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.459 | |
| 3imx | B84 | Glucokinase | 2.7.1.2 | 0.459 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.459 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.459 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.458 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.458 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.458 | |
| 3p5s | AVU | CD38 molecule | / | 0.458 | |
| 3prf | FP3 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.458 | |
| 3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.458 | |
| 4euf | NAD | Trans-2-enoyl-CoA reductase [NADH] | / | 0.458 | |
| 1zeo | C01 | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 2g0g | SP0 | Peroxisome proliferator-activated receptor gamma | / | 0.457 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.457 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.457 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.457 | |
| 3szf | DCQ | Sulfide-quinone reductase | / | 0.457 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.457 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.457 | |
| 4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.457 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.456 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.456 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.456 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.456 | |
| 2r86 | ATP | 5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase | / | 0.456 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.456 | |
| 3d73 | NBB | Pheromone-binding protein ASP1 | / | 0.456 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.456 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.456 | |
| 3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 3sl8 | JN7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.456 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.456 | |
| 4imu | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.456 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.456 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1e7a | PFL | Serum albumin | / | 0.455 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.455 | |
| 1xds | DRA | Aclacinomycin 10-hydroxylase RdmB | 4.1.1 | 0.455 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.455 | |
| 2xvv | 9DN | Serum albumin | / | 0.455 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 3h4v | DVP | Pteridine reductase 1 | 1.5.1.33 | 0.455 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3oag | LPQ | Renin | 3.4.23.15 | 0.455 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.455 | |
| 3q2m | CKI | Spectinomycin phosphotransferase | / | 0.455 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1dr3 | HBI | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.454 | |
| 2fb8 | 215 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.454 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.454 | |
| 3owx | XRA | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.454 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.454 | |
| 3u8d | U8D | Phospholipase A2, membrane associated | / | 0.454 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.454 | |
| 4gr9 | 372 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.454 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.454 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.454 | |
| 1pd8 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.453 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.453 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.453 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.453 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.453 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.453 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.453 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.452 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2e99 | B08 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.452 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.452 | |
| 2mm3 | CHO | Gastrotropin | / | 0.452 | |
| 2vd0 | D27 | Hematopoietic prostaglandin D synthase | / | 0.452 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.452 | |
| 3akm | 11D | Fatty acid-binding protein, intestinal | / | 0.452 | |
| 3t8x | T8X | T-cell surface glycoprotein CD1b | / | 0.452 | |
| 4bfy | ZVY | Pantothenate kinase | 2.7.1.33 | 0.452 | |
| 4kq6 | DLZ | 6,7-dimethyl-8-ribityllumazine synthase | / | 0.452 | |
| 5bn4 | ANP | V-type ATP synthase alpha chain | / | 0.452 | |
| 1kmv | LII | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.451 | |
| 1osv | CHC | Bile acid receptor | / | 0.451 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.451 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.451 | |
| 2g27 | 4LG | Renin | 3.4.23.15 | 0.451 | |
| 2gpj | FAD | Siderophore-interacting protein | / | 0.451 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 3biz | 61E | Wee1-like protein kinase | 2.7.10.2 | 0.451 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.451 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.451 | |
| 4jsi | Q05 | Nitric oxide synthase, brain | 1.14.13.39 | 0.451 | |
| 5mht | SAH | Modification methylase HhaI | 2.1.1.37 | 0.451 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.451 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.450 | |
| 1qjg | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.450 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.450 | |
| 3hfb | ML4 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.450 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.450 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 3vmm | P0D | Alanine--anticapsin ligase | / | 0.450 | |
| 4boe | CLR | Japanin | / | 0.450 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.450 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.450 | |
| 5kp2 | COA | 3-oxoacyl-[acyl-carrier-protein] synthase 3 protein 2 | / | 0.450 | |
| 1hfr | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.449 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.449 | |
| 2zb4 | 5OP | Prostaglandin reductase 2 | 1.3.1.48 | 0.449 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.449 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.449 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.449 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.449 | |
| 1rkp | IBM | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.448 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.448 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.448 | |
| 2uyh | SAH | Modification methylase HhaI | 2.1.1.37 | 0.448 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 3gam | MXX | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.448 | |
| 3gjw | GJW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.448 | |
| 4b66 | NAP | L-ornithine N(5)-monooxygenase | / | 0.448 | |
| 4bvn | P32 | Beta-1 adrenergic receptor | / | 0.448 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.448 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.448 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.448 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.448 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.448 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.448 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.447 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.447 | |
| 1sjw | NGV | Nogalonic acid methyl ester cyclase | / | 0.447 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.447 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 2a3b | CFF | Endochitinase B1 | 3.2.1.14 | 0.447 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.447 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.447 | |
| 3dge | ADP | Sensor histidine kinase | / | 0.447 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3nj0 | PYV | Abscisic acid receptor PYL2 | / | 0.447 | |
| 3nn6 | HNK | 6-hydroxy-L-nicotine oxidase | / | 0.447 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.447 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.447 | |
| 3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.447 | |
| 4cax | MYA | Glycylpeptide N-tetradecanoyltransferase | 2.3.1.97 | 0.447 | |
| 4gts | 7TP | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.447 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.447 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 1kms | LIH | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1rzu | ADP | Glycogen synthase 1 | 2.4.1.21 | 0.446 | |
| 1ygk | RRC | Pyridoxal kinase | 2.7.1.35 | 0.446 | |
| 2esd | NAP | NADP-dependent glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.9 | 0.446 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.446 | |
| 2vtd | LKM | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.446 | |
| 2x9v | TMQ | Pteridine reductase | / | 0.446 | |
| 2z7g | EH9 | Adenosine deaminase | 3.5.4.4 | 0.446 | |
| 3akz | GSU | Glutamate--tRNA ligase 2 | / | 0.446 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4ejn | 0R4 | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.446 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.446 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.446 | |
| 1eji | THF | Serine hydroxymethyltransferase, cytosolic | / | 0.445 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.445 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.445 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.445 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 2ejz | SAH | Diphthine synthase | / | 0.445 | |
| 2f98 | NGV | Aklanonic acid methyl ester cyclase AcmA | 5.5.1.23 | 0.445 | |
| 2i9k | SAH | Modification methylase HhaI | 2.1.1.37 | 0.445 | |
| 2jfh | LK1 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.445 | |
| 2zi5 | 3L1 | Deoxycytidine kinase | 2.7.1.74 | 0.445 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.445 | |
| 3hyw | DCQ | Sulfide-quinone reductase | / | 0.445 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.445 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.445 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.445 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.445 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.445 | |
| 5d5b | CAU | Beta-2 adrenergic receptor | / | 0.445 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.444 | |
| 1mxt | FAE | Cholesterol oxidase | 1.1.3.6 | 0.444 | |
| 1tw2 | ERT | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.444 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.444 | |
| 1ve3 | SAM | Uncharacterized protein | / | 0.444 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.444 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2zs9 | ADP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 3hu1 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.444 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.443 | |
| 1i05 | LTL | Major urinary protein 6 | / | 0.443 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.443 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.443 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.443 | |
| 1xuo | LA1 | Integrin alpha-L | / | 0.443 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.443 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.443 | |
| 3bl7 | DD1 | m7GpppX diphosphatase | 3.6.1.59 | 0.443 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3eku | CY9 | Actin-5C | / | 0.443 | |
| 3gi2 | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3hcr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.443 | |
| 3hf8 | ML0 | Tryptophan 5-hydroxylase 1 | 1.14.16.4 | 0.443 | |
| 4at3 | LTI | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.443 | |
| 4gtt | 7TQ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 4lrr | CF9 | Thymidylate synthase | / | 0.443 | |
| 4wh2 | ADP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.443 | |
| 5k2d | ZMA | Adenosine receptor A2a | / | 0.443 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1enp | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.442 | |
| 1gt5 | BZQ | Odorant-binding protein | / | 0.442 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.442 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.442 | |
| 2b04 | CHO | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.442 | |
| 2bkt | RPF | Renin | 3.4.23.15 | 0.442 | |
| 2bpo | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 2d06 | EST | Sulfotransferase 1A1 | 2.8.2.1 | 0.442 | |
| 2gqg | 1N1 | Tyrosine-protein kinase ABL1 | 2.7.10.2 | 0.442 | |
| 2pl0 | STI | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 2w3m | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3a78 | 3EV | Vitamin D3 receptor | / | 0.442 | |
| 3d76 | NBB | Pheromone-binding protein ASP1 | / | 0.442 | |
| 3dh7 | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.442 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 4k38 | SAM | Anaerobic sulfatase-maturating enzyme | 1.8.98 | 0.442 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.442 | |
| 4zzj | CNA | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.442 | |
| 5iu8 | 6DZ | Adenosine receptor A2a | / | 0.442 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.442 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.441 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.441 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.441 | |
| 2a9z | 26A | Adenosine kinase | 2.7.1.20 | 0.441 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 2oz5 | 7XY | Uncharacterized protein | / | 0.441 | |
| 3g6z | A7T | Renin | 3.4.23.15 | 0.441 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.441 | |
| 3irn | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.441 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.441 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.441 | |
| 4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.441 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.440 | |
| 1q13 | TES | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.440 | |
| 2a1t | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.440 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 2gpv | OHT | Estrogen-related receptor gamma | / | 0.440 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.440 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.440 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 2xls | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 3cr0 | 809 | Wee1-like protein kinase | 2.7.10.2 | 0.440 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.440 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3l3m | A92 | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.440 | |
| 3sgv | 2BJ | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.440 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4at5 | MUJ | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.440 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.440 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.440 |