sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.699 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.689 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.689 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.686 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.683 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.679 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.677 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.676 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.675 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.675 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.673 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.672 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.670 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.667 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.666 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.664 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.662 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.661 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.655 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.654 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.646 | |
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.645 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.642 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.638 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.634 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.633 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.633 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.631 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.626 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.624 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.624 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.622 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.618 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.618 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.613 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.610 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.609 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.603 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.597 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.593 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.578 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.577 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.563 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.560 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.544 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.532 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.530 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.529 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.527 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.524 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.519 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.517 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.513 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.508 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.506 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.504 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.504 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.497 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.494 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.493 | |
| 2nnh | REA | Cytochrome P450 2C8 | / | 0.492 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.490 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.489 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.484 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.483 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.478 | |
| 3wec | AUI | Cytochrome P450 | / | 0.478 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.477 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.476 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.476 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.475 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.475 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.473 | |
| 1m13 | HYF | Nuclear receptor subfamily 1 group I member 2 | / | 0.469 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.469 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.468 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.466 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.466 | |
| 3s79 | ASD | Aromatase | 1.14.14.14 | 0.464 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.461 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.461 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.461 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.461 | |
| 2y3s | TIR | TamL | / | 0.460 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.460 | |
| 4b7d | QLE | Cytochrome P450 monooxygenase PikC | / | 0.459 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.458 | |
| 3lu8 | IQX | Serum albumin | / | 0.457 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.457 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.453 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.453 | |
| 3cv9 | VDX | Vitamin D3 dihydroxylase | / | 0.452 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.451 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.450 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.450 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.450 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.448 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.447 | |
| 2y4g | TIR | TamL | / | 0.447 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.447 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.447 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.446 | |
| 2y3r | TRK | TamL | / | 0.446 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.445 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.444 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.443 | |
| 3qlr | QLR | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 4ia1 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.443 | |
| 4ktl | 1CQ | Cytochrome P450 | / | 0.443 | |
| 2y3r | TIR | TamL | / | 0.442 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.442 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.441 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.441 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 3th8 | TH9 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.440 | |
| 4dvq | 1CA | Cytochrome P450 11B2, mitochondrial | 1.14.15.4 | 0.440 |