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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.25

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.251.000
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.580
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.493
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.492
3gubGUBDeath-associated protein kinase 12.7.11.10.490
3l8p0CEAngiopoietin-1 receptor2.7.10.10.484
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.482
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.482
3zsi52PMitogen-activated protein kinase 14/0.476
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.476
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.475
3gu83GUDeath-associated protein kinase 12.7.11.10.475
2c475IDCasein kinase I isoform gamma-2/0.474
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.474
1aq1STUCyclin-dependent kinase 22.7.11.220.473
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.473
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.472
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.468
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.468
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.468
2znnS44Peroxisome proliferator-activated receptor alpha/0.467
4wsqKSAAP2-associated protein kinase 12.7.11.10.467
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.466
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.464
2hog710Serine/threonine-protein kinase Chk12.7.11.10.463
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.463
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.463
3w33W19Epidermal growth factor receptor2.7.10.10.462
4gk2L66Ephrin type-A receptor 32.7.10.10.462
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.462
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.461
1bygSTUTyrosine-protein kinase CSK/0.460
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.460
4jia1K3Tyrosine-protein kinase JAK2/0.460
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.459
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.459
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.459
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.459
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.458
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.458
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.458
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.458
1k6cMK1Gag-Pol polyprotein3.4.23.160.457
2excJNKMitogen-activated protein kinase 102.7.11.240.457
2pvnP63Casein kinase II subunit alpha2.7.11.10.457
3pqbVGPPutative oxidoreductase/0.457
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.457
2hcdBIVVitamin D3 receptor A/0.456
2xviFADPutative flavin-containing monooxygenase/0.456
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.456
3poz03PEpidermal growth factor receptor2.7.10.10.456
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.456
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.455
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.455
2q59240Peroxisome proliferator-activated receptor gamma/0.455
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.455
4ia2BIVVitamin D3 receptor A/0.455
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.455
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.455
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.454
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.454
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.454
4hvi19STyrosine-protein kinase JAK32.7.10.20.454
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.454
2h96893Mitogen-activated protein kinase 82.7.11.240.453
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.453
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.453
1sn5T3Transthyretin/0.452
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.452
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.452
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.452
4r20AERCytochrome P450 family 17 polypeptide 2/0.452
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.451
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.451
4c62XWWTyrosine-protein kinase JAK2/0.451
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.451
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.451
5e8wSTUTGF-beta receptor type-12.7.11.300.451
1pkdUCNCyclin-dependent kinase 22.7.11.220.450
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.450
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.450
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.449
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.449
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.449
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.449
3ttjJBIMitogen-activated protein kinase 102.7.11.240.449
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.449
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.449
5e8xSTUTGF-beta receptor type-12.7.11.300.449
1jioDEB6-deoxyerythronolide B hydroxylase/0.448
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.448
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.448
3hx4ANPCalmodulin-domain protein kinase 1/0.448
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4jqeANPCasein kinase II subunit alpha2.7.11.10.448
4l9kEHFSerum albumin/0.448
1vjy460TGF-beta receptor type-12.7.11.300.447
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.447
2dvlFADAcyl-CoA dehydrogenase/0.447
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.447
3gc9B45Mitogen-activated protein kinase 112.7.11.240.447
3jynNDPQuinone oxidoreductase/0.447
3uyt0CKCasein kinase I isoform delta2.7.11.10.447
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.447
4ia7BIVVitamin D3 receptor A/0.447
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.446
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.446
2xa4AZ5Tyrosine-protein kinase JAK2/0.446
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.446
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.446
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.446
4hvh19RTyrosine-protein kinase JAK32.7.10.20.446
5dp2NAPCurF/0.446
1k6pXN3Gag-Pol polyprotein3.4.23.160.445
1kkq471Peroxisome proliferator-activated receptor alpha/0.445
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.445
3w32W32Epidermal growth factor receptor2.7.10.10.445
4bcqTJFCyclin-dependent kinase 22.7.11.220.445
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.445
4gk4L90Ephrin type-A receptor 32.7.10.10.445
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.444
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.444
2yekEAMBromodomain-containing protein 2/0.444
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.444
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.444
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.444
4loqSB4Mitogen-activated protein kinase 14/0.444
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1y0s331Peroxisome proliferator-activated receptor delta/0.443
3dxjNE6DNA-directed RNA polymerase subunit beta/0.443
3dxjNE6DNA-directed RNA polymerase subunit beta'/0.443
3eb0DRKUncharacterized protein/0.443
4ia3BIVVitamin D3 receptor A/0.443
1di8DTQCyclin-dependent kinase 22.7.11.220.442
1pjkANPCasein kinase II subunit alpha2.7.11.10.442
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.442
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.442
3ogqAB1Pol polyprotein/0.442
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.442
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.442
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.441
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.441
3ormAGSSerine/threonine protein kinase/0.441
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
3tmz06XCytochrome P450 2B41.14.14.10.441
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.441
4btkDTQTau-tubulin kinase 12.7.11.10.441
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.441
4ia1BIVVitamin D3 receptor A/0.441
4jboWPHAurora kinase A2.7.11.10.441
4kb81QNCasein kinase I isoform delta2.7.11.10.441
4yuqKS1Calmodulin-like domain protein kinase/0.441
2wotZZGTGF-beta receptor type-12.7.11.300.440
3hllI45Mitogen-activated protein kinase 14/0.440
3mdvCL6Cholesterol 24-hydroxylase/0.440
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.440
4fob0USALK tyrosine kinase receptor2.7.10.10.440
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4nfn2KCTau-tubulin kinase 12.7.11.10.440
4qmpDKISerine/threonine-protein kinase 242.7.11.10.440