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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.11.000
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.681
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.473
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.469
3ctj320Hepatocyte growth factor receptor2.7.10.10.468
3iw8HIZMitogen-activated protein kinase 14/0.464
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.454
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.454
4plpNADHomospermidine synthase2.5.1.440.450
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.448
3dl9V2HVitamin D 25-hydroxylase/0.446
1mp0NADAlcohol dehydrogenase class-31.1.1.10.445
1tj0FADBifunctional protein PutA1.5.5.20.445
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.445
4ih8B43Calmodulin-domain protein kinase 1/0.443
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
4nka2K7Fibroblast growth factor receptor 1/0.441
4tvbNADHomospermidine synthase2.5.1.440.441
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.440