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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fv6E57Mitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fv6E57Mitogen-activated protein kinase 12.7.11.241.000
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.608
3i60E86Mitogen-activated protein kinase 12.7.11.240.600
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.550
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.516
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.499
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.488
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.486
4qnyANPMitogen activated protein kinase, putative/0.485
4nifANPMitogen-activated protein kinase 12.7.11.240.472
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.469
4h3qANPMitogen-activated protein kinase 12.7.11.240.468
2yaaATPDeath-associated protein kinase 2/0.463
4eooATPCyclin-dependent kinase 22.7.11.220.461
4i5cC5ITyrosine-protein kinase JAK1/0.458
4e6d0NUTyrosine-protein kinase JAK2/0.453
5dnrATPAurora kinase A2.7.11.10.453
1qmzATPCyclin-dependent kinase 22.7.11.220.451
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.450
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.447
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.447
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
5dosATPAurora kinase A2.7.11.10.446
2ojj82AMitogen-activated protein kinase 12.7.11.240.445
3gu7ADPDeath-associated protein kinase 12.7.11.10.445
3lltANPProtein serine/threonine kinase-1/0.444
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.444
4deeADPAurora kinase A2.7.11.10.444
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.444
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.441
4btjADPTau-tubulin kinase 12.7.11.10.441