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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fv0EK3Mitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fv0EK3Mitogen-activated protein kinase 12.7.11.241.000
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.602
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.590
4fv4EK7Mitogen-activated protein kinase 12.7.11.240.535
4i22IREEpidermal growth factor receptor2.7.10.10.522
3qyw6PBMitogen-activated protein kinase 12.7.11.240.516
4fv9E71Mitogen-activated protein kinase 12.7.11.240.514
2oji33AMitogen-activated protein kinase 12.7.11.240.510
4bcoT6QCyclin-dependent kinase 22.7.11.220.505
4fmqANPMitogen-activated protein kinase 12.7.11.240.504
4fuxE75Mitogen-activated protein kinase 12.7.11.240.503
4kbk1QGCasein kinase I isoform delta2.7.11.10.503
2c3iIYZSerine/threonine-protein kinase pim-12.7.11.10.501
4g6oE28Mitogen-activated protein kinase 12.7.11.240.498
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.498
2z7lS91Mitogen-activated protein kinase 12.7.11.240.497
4aacAAVMitogen-activated protein kinase 14/0.496
4lopSB4Mitogen-activated protein kinase 14/0.495
4b99R4LMitogen-activated protein kinase 72.7.11.240.493
3uvqFS8Mitogen-activated protein kinase 14/0.492
2izrBRKCasein kinase I isoform gamma-32.7.11.10.491
1tvoFRZMitogen-activated protein kinase 12.7.11.240.490
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.490
1jpaANPEphrin type-B receptor 22.7.10.10.489
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.489
4kb81QNCasein kinase I isoform delta2.7.11.10.489
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.488
2xp2VGHALK tyrosine kinase receptor2.7.10.10.488
4kiq1RAMitogen-activated protein kinase 14/0.488
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.486
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.486
4gt3ATPMitogen-activated protein kinase 12.7.11.240.486
4s34ANPMitogen-activated protein kinase 12.7.11.240.486
2qo9ANPEphrin type-A receptor 32.7.10.10.485
4c4jX21Dual specificity protein kinase TTK2.7.12.10.485
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.485
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.484
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.484
3sa0NRAMitogen-activated protein kinase 12.7.11.240.483
4bcqTJFCyclin-dependent kinase 22.7.11.220.483
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.482
4fob0USALK tyrosine kinase receptor2.7.10.10.481
4kba1QMCasein kinase I isoform delta2.7.11.10.481
4riyADPEpidermal growth factor receptor2.7.10.10.481
1bygSTUTyrosine-protein kinase CSK/0.480
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.480
2izsBRQCasein kinase I isoform gamma-32.7.11.10.480
2vu3LZECyclin-dependent kinase 22.7.11.220.480
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.479
4erkOLOMitogen-activated protein kinase 12.7.11.240.479
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.478
3uyt0CKCasein kinase I isoform delta2.7.11.10.478
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.478
4hjoAQ4Epidermal growth factor receptor2.7.10.10.478
4loqSB4Mitogen-activated protein kinase 14/0.478
4yuqKS1Calmodulin-like domain protein kinase/0.478
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.477
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.476
3ormAGSSerine/threonine protein kinase/0.476
4fv7E94Mitogen-activated protein kinase 12.7.11.240.476
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.475
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.475
4anqVGHALK tyrosine kinase receptor2.7.10.10.475
2gs7ANPEpidermal growth factor receptor2.7.10.10.474
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.474
1k6vXN2Gag-Pol polyprotein3.4.23.160.473
2ojj82AMitogen-activated protein kinase 12.7.11.240.473
2p33J07Mitogen-activated protein kinase 102.7.11.240.473
2xvdAS6Ephrin type-B receptor 42.7.10.10.473
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.473
3gc9B45Mitogen-activated protein kinase 112.7.11.240.473
3gubGUBDeath-associated protein kinase 12.7.11.10.473
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
3k5uPFQAurora kinase A2.7.11.10.472
2w1fL0FAurora kinase A2.7.11.10.471
3fi3JK2Mitogen-activated protein kinase 102.7.11.240.471
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.471
5e8xSTUTGF-beta receptor type-12.7.11.300.471
1ywrLI9Mitogen-activated protein kinase 14/0.470
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.470
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.470
3mdvCL6Cholesterol 24-hydroxylase/0.470
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.470
3w551FMMitogen-activated protein kinase 12.7.11.240.470
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.470
1pmn984Mitogen-activated protein kinase 102.7.11.240.469
2vx07X7Ephrin type-B receptor 42.7.10.10.469
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
4bcnT9NCyclin-dependent kinase 22.7.11.220.469
4jq8KJ8Epidermal growth factor receptor2.7.10.10.469
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.469
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.468
1unlRRCCyclin-dependent-like kinase 52.7.11.10.468
3fln3FNMitogen-activated protein kinase 14/0.468
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
3mtfA3FActivin receptor type-12.7.11.300.468
3r9dX6BCyclin-dependent kinase 22.7.11.220.468
3rm618ZCyclin-dependent kinase 22.7.11.220.468
3s4qNK0Mitogen-activated protein kinase 14/0.468
3wecAUICytochrome P450/0.468
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.468
4bb432WEphrin type-B receptor 42.7.10.10.468
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.467
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.467
2r43G3GGag-Pol polyprotein3.4.23.160.467
2y9qANPMitogen-activated protein kinase 12.7.11.240.467
3lfnA27Cyclin-dependent kinase 22.7.11.220.467
4aa5NQBMitogen-activated protein kinase 14/0.467
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.467
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.466
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.466
4gk3L87Ephrin type-A receptor 32.7.10.10.466
1kv2B96Mitogen-activated protein kinase 14/0.465
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.465
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.465
2x9fX9FEphrin type-B receptor 42.7.10.10.465
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.465
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.465
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.465
3r83Z14Cyclin-dependent kinase 22.7.11.220.465
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.465
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.465
2q61SF1Peroxisome proliferator-activated receptor gamma/0.464
2w05FRTCyclin-dependent kinase 22.7.11.220.464
3cylVITBasic phospholipase A2 homolog piratoxin-2/0.464
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.464
3raiX85Cyclin-dependent kinase 22.7.11.220.464
3t113T1Gag-Pol polyprotein3.4.23.160.464
3ttjJBIMitogen-activated protein kinase 102.7.11.240.464
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.464
4g170VNCasein kinase I isoform gamma-32.7.11.10.464
1k6cMK1Gag-Pol polyprotein3.4.23.160.463
1xjdSTUProtein kinase C theta type2.7.11.130.463
2b55D31Cyclin-dependent kinase 22.7.11.220.463
2balPQAMitogen-activated protein kinase 14/0.463
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.463
2itqITQEpidermal growth factor receptor2.7.10.10.463
3ddqRRCCyclin-dependent kinase 22.7.11.220.463
3gggNADPrephenate dehydrogenase/0.463
3hl7I47Mitogen-activated protein kinase 14/0.463
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.463
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.463
4c4iX20Dual specificity protein kinase TTK2.7.12.10.463
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.463
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.463
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.463
1pkdUCNCyclin-dependent kinase 22.7.11.220.462
1xl2189Gag-Pol polyprotein3.4.23.160.462
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.462
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.462
2np8CC3Aurora kinase A2.7.11.10.462
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.462
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.462
3t8oATPRhodopsin kinase/0.462
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.462
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.462
4hnf16WCasein kinase I isoform delta2.7.11.10.462
1oi9N20Cyclin-dependent kinase 22.7.11.220.461
1u54ACPActivated CDC42 kinase 1/0.461
2c475IDCasein kinase I isoform gamma-2/0.461
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.461
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.461
3nwq2NCGag-Pol polyprotein3.4.23.160.461
3ocgOCGMitogen-activated protein kinase 14/0.461
3pvuQRWBeta-adrenergic receptor kinase 12.7.11.150.461
3r8vZ62Cyclin-dependent kinase 22.7.11.220.461
3uimANPBRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 12.7.10.10.461
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.461
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.461
4n0sDHCMitogen-activated protein kinase 12.7.11.240.461
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.461
2acxANPG protein-coupled receptor kinase 62.7.11.160.460
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.460
2itnANPEpidermal growth factor receptor2.7.10.10.460
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.460
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.460
3vthAPCCarbamoyltransferase/0.460
4fod0UVALK tyrosine kinase receptor2.7.10.10.460
4oaeCLMUncharacterized protein/0.460
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.459
1u4dDBQActivated CDC42 kinase 1/0.459
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.459
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.459
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.459
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.459
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.459
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.459
3zewSTUEphrin type-B receptor 42.7.10.10.459
4aa4QC0Mitogen-activated protein kinase 14/0.459
4fz60VGTyrosine-protein kinase SYK2.7.10.20.459
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.459
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.459
4nifANPMitogen-activated protein kinase 12.7.11.240.459
5e8wSTUTGF-beta receptor type-12.7.11.300.459
1w8cN69Cyclin-dependent kinase 22.7.11.220.458
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.458
2btsU32Cyclin-dependent kinase 22.7.11.220.458
2iw94SPCyclin-dependent kinase 22.7.11.220.458
2vwy7X5Ephrin type-B receptor 42.7.10.10.458
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.458
3cgfJNFMitogen-activated protein kinase 102.7.11.240.458
3h0sB38Acetyl-CoA carboxylase/0.458
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.458
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.458
3tmz06XCytochrome P450 2B41.14.14.10.458
4cfnJYMCyclin-dependent kinase 22.7.11.220.458
4jr3KJREpidermal growth factor receptor2.7.10.10.458
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.458
4s32ANPMitogen-activated protein kinase 12.7.11.240.458
1e1xNW1Cyclin-dependent kinase 22.7.11.220.457
1h1r6CPCyclin-dependent kinase 22.7.11.220.457
2h96893Mitogen-activated protein kinase 82.7.11.240.457
2hog710Serine/threonine-protein kinase Chk12.7.11.10.457
2uzeC95Cyclin-dependent kinase 22.7.11.220.457
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.457
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.457
3w18N13Aurora kinase A2.7.11.10.457
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4g1wG1WMitogen-activated protein kinase 82.7.11.240.457
4hee14RPeroxisome proliferator-activated receptor gamma/0.457
4hgt15GCasein kinase I isoform delta2.7.11.10.457
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.457
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.457
1oiyN41Cyclin-dependent kinase 22.7.11.220.456
2b1pAIZMitogen-activated protein kinase 102.7.11.240.456
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.456
2xikJ60Serine/threonine-protein kinase 252.7.11.10.456
3hx4ANPCalmodulin-domain protein kinase 1/0.456
3pvwQRXBeta-adrenergic receptor kinase 12.7.11.150.456
3tdvGDPGentamicin resistance protein/0.456
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.456
4a4vYFDPeroxisome proliferator-activated receptor gamma/0.456
4cy8FDA2-hydroxybiphenyl-3-monooxygenase/0.456
4g160VMCasein kinase I isoform gamma-32.7.11.10.456
4qmwKS1Serine/threonine-protein kinase 242.7.11.10.456
5dgzL20Serine/threonine-protein kinase pim-12.7.11.10.456
1oiuN76Cyclin-dependent kinase 22.7.11.220.455
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.455
2gekGDPPhosphatidyl-myo-inositol mannosyltransferase2.4.1.570.455
2of2547Tyrosine-protein kinase Lck2.7.10.20.455
2vn0TDZCytochrome P450 2C8/0.455
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.455
3eljGS7Mitogen-activated protein kinase 82.7.11.240.455
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.455
3le62BZCyclin-dependent kinase 22.7.11.220.455
3mpaSB2Mitogen-activated protein kinase 14/0.455
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.455
4g2fC07Ephrin type-A receptor 32.7.10.10.455
4gk2L66Ephrin type-A receptor 32.7.10.10.455
4ix6ADPUncharacterized protein/0.455
4nb6444Nuclear receptor ROR-gamma/0.455
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
2etm7PYFocal adhesion kinase 12.7.10.20.454
2i4jDRJPeroxisome proliferator-activated receptor gamma/0.454
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.454
3icsCOACoenzyme A disulfide reductase/0.454
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.454
3s2pPMUCyclin-dependent kinase 22.7.11.220.454
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.454
4b0gVEKAurora kinase A2.7.11.10.454
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.454
4c4g7RODual specificity protein kinase TTK2.7.12.10.454
4iebANPCalmodulin-domain protein kinase 1/0.454
4jayFADUDP-N-acetylenolpyruvoylglucosamine reductase/0.454
1eh4IC1Casein kinase I homolog 12.7.11.10.453
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.453
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.453
2chz093Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
2excJNKMitogen-activated protein kinase 102.7.11.240.453
2f2cAP9Cyclin-dependent kinase 62.7.11.220.453
2jn3JN3Fatty acid-binding protein, liver/0.453
2wotZZGTGF-beta receptor type-12.7.11.300.453
2znnS44Peroxisome proliferator-activated receptor alpha/0.453
3nbwTR4Ketohexokinase/0.453
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.453
4mbl26LSerine/threonine-protein kinase pim-12.7.11.10.453
4s33ANPMitogen-activated protein kinase 12.7.11.240.453
1k6tXN1Gag-Pol polyprotein3.4.23.160.452
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.452
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.452
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.452
2c3qGTXGlutathione S-transferase theta-12.5.1.180.452
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.452
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.452
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.452
3ddpRC8Cyclin-dependent kinase 22.7.11.220.452
3nwyGTPUridylate kinase/0.452
3oriAGSSerine/threonine protein kinase/0.452
3uvp048Mitogen-activated protein kinase 14/0.452
3w33W19Epidermal growth factor receptor2.7.10.10.452
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.452
4bdbODOSerine/threonine-protein kinase Chk22.7.11.10.452
4c3rACPAurora kinase A2.7.11.10.452
4c58824Cyclin-G-associated kinase2.7.11.10.452
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.452
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.452
4jqeANPCasein kinase II subunit alpha2.7.11.10.452
4xldBRLPeroxisome proliferator-activated receptor gamma/0.452
5c7oNADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific1.2.1.120.452
1k6pXN3Gag-Pol polyprotein3.4.23.160.451
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.451
1os1ATPPhosphoenolpyruvate carboxykinase (ATP)/0.451
1v0pPVBCell division control protein 2 homolog2.7.11.220.451
1zarADPRIO-type serine/threonine-protein kinase Rio22.7.11.10.451
2a4lRRCCyclin-dependent kinase 22.7.11.220.451
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.451
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.451
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.451
2xb7GUIALK tyrosine kinase receptor2.7.10.10.451
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.451
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.451
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.451
4bb3KKAIsopenicillin N synthase1.21.3.10.451
4enhFVXCholesterol 24-hydroxylase/0.451
4id71G0Activated CDC42 kinase 1/0.451
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.451
4oavACP2-5A-dependent ribonuclease3.1.260.451
4wkqIREEpidermal growth factor receptor2.7.10.10.451
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
4yutFMNFamily 3 adenylate cyclase/0.451
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.451
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.450
2c4g514Cyclin-dependent kinase 22.7.11.220.450
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.450
3bgzVX3Serine/threonine-protein kinase pim-12.7.11.10.450
3dogNNNCyclin-dependent kinase 22.7.11.220.450
3ogqAB1Pol polyprotein/0.450
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.450
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.450
3vs3VSETyrosine-protein kinase HCK2.7.10.20.450
3w32W32Epidermal growth factor receptor2.7.10.10.450
4bcmT7ZCyclin-dependent kinase 22.7.11.220.450
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.450
4c62XWWTyrosine-protein kinase JAK2/0.450
4dtk7LISerine/threonine-protein kinase pim-12.7.11.10.450
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.450
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.450
4hgs15GCasein kinase I isoform gamma-32.7.11.10.450
4jboWPHAurora kinase A2.7.11.10.450
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.450
1di8DTQCyclin-dependent kinase 22.7.11.220.449
2bfyH1NAurora kinase B-A2.7.11.10.449
2qa2FADPolyketide oxygenase CabE/0.449
2qocANPEphrin type-A receptor 32.7.10.10.449
2vwz7X6Ephrin type-B receptor 42.7.10.10.449
3kf7L9GMitogen-activated protein kinase 14/0.449
3mvl38PMitogen-activated protein kinase 14/0.449
3nwxKVSGag-Pol polyprotein3.4.23.160.449
3qqlX03Cyclin-dependent kinase 22.7.11.220.449
3wfjNAD2-dehydropantoate 2-reductase/0.449
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.449
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.449
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.449
4kin1M8Mitogen-activated protein kinase 14/0.449
5dr9SKEAurora kinase A2.7.11.10.449
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.448
1ee0CAA2-pyrone synthase/0.448
1fvt106Cyclin-dependent kinase 22.7.11.220.448
1gqtACPRibokinase/0.448
1ie4T44Transthyretin/0.448
2dv7SAHDiphthine synthase/0.448
2ghmLICMitogen-activated protein kinase 14/0.448
2hw2RFPRifampin ADP-ribosyl transferase/0.448
2iw84SPCyclin-dependent kinase 22.7.11.220.448
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.448
2vwu7X1Ephrin type-B receptor 42.7.10.10.448
2vwx7X4Ephrin type-B receptor 42.7.10.10.448
2y6o1N1Ephrin type-A receptor 42.7.10.10.448
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.448
3oom507Activin receptor type-12.7.11.300.448
3oroAGSSerine/threonine protein kinase/0.448
3rkb12ZCyclin-dependent kinase 22.7.11.220.448
4asf62UATP-dependent molecular chaperone HSP82/0.448
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.448
4fyn0VETyrosine-protein kinase SYK2.7.10.20.448
4i231C9Epidermal growth factor receptor2.7.10.10.448
1h1s4SPCyclin-dependent kinase 22.7.11.220.447
1hvhQ82Gag-Pol polyprotein3.4.23.160.447
1u8fNADGlyceraldehyde-3-phosphate dehydrogenase1.2.1.120.447
1wvxBD4Death-associated protein kinase 12.7.11.10.447
2cchATPCyclin-dependent kinase 22.7.11.220.447
2gtk208Peroxisome proliferator-activated receptor gamma/0.447
2j0k4STFocal adhesion kinase 12.7.10.20.447
2j7t274Serine/threonine-protein kinase 102.7.11.10.447
2q5g1FAPeroxisome proliferator-activated receptor delta/0.447
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.447
2y4gTIRTamL/0.447
2yfeYFEPeroxisome proliferator-activated receptor gamma/0.447
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.447
3fmkFMKMitogen-activated protein kinase 14/0.447
3pe6ZYHMonoglyceride lipase/0.447
3qrtX14Cyclin-dependent kinase 22.7.11.220.447
3qwkX62Cyclin-dependent kinase 22.7.11.220.447
3vjoANPEpidermal growth factor receptor2.7.10.10.447
4gub0Y4Casein kinase II subunit alpha2.7.11.10.447
4hys1BJMitogen-activated protein kinase 82.7.11.240.447
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.447
4ix5ANPUncharacterized protein/0.447
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.447
5awmANPStress-activated protein kinase JNK2.7.11.240.447
5c8wPCGcGMP-dependent protein kinase 22.7.11.120.447
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1lsoNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.446
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.446
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.446
2j0dERYCytochrome P450 3A4/0.446
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.446
2om9AJAPeroxisome proliferator-activated receptor gamma/0.446
2q59240Peroxisome proliferator-activated receptor gamma/0.446
2vrx447Aurora kinase B-A2.7.11.10.446
3c50ADPRhodopsin kinase/0.446
3cs8BRLPeroxisome proliferator-activated receptor gamma/0.446
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.446
3gbuATPUncharacterized sugar kinase PH14592.7.10.446
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.446
3nbvANPKetohexokinase/0.446
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.446
3sheI85MAP kinase-activated protein kinase 32.7.11.10.446
4eok4SPCyclin-dependent kinase 22.7.11.220.446
4ez50RSCyclin-dependent kinase 62.7.11.220.446
4ful0VUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4gk4L90Ephrin type-A receptor 32.7.10.10.446
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.446
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.446
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.446
4y95746Tyrosine-protein kinase/0.446
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
5dt3ATPAurora kinase A2.7.11.10.446
1bdlIM1Gag-Pol polyprotein3.4.23.160.445
1ol7ADPAurora kinase A2.7.11.10.445
1phhFADp-hydroxybenzoate hydroxylase/0.445
1wvgAPRCDP-glucose 4,6-dehydratase4.2.1.450.445
1wvySTUDeath-associated protein kinase 12.7.11.10.445
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.445
2py3ACPFibroblast growth factor receptor 2/0.445
2pzpACPFibroblast growth factor receptor 2/0.445
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.445
2vd5BI8Myotonin-protein kinase2.7.11.10.445
2x1nX1NCyclin-dependent kinase 22.7.11.220.445
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.445
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.445
3l8p0CEAngiopoietin-1 receptor2.7.10.10.445
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.445
3qx4X4BCyclin-dependent kinase 22.7.11.220.445
3r1qX75Cyclin-dependent kinase 22.7.11.220.445
3r9hZ67Cyclin-dependent kinase 22.7.11.220.445
3sp6IL2Peroxisome proliferator-activated receptor alpha/0.445
3ttiKBIMitogen-activated protein kinase 102.7.11.240.445
3w9rA8SAbscisic acid receptor PYL9/0.445
4b12NHWGlycylpeptide N-tetradecanoyltransferase/0.445
4bqpVMYEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
4c4h7RODual specificity protein kinase TTK2.7.12.10.445
4h3qANPMitogen-activated protein kinase 12.7.11.240.445
4o0uADNAurora kinase A2.7.11.10.445
5dr2ATPAurora kinase A2.7.11.10.445
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.444
1vyw292Cyclin-dependent kinase 22.7.11.220.444
1y0s331Peroxisome proliferator-activated receptor delta/0.444
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.444
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.444
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.444
2p4yC03Peroxisome proliferator-activated receptor gamma/0.444
2q5p241Peroxisome proliferator-activated receptor gamma/0.444
2qo7ANPEphrin type-A receptor 32.7.10.10.444
3bheBZNGag-Pol polyprotein3.4.23.160.444
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.444
3dxjNE6DNA-directed RNA polymerase subunit beta/0.444
3dxjNE6DNA-directed RNA polymerase subunit beta'/0.444
3hllI45Mitogen-activated protein kinase 14/0.444
3ig7EFPCyclin-dependent kinase 22.7.11.220.444
3kgaLX9MAP kinase-activated protein kinase 22.7.11.10.444
3qtzX42Cyclin-dependent kinase 22.7.11.220.444
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.444
3vt8YI3Vitamin D3 receptor/0.444
3zh8C58Protein kinase C iota type2.7.11.130.444
4fv8E63Mitogen-activated protein kinase 12.7.11.240.444
4h8nNDPNADPH-dependent conjugated polyketone reductase C2/0.444
4jbqVX6Aurora kinase A2.7.11.10.444
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.444
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.444
4nr42LKCREB-binding protein/0.444
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
5aaaVGHALK tyrosine kinase receptor2.7.10.10.444
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
5eypLOCTubulin beta chain/0.444
1aq1STUCyclin-dependent kinase 22.7.11.220.443
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.443
1ie9VDXVitamin D3 receptor/0.443
2dsiSAHDiphthine synthase/0.443
2j0m4STFocal adhesion kinase 12.7.10.20.443
2vxoXMPGMP synthase [glutamine-hydrolyzing]6.3.5.20.443
2zjwREFCasein kinase II subunit alpha2.7.11.10.443
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.443
3d1xROCGag-Pol polyprotein3.4.23.160.443
3hmm855TGF-beta receptor type-12.7.11.300.443
3mqe416Prostaglandin G/H synthase 21.14.99.10.443
3q9xEMOCasein kinase II subunit alpha2.7.11.10.443
3sqq99ZCyclin-dependent kinase 22.7.11.220.443
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.443
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.443
4e5yNDPGDP-L-fucose synthase1.1.1.2710.443
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.443
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
5eoxADPType 4 fimbrial biogenesis protein PilM/0.443
1ouk084Mitogen-activated protein kinase 14/0.442
1pjkANPCasein kinase II subunit alpha2.7.11.10.442
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.442
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.442
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.442
2v7a627Tyrosine-protein kinase ABL12.7.10.20.442
2vgoAD5Aurora kinase B-A2.7.11.10.442
2x7gPVBSRSF protein kinase 22.7.11.10.442
3emg685Tyrosine-protein kinase SYK2.7.10.20.442
3kpkFADSulfide-quinone reductase/0.442
3q92XNBKetohexokinase/0.442
3qa2XNAKetohexokinase/0.442
3qaiXNNKetohexokinase/0.442
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.442
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.442
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.442
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.442
4ia2BIVVitamin D3 receptor A/0.442
4nks2M2Fibroblast growth factor receptor 1/0.442
5ap57RODual specificity protein kinase TTK2.7.12.10.442
1zrzBI1Protein kinase C iota type2.7.11.130.441
2duv371Cyclin-dependent kinase 22.7.11.220.441
2dwbANPAurora kinase A2.7.11.10.441
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.441
2hk51BMTyrosine-protein kinase HCK2.7.10.20.441
2i40BLZCyclin-dependent kinase 22.7.11.220.441
2o2u738Mitogen-activated protein kinase 102.7.11.240.441
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.441
2yfxVGHALK tyrosine kinase receptor2.7.10.10.441
2zdt46CMitogen-activated protein kinase 102.7.11.240.441
3cgoJNOMitogen-activated protein kinase 102.7.11.240.441
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.441
3flzFLZMitogen-activated protein kinase 14/0.441
3gxlQIGTGF-beta receptor type-12.7.11.300.441
3h9f92MDual specificity protein kinase TTK2.7.12.10.441
3nww3NWMitogen-activated protein kinase 14/0.441
3oquA8SAbscisic acid receptor PYL9/0.441
3qu0X40Cyclin-dependent kinase 22.7.11.220.441
3w0oADPHygromycin-B 4-O-kinase2.7.1.1630.441
4ewn0VRImidazole glycerol phosphate synthase subunit HisF4.1.30.441
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.441
4hge15VTyrosine-protein kinase JAK2/0.441
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.441
4q72FADBifunctional protein PutA/0.441
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
5cvhADPCasein kinase II subunit alpha2.7.11.10.441
5drdATPAurora kinase A2.7.11.10.441
5dt4ATPAurora kinase A2.7.11.10.441
1bl6SB6Mitogen-activated protein kinase 14/0.440
1ckpPVBCyclin-dependent kinase 22.7.11.220.440
1osvCHCBile acid receptor/0.440
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.440
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.440
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.440
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.440
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.440
3efwAK8Aurora kinase A2.7.11.10.440
3fklFKLMitogen-activated protein kinase 14/0.440
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.440
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.440
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.440
3qx2X63Cyclin-dependent kinase 22.7.11.220.440
3r7yZ04Cyclin-dependent kinase 22.7.11.220.440
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.440
3tqhNDPQuinone oxidoreductase/0.440
3u4uLNHCasein kinase II subunit alpha2.7.11.10.440
3vf9477Tyrosine-protein kinase SYK2.7.10.20.440
3wmxNADNAD dependent epimerase/dehydratase/0.440
3zep1NXTyrosine-protein kinase JAK32.7.10.20.440
4aotGW8Serine/threonine-protein kinase 102.7.11.10.440
4bcpT3CCyclin-dependent kinase 22.7.11.220.440
4c02TAKActivin receptor type-12.7.11.300.440
4grb0XGCasein kinase II subunit alpha2.7.11.10.440
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.440
4nk92K5Fibroblast growth factor receptor 1/0.440
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.440
4qmpDKISerine/threonine-protein kinase 242.7.11.10.440
4zseANPEpidermal growth factor receptor2.7.10.10.440
5uviZMAAdenosine receptor A2a/0.440