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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fr4STUSerine/threonine-protein kinase 32A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fr4STUSerine/threonine-protein kinase 32A2.7.11.11.000
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.487
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.485
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.480
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.477
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.471
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.470
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.470
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.470
2hog710Serine/threonine-protein kinase Chk12.7.11.10.469
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.468
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.467
3zh8C58Protein kinase C iota type2.7.11.130.467
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.466
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.466
4fv9E71Mitogen-activated protein kinase 12.7.11.240.464
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.462
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.461
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.460
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.458
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.458
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.458
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.456
2j0m4STFocal adhesion kinase 12.7.10.20.455
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.455
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.455
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.455
1pkdUCNCyclin-dependent kinase 22.7.11.220.454
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.454
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.453
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.450
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.450
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.450
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.447
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.445
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.444
3a62STURibosomal protein S6 kinase beta-12.7.11.10.444
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
1fvv107Cyclin-dependent kinase 22.7.11.220.443
2in6839Wee1-like protein kinase2.7.10.20.443
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.443
3i60E86Mitogen-activated protein kinase 12.7.11.240.443
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.443
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.443
4riyADPEpidermal growth factor receptor2.7.10.10.443
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.442
1bygSTUTyrosine-protein kinase CSK/0.440
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.440
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.440
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.440
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.440