Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fps0UXQueuine tRNA-ribosyltransferase2.4.2.29

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fps0UXQueuine tRNA-ribosyltransferase2.4.2.291.000
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.792
4gkt0O1Queuine tRNA-ribosyltransferase2.4.2.290.744
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.716
3sm0AEKQueuine tRNA-ribosyltransferase2.4.2.290.682
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.678
4gg90WWQueuine tRNA-ribosyltransferase2.4.2.290.660
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.648
1y5wNEZQueuine tRNA-ribosyltransferase2.4.2.290.636
3gc4AAQQueuine tRNA-ribosyltransferase2.4.2.290.626
1q63AIQQueuine tRNA-ribosyltransferase2.4.2.290.625
4fsa0V3Queuine tRNA-ribosyltransferase2.4.2.290.605
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.599
4fr10V2Queuine tRNA-ribosyltransferase2.4.2.290.593
4giy0WYQueuine tRNA-ribosyltransferase2.4.2.290.577
1y5vNE8Queuine tRNA-ribosyltransferase2.4.2.290.565
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.559
4q8pCKRQueuine tRNA-ribosyltransferase2.4.2.290.555
1k4hAPQQueuine tRNA-ribosyltransferase2.4.2.290.544
2z1wBDIQueuine tRNA-ribosyltransferase2.4.2.290.542
1q65BHBQueuine tRNA-ribosyltransferase2.4.2.290.541
2qzrS79Queuine tRNA-ribosyltransferase2.4.2.290.539
2z1xPRFQueuine tRNA-ribosyltransferase2.4.2.290.534
3gc52MQQueuine tRNA-ribosyltransferase2.4.2.290.521
4gcxPRFQueuine tRNA-ribosyltransferase2.4.2.290.515
2bbf344Queuine tRNA-ribosyltransferase2.4.2.290.513
1f3eDPZQueuine tRNA-ribosyltransferase2.4.2.290.504
1ozqPRFQueuine tRNA-ribosyltransferase2.4.2.290.496
1q66KMBQueuine tRNA-ribosyltransferase2.4.2.290.493
4g95OAGDihydrofolate reductase1.5.1.30.489
1n2vBDIQueuine tRNA-ribosyltransferase2.4.2.290.486
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.485
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.484
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.482
1t1sCBQ1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.479
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.477
3oafOAGDihydrofolate reductase1.5.1.30.476
1p0ePRFQueuine tRNA-ribosyltransferase2.4.2.290.475
1ygjRMCPyridoxal kinase2.7.1.350.474
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.473
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.472
2oalFADFlavin-dependent tryptophan halogenase RebH1.14.19.90.472
1efzPRFQueuine tRNA-ribosyltransferase2.4.2.290.471
2j0sANPEukaryotic initiation factor 4A-III3.6.4.130.471
1nqvLMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.468
4hvxQEIQueuine tRNA-ribosyltransferase2.4.2.290.468
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.466
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.466
4fgcPQ0NADPH-dependent 7-cyano-7-deazaguanine reductase1.7.1.130.466
2isc223Purine nucleoside phosphorylase, putative/0.465
1ve3SAMUncharacterized protein/0.464
2eerNADNAD-dependent alcohol dehydrogenase1.1.1.10.464
3zeiAWHO-acetylserine sulfhydrylase/0.464
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.463
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.463
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.462
4hshQEIQueuine tRNA-ribosyltransferase2.4.2.290.462
1r5yDQUQueuine tRNA-ribosyltransferase2.4.2.290.461
2cleF6FTryptophan synthase alpha chain/0.461
4kfj1R0Dihydrofolate reductase1.5.1.30.461
1mc5AHEAlcohol dehydrogenase class-31.1.1.10.459
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
1q4wDQUQueuine tRNA-ribosyltransferase2.4.2.290.459
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.459
3qttANPPantothenate synthetase/0.459
4dan2FAPurine nucleoside phosphorylase DeoD-type2.4.2.10.459
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.459
4z9rNADOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.459
1kruIPTGalactoside O-acetyltransferase2.3.1.180.457
3p9kSAHCaffeic acid O-methyltransferase/0.457
4lwaQ13Nitric oxide synthase oxygenase1.14.13.1650.457
3b7dCNIGlutamate receptor 2/0.455
3p9tTCLRepressor/0.455
3aw9GDUNAD-dependent epimerase/dehydratase/0.454
3cow52HPantothenate synthetase6.3.2.10.454
3g5sFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.454
3nyaJTZBeta-2 adrenergic receptor/0.454
1hbvGANGag-Pol polyprotein/0.453
3hf6LX0Tryptophan 5-hydroxylase 11.14.16.40.453
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.452
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.452
2pidYSATyrosine--tRNA ligase, mitochondrial6.1.1.10.452
3uzaT4GAdenosine receptor A2a/0.452
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.451
2w3aTOPDihydrofolate reductase1.5.1.30.451
3pm0BHFCytochrome P450 1B1/0.451
3tdaPN0Cytochrome P450 2D6/0.451
4qjcIXEDihydrofolate reductase1.5.1.30.451
4x81MVIMycinamicin III 3''-O-methyltransferase2.1.1.2370.451
3sn6P0GBeta-2 adrenergic receptor/0.451
1ivsVAAValine--tRNA ligase6.1.1.90.450
1x31FMNSubunit alpha of sarocosine oxidase/0.449
1x31FMNSubunit beta of sarcosine oxidase/0.449
2e48FADD-amino-acid oxidase1.4.3.30.449
2xauADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP433.6.4.130.449
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.449
3nxvD2FDihydrofolate reductase1.5.1.30.449
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.449
4y6gF6FTryptophan synthase alpha chain/0.449
5c1mCLRMu-type opioid receptor/0.449
1kyzFERCaffeic acid 3-O-methyltransferase2.1.1.680.448
2ojg19AMitogen-activated protein kinase 12.7.11.240.448
3pdqKC6Lysine-specific demethylase 4A1.14.110.448
4ddrMMVDihydrofolate reductase1.5.1.30.448
4dphP65Bifunctional dihydrofolate reductase-thymidylate synthase/0.448
3bllBPQQueuine tRNA-ribosyltransferase2.4.2.290.447
3hziATPSerine/threonine-protein kinase toxin HipA/0.447
3nxoD2BDihydrofolate reductase1.5.1.30.447
3s6aANPAdenosine monophosphate-protein transferase NmFic2.7.7.n10.447
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.447
4gmgNAPYersiniabactin biosynthetic protein YbtU/0.447
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.447
3uzcT4EAdenosine receptor A2a/0.447
1qxlFR8Adenosine deaminase3.5.4.40.446
1qzzSAMAclacinomycin 10-hydroxylase RdmB4.1.10.446
3nxyD2HDihydrofolate reductase1.5.1.30.446
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.446
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.446
3zj0ACOPutative acetyltransferase OgpAT/0.445
4jpe1M7Beta-secretase 13.4.23.460.445
5dbjFADFADH2-dependent halogenase PltA/0.445
5kwvANPPantothenate synthetase/0.445
1uk1FRQPoly [ADP-ribose] polymerase 12.4.2.300.444
2gd2CAAProbable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.444
2ydoADNAdenosine receptor A2a/0.444
3n1t5GPPurine nucleoside phosphoramidase/0.444
3sglSAMtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.444
3vri1KXHLA class I histocompatibility antigen, B-57 alpha chain/0.444
4lc71WPBeta-secretase 13.4.23.460.444
1hv9UD1Bifunctional protein GlmU/0.443
1ne6SP1cAMP-dependent protein kinase type I-alpha regulatory subunit/0.443
3cquCQURAC-alpha serine/threonine-protein kinase2.7.11.10.443
3ivxFG6Pantothenate synthetase6.3.2.10.443
3nxrD2DDihydrofolate reductase1.5.1.30.443
3rg9WRABifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3vv8B02Beta-secretase 13.4.23.460.443
5ab7MLCNonspecific lipid-transfer protein, putative/0.443
1gaxVAAValine--tRNA ligase6.1.1.90.442
1l0cCOTSerotonin N-acetyltransferase/0.442
1w7h3IPMitogen-activated protein kinase 14/0.442
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.442
3ar612DSarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.442
3c1xCKKHepatocyte growth factor receptor2.7.10.10.442
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.442
3t4eNADQuinate/shikimate dehydrogenase/0.442
3ts1TYATyrosine--tRNA ligase6.1.1.10.442
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.441
1owmFADDeoxyribodipyrimidine photo-lyase4.1.99.30.441
3n87N873-dehydroquinate dehydratase4.2.1.100.441
3udj092Beta-secretase 13.4.23.460.441
4da8BG2Purine nucleoside phosphorylase DeoD-type2.4.2.10.441
4i8vBHFCytochrome P450 1A11.14.14.10.441
1p44GEQEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
1pke2FDPurine nucleoside phosphorylase DeoD-type/0.440
1ygkRRCPyridoxal kinase2.7.1.350.440
3hfbML4Tryptophan 5-hydroxylase 11.14.16.40.440
3uawADNPurine nucleoside phosphorylase DeoD-type/0.440
3uxe465Ribosyldihydronicotinamide dehydrogenase [quinone]/0.440
4h3f10OBeta-secretase 13.4.23.460.440
4mm9FVXNa(+):neurotransmitter symporter (Snf family)/0.440
4q4eBB2Aminopeptidase N3.4.11.20.440
4req5ADMethylmalonyl-CoA mutase large subunit5.4.99.20.440
4x7zZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.440