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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fogC2FThymidylate synthase ThyA

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fogC2FThymidylate synthase ThyA/1.000
3bhlTHGThymidylate synthase/0.570
3bhrTHGThymidylate synthase/0.553
3bgxMEFThymidylate synthase/0.551
4isk1JYThymidylate synthase/0.547
2ftoCB3Thymidylate synthase/0.545
4knzCB3Thymidylate synthase/0.536
1an5CB3Thymidylate synthase/0.535
4gevCB3Thymidylate synthase/0.535
1tduCB3Thymidylate synthase/0.529
1dduCB3Thymidylate synthase/0.526
1tysDHFThymidylate synthase/0.517
1f4fTP3Thymidylate synthase/0.512
2vf0F89Thymidylate synthase/0.511
1fwmCB3Thymidylate synthase/0.505
4o7uTHFThymidylate synthase/0.504
1tlcF89Thymidylate synthase/0.503
4ez8DHFThymidylate synthase2.1.1.450.501
1f4gTP4Thymidylate synthase/0.497