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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fob0USALK tyrosine kinase receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fob0USALK tyrosine kinase receptor2.7.10.11.000
4fod0UVALK tyrosine kinase receptor2.7.10.10.604
4foc0UUALK tyrosine kinase receptor2.7.10.10.568
4cd0AWJALK tyrosine kinase receptor2.7.10.10.548
2xp2VGHALK tyrosine kinase receptor2.7.10.10.540
2yfxVGHALK tyrosine kinase receptor2.7.10.10.525
5aacVGHALK tyrosine kinase receptor2.7.10.10.523
2xa4AZ5Tyrosine-protein kinase JAK2/0.520
5aaaVGHALK tyrosine kinase receptor2.7.10.10.520
4nk92K5Fibroblast growth factor receptor 1/0.518
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.517
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.517
2itnANPEpidermal growth factor receptor2.7.10.10.513
4jia1K3Tyrosine-protein kinase JAK2/0.513
2xb7GUIALK tyrosine kinase receptor2.7.10.10.510
4anqVGHALK tyrosine kinase receptor2.7.10.10.507
5e8xSTUTGF-beta receptor type-12.7.11.300.505
2j0m4STFocal adhesion kinase 12.7.10.20.498
4nks2M2Fibroblast growth factor receptor 1/0.498
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.496
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.496
2itqITQEpidermal growth factor receptor2.7.10.10.495
3t8oATPRhodopsin kinase/0.495
4ansVGHALK tyrosine kinase receptor2.7.10.10.495
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.493
4b99R4LMitogen-activated protein kinase 72.7.11.240.491
4ccbOFGALK tyrosine kinase receptor2.7.10.10.491
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.491
1bygSTUTyrosine-protein kinase CSK/0.490
2bfyH1NAurora kinase B-A2.7.11.10.490
3pxkPXKFocal adhesion kinase 12.7.10.20.489
4y93746Tyrosine-protein kinase/0.489
4i22IREEpidermal growth factor receptor2.7.10.10.488
3a7hATPSerine/threonine-protein kinase 242.7.11.10.487
4fnzNZFALK tyrosine kinase receptor2.7.10.10.487
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.486
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.486
2qo9ANPEphrin type-A receptor 32.7.10.10.485
2ijmATPFocal adhesion kinase 12.7.10.20.484
5aabVGHALK tyrosine kinase receptor2.7.10.10.484
2ittAEEEpidermal growth factor receptor2.7.10.10.483
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.483
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.482
2j0lANPFocal adhesion kinase 12.7.10.20.481
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.481
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.480
2vgoAD5Aurora kinase B-A2.7.11.10.479
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.479
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.478
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.477
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.476
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.476
3w2sW2REpidermal growth factor receptor2.7.10.10.475
4c62XWWTyrosine-protein kinase JAK2/0.475
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.474
4gmy0X5Tyrosine-protein kinase JAK2/0.474
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.474
2itzIREEpidermal growth factor receptor2.7.10.10.473
2pwlACPFibroblast growth factor receptor 2/0.473
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.473
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.473
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.472
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.471
3a62STURibosomal protein S6 kinase beta-12.7.11.10.471
3gubGUBDeath-associated protein kinase 12.7.11.10.471
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.471
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.471
4g1wG1WMitogen-activated protein kinase 82.7.11.240.471
4gk3L87Ephrin type-A receptor 32.7.10.10.471
4id71G0Activated CDC42 kinase 1/0.471
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.470
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.470
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.470
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.470
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.470
4j95ACPFibroblast growth factor receptor 2/0.470
2hk51BMTyrosine-protein kinase HCK2.7.10.20.469
3lctADPALK tyrosine kinase receptor2.7.10.10.469
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.469
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.469
4qo9627Serine/threonine-protein kinase 242.7.11.10.469
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.468
2p33J07Mitogen-activated protein kinase 102.7.11.240.468
3emg685Tyrosine-protein kinase SYK2.7.10.20.468
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.467
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.466
2ituITQEpidermal growth factor receptor2.7.10.10.466
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.466
4jq8KJ8Epidermal growth factor receptor2.7.10.10.466
1aq1STUCyclin-dependent kinase 22.7.11.220.465
3zh8C58Protein kinase C iota type2.7.11.130.465
4jrvKJVEpidermal growth factor receptor2.7.10.10.465
5e8wSTUTGF-beta receptor type-12.7.11.300.465
3c4xATPRhodopsin kinase/0.464
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.464
4gk4L90Ephrin type-A receptor 32.7.10.10.464
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.463
2acxANPG protein-coupled receptor kinase 62.7.11.160.463
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.463
1pmn984Mitogen-activated protein kinase 102.7.11.240.462
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.462
3w33W19Epidermal growth factor receptor2.7.10.10.462
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.462
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.461
4j99ACPFibroblast growth factor receptor 2/0.461
4wboANWRhodopsin kinase/0.461
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.460
2pvnP63Casein kinase II subunit alpha2.7.11.10.460
2xvdAS6Ephrin type-B receptor 42.7.10.10.460
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.460
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.460
4riyADPEpidermal growth factor receptor2.7.10.10.460
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.459
3vjoANPEpidermal growth factor receptor2.7.10.10.459
4ic7ANPMitogen-activated protein kinase 72.7.11.240.459
4jboWPHAurora kinase A2.7.11.10.459
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.459
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.458
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.458
4f650S9Fibroblast growth factor receptor 1/0.458
4hvi19STyrosine-protein kinase JAK32.7.10.20.458
1u54ACPActivated CDC42 kinase 1/0.457
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.457
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.457
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.457
3l8p0CEAngiopoietin-1 receptor2.7.10.10.457
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.457
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.457
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.457
4qmtH1NSerine/threonine-protein kinase 242.7.11.10.457
5e8ySTUTGF-beta receptor type-22.7.11.300.457
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.456
2x1nX1NCyclin-dependent kinase 22.7.11.220.456
3le62BZCyclin-dependent kinase 22.7.11.220.456
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.455
2j0k4STFocal adhesion kinase 12.7.10.20.455
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.455
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.455
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.455
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.455
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.455
4dtaADNAPH(2'')-Id/0.455
4gk2L66Ephrin type-A receptor 32.7.10.10.455
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.454
2bujSTUSerine/threonine-protein kinase 16/0.454
2etm7PYFocal adhesion kinase 12.7.10.20.454
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.454
3k5uPFQAurora kinase A2.7.11.10.454
4l9i8PRRhodopsin kinase/0.454
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.454
4y95746Tyrosine-protein kinase/0.454
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.454
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.453
2itpAEEEpidermal growth factor receptor2.7.10.10.453
2vwu7X1Ephrin type-B receptor 42.7.10.10.453
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.453
4c57FEFCyclin-G-associated kinase2.7.11.10.453
4e730NRMitogen-activated protein kinase 82.7.11.240.453
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.453
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.452
3d7tSTUTyrosine-protein kinase CSK/0.451
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.451
4wkqIREEpidermal growth factor receptor2.7.10.10.451
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.450
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.450
4e93GUITyrosine-protein kinase Fes/Fps2.7.10.20.450
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.450
4erwSTUCyclin-dependent kinase 22.7.11.220.450
1m17AQ4Epidermal growth factor receptor2.7.10.10.449
4jqeANPCasein kinase II subunit alpha2.7.11.10.449
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.449
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.448
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.448
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.448
3js2VM1Fibroblast growth factor receptor 1/0.448
3rvg17PTyrosine-protein kinase JAK2/0.448
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.448
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.447
1pkdUCNCyclin-dependent kinase 22.7.11.220.447
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.447
2wxvWXVCyclin-dependent kinase 22.7.11.220.447
2zoq5IDMitogen-activated protein kinase 32.7.11.240.447
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.447
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.447
3ormAGSSerine/threonine protein kinase/0.447
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.447
3zewSTUEphrin type-B receptor 42.7.10.10.447
4g2fC07Ephrin type-A receptor 32.7.10.10.447
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.446
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.446
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.446
3du8553Glycogen synthase kinase-3 beta2.7.11.260.446
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.446
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.446
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.446
4ccuAWFALK tyrosine kinase receptor2.7.10.10.446
4qmlANPSerine/threonine-protein kinase 242.7.11.10.446
4yuqKS1Calmodulin-like domain protein kinase/0.446
5dr6SKEAurora kinase A2.7.11.10.446
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.445
3sheI85MAP kinase-activated protein kinase 32.7.11.10.445
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.445
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.445
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.445
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.444
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.444
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.444
2xyuQ9GEphrin type-A receptor 42.7.10.10.444
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.444
2yn8STUEphrin type-B receptor 42.7.10.10.444
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.444
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.444
3zmmF9JTyrosine-protein kinase JAK2/0.444
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.443
2ijmADPFocal adhesion kinase 12.7.10.20.443
2wihP48Cyclin-dependent kinase 22.7.11.220.443
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.443
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.443
4jq7KJQEpidermal growth factor receptor2.7.10.10.443
1h1s4SPCyclin-dependent kinase 22.7.11.220.442
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.442
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.442
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
2ydjYDJSerine/threonine-protein kinase Chk12.7.11.10.442
3cgoJNOMitogen-activated protein kinase 102.7.11.240.442
3qyw6PBMitogen-activated protein kinase 12.7.11.240.442
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.442
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.442
4b7sQLECytochrome P450 monooxygenase PikC/0.442
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.442
4f640S8Fibroblast growth factor receptor 1/0.442
4grb0XGCasein kinase II subunit alpha2.7.11.10.442
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
1rw8580TGF-beta receptor type-12.7.11.300.441
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.441
2of4979Tyrosine-protein kinase Lck2.7.10.20.441
3oroAGSSerine/threonine protein kinase/0.441
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.441
4aguD15Cyclin-dependent kinase-like 1/0.441
4enhFVXCholesterol 24-hydroxylase/0.441
1eh4IC1Casein kinase I homolog 12.7.11.10.440
2itwITQEpidermal growth factor receptor2.7.10.10.440
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.440
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.440
3bqr4RBDeath-associated protein kinase 3/0.440
4bbe3O4Tyrosine-protein kinase JAK2/0.440
4bcmT7ZCyclin-dependent kinase 22.7.11.220.440
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.440
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.440
4nka2K7Fibroblast growth factor receptor 1/0.440