Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4fnz | NZF | ALK tyrosine kinase receptor | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4fnz | NZF | ALK tyrosine kinase receptor | 2.7.10.1 | 1.000 | |
| 4dce | 0JF | ALK tyrosine kinase receptor | 2.7.10.1 | 0.644 | |
| 4fob | 0US | ALK tyrosine kinase receptor | 2.7.10.1 | 0.561 | |
| 3qlf | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.549 | |
| 3b2w | 9NH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.548 | |
| 3b8r | 887 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.528 | |
| 2itz | IRE | Epidermal growth factor receptor | 2.7.10.1 | 0.527 | |
| 4nks | 2M2 | Fibroblast growth factor receptor 1 | / | 0.522 | |
| 1xkk | FMM | Epidermal growth factor receptor | 2.7.10.1 | 0.514 | |
| 1m17 | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.508 | |
| 4nka | 2K7 | Fibroblast growth factor receptor 1 | / | 0.508 | |
| 4f64 | 0S8 | Fibroblast growth factor receptor 1 | / | 0.507 | |
| 2p2h | 994 | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.504 | |
| 4i23 | 1C9 | Epidermal growth factor receptor | 2.7.10.1 | 0.504 | |
| 2itt | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.502 | |
| 3js2 | VM1 | Fibroblast growth factor receptor 1 | / | 0.500 | |
| 3w33 | W19 | Epidermal growth factor receptor | 2.7.10.1 | 0.500 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.499 | |
| 2itp | AEE | Epidermal growth factor receptor | 2.7.10.1 | 0.496 | |
| 3c7q | XIN | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.496 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.492 | |
| 4c62 | XWW | Tyrosine-protein kinase JAK2 | / | 0.492 | |
| 2itn | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.491 | |
| 2ivu | ZD6 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.490 | |
| 3s4q | NK0 | Mitogen-activated protein kinase 14 | / | 0.490 | |
| 4k11 | 0J9 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.490 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.488 | |
| 4jrv | KJV | Epidermal growth factor receptor | 2.7.10.1 | 0.488 | |
| 4mxo | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.488 | |
| 2ath | 3EA | Peroxisome proliferator-activated receptor gamma | / | 0.487 | |
| 2c0i | L1G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.487 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.487 | |
| 1i7g | AZ2 | Peroxisome proliferator-activated receptor alpha | / | 0.486 | |
| 2fgi | PD1 | Fibroblast growth factor receptor 1 | / | 0.486 | |
| 3el8 | PD5 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.485 | |
| 4jr3 | KJR | Epidermal growth factor receptor | 2.7.10.1 | 0.485 | |
| 2c0t | L3G | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.484 | |
| 2xp2 | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.483 | |
| 3cjg | KIM | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.483 | |
| 2of2 | 547 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.482 | |
| 4hjo | AQ4 | Epidermal growth factor receptor | 2.7.10.1 | 0.482 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.481 | |
| 3kdu | NKS | Peroxisome proliferator-activated receptor alpha | / | 0.481 | |
| 3krw | BA1 | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.481 | |
| 2x8e | X8E | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.480 | |
| 4ftl | H0K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.480 | |
| 3bbt | FMM | Receptor tyrosine-protein kinase erbB-4 | 2.7.10.1 | 0.479 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.478 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.478 | |
| 2brn | DF1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.477 | |
| 4dfl | 0K0 | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.477 | |
| 4id7 | 1G0 | Activated CDC42 kinase 1 | / | 0.477 | |
| 1k7l | 544 | Peroxisome proliferator-activated receptor alpha | / | 0.476 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.476 | |
| 2itw | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.476 | |
| 5hes | 032 | Mitogen-activated protein kinase kinase kinase 20 | 2.7.11.25 | 0.476 | |
| 1qpd | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.475 | |
| 2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.475 | |
| 3eta | 351 | Insulin receptor | 2.7.10.1 | 0.475 | |
| 3poz | 03P | Epidermal growth factor receptor | 2.7.10.1 | 0.475 | |
| 3vrz | VRZ | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.475 | |
| 3vs6 | VSH | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.475 | |
| 4l7s | G7K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.475 | |
| 4mxx | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.475 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.474 | |
| 4ccb | OFG | ALK tyrosine kinase receptor | 2.7.10.1 | 0.474 | |
| 1y0s | 331 | Peroxisome proliferator-activated receptor delta | / | 0.473 | |
| 2xf0 | 4UB | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.473 | |
| 3lct | ADP | ALK tyrosine kinase receptor | 2.7.10.1 | 0.473 | |
| 4jq7 | KJQ | Epidermal growth factor receptor | 2.7.10.1 | 0.473 | |
| 1di9 | MSQ | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 1i7i | AZ2 | Peroxisome proliferator-activated receptor gamma | / | 0.472 | |
| 1zyj | BI5 | Mitogen-activated protein kinase 14 | / | 0.472 | |
| 2cdz | 23D | Serine/threonine-protein kinase PAK 4 | 2.7.11.1 | 0.472 | |
| 3q3b | 55E | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.472 | |
| 3qlg | 1N1 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.472 | |
| 3vjo | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.472 | |
| 3vs3 | VSE | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.472 | |
| 4fsz | HK8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.472 | |
| 4nk9 | 2K5 | Fibroblast growth factor receptor 1 | / | 0.472 | |
| 5aaa | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.471 | |
| 2eb3 | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.470 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.470 | |
| 4jq8 | KJ8 | Epidermal growth factor receptor | 2.7.10.1 | 0.470 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.470 | |
| 1y57 | MPZ | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.469 | |
| 2wmw | ZYW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.468 | |
| 2j5n | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.468 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.468 | |
| 4fsq | HK3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.468 | |
| 4ftm | 1HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.468 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.467 | |
| 4xld | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.467 | |
| 2ayp | 43A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.466 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.466 | |
| 4bdb | ODO | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.466 | |
| 2d4e | NAD | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] | / | 0.465 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.465 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.465 | |
| 4f63 | 0S7 | Fibroblast growth factor receptor 1 | / | 0.465 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.465 | |
| 1agw | SU2 | Fibroblast growth factor receptor 1 | / | 0.464 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.464 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 1fm6 | BRL | Peroxisome proliferator-activated receptor gamma | / | 0.463 | |
| 1u59 | STU | Tyrosine-protein kinase ZAP-70 | 2.7.10.2 | 0.463 | |
| 1yol | S03 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.463 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.463 | |
| 3mvl | 38P | Mitogen-activated protein kinase 14 | / | 0.463 | |
| 4cd0 | AWJ | ALK tyrosine kinase receptor | 2.7.10.1 | 0.463 | |
| 1rdt | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.462 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.461 | |
| 1osv | CHC | Bile acid receptor | / | 0.461 | |
| 2wmt | ZYT | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 2ym5 | YM5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.461 | |
| 2bdj | HET | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.460 | |
| 2wmx | ZY6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.460 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.460 | |
| 4oe2 | NAD | 2-aminomuconate 6-semialdehyde dehydrogenase | / | 0.460 | |
| 1kyo | SMA | Cytochrome b | / | 0.459 | |
| 2itu | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.459 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.459 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.459 | |
| 3tub | FPU | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.459 | |
| 4fic | 0UL | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.459 | |
| 4xli | 1N1 | Abelson tyrosine-protein kinase 2 | 2.7.10.2 | 0.459 | |
| 1fm9 | 570 | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 1nvr | STU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2hk5 | 1BM | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.458 | |
| 2vwx | 7X4 | Ephrin type-B receptor 4 | 2.7.10.1 | 0.458 | |
| 2wmu | ZYU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 2zno | S44 | Peroxisome proliferator-activated receptor gamma | / | 0.458 | |
| 3vs4 | VSF | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.458 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.458 | |
| 4fst | HK4 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 4ftk | H9K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.458 | |
| 4yzc | STU | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.458 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.457 | |
| 2r0u | M54 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 2zv9 | PP2 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.457 | |
| 3ac3 | KSH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.457 | |
| 3sp6 | IL2 | Peroxisome proliferator-activated receptor alpha | / | 0.457 | |
| 4bc6 | XZN | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.457 | |
| 4fc0 | 0T2 | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.457 | |
| 4h1m | 0YJ | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.457 | |
| 4i3v | NAD | Aldehyde dehydrogenase (NAD+) | / | 0.457 | |
| 4j97 | ACP | Fibroblast growth factor receptor 2 | / | 0.457 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.457 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.456 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 2xm9 | LWH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.456 | |
| 2ym7 | YM7 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 2zva | 1N1 | Tyrosine-protein kinase Lyn | 2.7.10.2 | 0.456 | |
| 3ac5 | KZM | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.456 | |
| 3fln | 3FN | Mitogen-activated protein kinase 14 | / | 0.456 | |
| 4fny | I3K | ALK tyrosine kinase receptor | 2.7.10.1 | 0.456 | |
| 4foc | 0UU | ALK tyrosine kinase receptor | 2.7.10.1 | 0.456 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.456 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.456 | |
| 5a3c | NAD | SIR2 family protein | / | 0.456 | |
| 1qpe | PP2 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.455 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2pzr | ACP | Fibroblast growth factor receptor 2 | / | 0.455 | |
| 2uze | C95 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.455 | |
| 2ym3 | YM3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 3gfe | P37 | Mitogen-activated protein kinase 14 | / | 0.455 | |
| 4an9 | 2P7 | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.455 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.455 | |
| 4fsw | HK6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 4kao | KAO | Focal adhesion kinase 1 | 2.7.10.2 | 0.455 | |
| 1rrm | APR | Lactaldehyde reductase | 1.1.1.77 | 0.454 | |
| 2br1 | PFP | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.454 | |
| 2zm1 | KSF | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.454 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.454 | |
| 3vs5 | VSG | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.454 | |
| 4gap | FAD | Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial | 1.6.5.9 | 0.454 | |
| 4lgh | 0JN | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.454 | |
| 5a3b | APR | SIR2 family protein | / | 0.454 | |
| 5hi2 | BAX | Serine/threonine-protein kinase B-raf | 2.7.11.1 | 0.454 | |
| 1bxs | NAD | Retinal dehydrogenase 1 | 1.2.1.36 | 0.453 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.453 | |
| 2yaa | ATP | Death-associated protein kinase 2 | / | 0.453 | |
| 3dmt | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.453 | |
| 4kiq | 1RA | Mitogen-activated protein kinase 14 | / | 0.453 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 3qcq | 3Q0 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.452 | |
| 3sgx | 0FW | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.452 | |
| 3v5l | 0G1 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.452 | |
| 4a0m | NAD | Betaine aldehyde dehydrogenase, chloroplastic | 1.2.1.8 | 0.452 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.452 | |
| 5e8x | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.452 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.451 | |
| 1okz | UCN | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.451 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.451 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 2ivv | PP1 | Proto-oncogene tyrosine-protein kinase receptor Ret | 2.7.10.1 | 0.451 | |
| 2rew | REW | Peroxisome proliferator-activated receptor alpha | / | 0.451 | |
| 3flw | FLW | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 3hng | 8ST | Vascular endothelial growth factor receptor 1 | 2.7.10.1 | 0.451 | |
| 3ocg | OCG | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4agw | NG7 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.451 | |
| 4f9m | FCM | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.451 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.450 | |
| 1nkz | RG1 | Light-harvesting protein B-800/850 alpha chain | / | 0.450 | |
| 1nkz | RG1 | Light-harvesting protein B-800/850 beta chain | / | 0.450 | |
| 3p4t | FAO | Putative acyl-CoA dehydrogenase | / | 0.450 | |
| 3vnt | 0JA | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.450 | |
| 4ftn | 2HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.450 | |
| 4hjf | C2E | GGDEF family protein | / | 0.450 | |
| 4ks7 | X4Z | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.450 | |
| 4xuh | SFI | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 1stc | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.449 | |
| 1znq | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.449 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.449 | |
| 2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.449 | |
| 2wms | ZYS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2wmv | ZYV | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2ycs | NXP | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.449 | |
| 3w2r | W2R | Epidermal growth factor receptor | 2.7.10.1 | 0.449 | |
| 4btk | DTQ | Tau-tubulin kinase 1 | 2.7.11.1 | 0.449 | |
| 4ih8 | B43 | Calmodulin-domain protein kinase 1 | / | 0.449 | |
| 4lgg | VGG | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.449 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.449 | |
| 4x4l | NAI | Retinal dehydrogenase 1 | 1.2.1.36 | 0.449 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.448 | |
| 1sm2 | STU | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.448 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.448 | |
| 2of4 | 979 | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.448 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.448 | |
| 2vd5 | BI8 | Myotonin-protein kinase | 2.7.11.1 | 0.448 | |
| 3ad6 | KSC | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.448 | |
| 3sz0 | FAD | Sulfide-quinone reductase | / | 0.448 | |
| 3t2y | FAD | Sulfide-quinone reductase | / | 0.448 | |
| 3vso | EK1 | Peroxisome proliferator-activated receptor gamma | / | 0.448 | |
| 3w0a | DS5 | Vitamin D3 receptor | / | 0.448 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.448 | |
| 4joa | 3DK | ALK tyrosine kinase receptor | 2.7.10.1 | 0.448 | |
| 4v37 | NAD | Betaine aldehyde dehydrogenase, chloroplastic | 1.2.1.8 | 0.448 | |
| 4wlo | NAI | Malate dehydrogenase, mitochondrial | 1.1.1.37 | 0.448 | |
| 4wq4 | ATP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.448 | |
| 5aac | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.448 | |
| 1rek | B8L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.447 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.447 | |
| 1zys | 199 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2ca0 | PXI | Cytochrome P450 monooxygenase PikC | / | 0.447 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 2pwl | ACP | Fibroblast growth factor receptor 2 | / | 0.447 | |
| 3mfr | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.447 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.447 | |
| 4fmq | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.447 | |
| 4ftc | H6K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 4gk3 | L87 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.447 | |
| 4mlh | VO2 | Glucokinase | 2.7.1.2 | 0.447 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.447 | |
| 4riy | ADP | Epidermal growth factor receptor | 2.7.10.1 | 0.447 | |
| 5aab | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.447 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 1ot7 | IU5 | Bile acid receptor | / | 0.446 | |
| 1uu8 | BI1 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.446 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.446 | |
| 2yn8 | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.446 | |
| 3ada | NAD | Subunit alpha of sarocosine oxidase | / | 0.446 | |
| 3mpt | 1GK | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3w18 | N13 | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 4aa4 | QC0 | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.446 | |
| 4mcv | 29K | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.446 | |
| 4qmn | DB8 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.446 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.445 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2q8s | L92 | Peroxisome proliferator-activated receptor gamma | / | 0.445 | |
| 3aox | EMH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.445 | |
| 3bhy | 7CP | Death-associated protein kinase 3 | / | 0.445 | |
| 3fsk | RO6 | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 4a06 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.445 | |
| 4ftj | H8K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 4mxy | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 4mxz | DB8 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 1pow | FAD | Pyruvate oxidase | 1.2.3.3 | 0.444 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3fr0 | AJB | Glucokinase | 2.7.1.2 | 0.444 | |
| 3tuc | FPW | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.444 | |
| 4an2 | EUI | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.444 | |
| 4bcq | TJF | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 4ftu | 7HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 1w84 | L12 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 1zmc | NAD | Dihydrolipoyl dehydrogenase, mitochondrial | 1.8.1.4 | 0.443 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.443 | |
| 2itv | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.443 | |
| 2xyu | Q9G | Ephrin type-A receptor 4 | 2.7.10.1 | 0.443 | |
| 2yfx | VGH | ALK tyrosine kinase receptor | 2.7.10.1 | 0.443 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 4erk | OLO | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.443 | |
| 4ft5 | H2K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 4hyi | 1AO | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2bi4 | NAD | Lactaldehyde reductase | 1.1.1.77 | 0.442 | |
| 2ok7 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.442 | |
| 3l8x | N4D | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 3pvu | QRW | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.442 | |
| 4b7x | NAP | Probable oxidoreductase | / | 0.442 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 4irn | FAD | AnaB | / | 0.442 | |
| 4l9y | 1VU | L-malyl-CoA/beta-methylmalyl-CoA lyase | 4.1.3.24 | 0.442 | |
| 1cx2 | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.441 | |
| 1ppj | SMA | Cytochrome b | / | 0.441 | |
| 2ieb | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2itx | ANP | Epidermal growth factor receptor | 2.7.10.1 | 0.441 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.441 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.441 | |
| 3nun | JMZ | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3okx | SAM | S-adenosyl-L-methionine-binding protein RPA0152 | / | 0.441 | |
| 3pp1 | IZG | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.441 | |
| 3q92 | XNB | Ketohexokinase | / | 0.441 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.441 | |
| 3vjh | J35 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 4eqc | XR1 | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.441 | |
| 4f4p | 0SB | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.441 | |
| 4fsm | HK1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4h1j | 0YH | Protein-tyrosine kinase 2-beta | 2.7.10.2 | 0.441 | |
| 4hvh | 19R | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.441 | |
| 4j4b | NAI | Uncharacterized protein | / | 0.441 | |
| 1bx6 | BA1 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 1yc2 | NAD | NAD-dependent protein deacylase 2 | / | 0.440 | |
| 2dub | CO8 | Enoyl-CoA hydratase, mitochondrial | 4.2.1.17 | 0.440 | |
| 2ie0 | ZID | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 2p5u | NAD | UDP-glucose 4-epimerase | / | 0.440 | |
| 2q0b | ACP | Fibroblast growth factor receptor 2 | / | 0.440 | |
| 2qhn | 582 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 3fi4 | FI4 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3pvw | QRX | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.440 | |
| 4a4v | YFD | Peroxisome proliferator-activated receptor gamma | / | 0.440 | |
| 4anb | YQY | Dual specificity mitogen-activated protein kinase kinase 1 | 2.7.12.2 | 0.440 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
| 4flh | 14K | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
| 4ftq | 4HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4ftr | 5HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.440 |