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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fnyI3KALK tyrosine kinase receptor2.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fnyI3KALK tyrosine kinase receptor2.7.10.11.000
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.510
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.496
3eta351Insulin receptor2.7.10.10.492
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.490
3tubFPUTyrosine-protein kinase SYK2.7.10.20.489
4tyj0LIFibroblast growth factor receptor 42.7.10.10.489
4uxq0LIFibroblast growth factor receptor 42.7.10.10.480
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.479
4i22IREEpidermal growth factor receptor2.7.10.10.479
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.470
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.467
4qrc0LIFibroblast growth factor receptor 42.7.10.10.464
3naxMP73-phosphoinositide-dependent protein kinase 12.7.11.10.462
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.461
3ce31FNHepatocyte growth factor receptor2.7.10.10.456
4hni16WCasein kinase I isoform epsilon2.7.11.10.455
4elb34RDihydrofolate reductase/0.454
3ctj320Hepatocyte growth factor receptor2.7.10.10.453
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.452
4o2z046Mitogen-activated protein kinase/0.451
4riyADPEpidermal growth factor receptor2.7.10.10.451
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.450
4kaoKAOFocal adhesion kinase 12.7.10.20.450
1xddAAYIntegrin alpha-L/0.448
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.447
2yac937Serine/threonine-protein kinase PLK12.7.11.210.446
4iarERM5-hydroxytryptamine receptor 1B/0.446
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.446
4eevL1XHepatocyte growth factor receptor2.7.10.10.445
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.445
4nka2K7Fibroblast growth factor receptor 1/0.443
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.442
4gmy0X5Tyrosine-protein kinase JAK2/0.442
3cth319Hepatocyte growth factor receptor2.7.10.10.441
3abaFLICytochrome P450/0.440