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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fl3ANPTyrosine-protein kinase SYK2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fl3ANPTyrosine-protein kinase SYK2.7.10.21.000
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.607
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.519
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.518
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.508
5cnnANPEpidermal growth factor receptor2.7.10.10.504
4lfiGNPCasein kinase II subunit alpha2.7.11.10.485
5cnoANPEpidermal growth factor receptor2.7.10.10.484
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.482
3vn9ANKDual specificity mitogen-activated protein kinase kinase 62.7.12.20.482
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.471
4qnyANPMitogen activated protein kinase, putative/0.470
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.465
3orpAGSSerine/threonine protein kinase/0.464
3plsANPMacrophage-stimulating protein receptor2.7.10.10.463
5dnrATPAurora kinase A2.7.11.10.463
3c4zADPRhodopsin kinase/0.460
3nieANPMitogen-activated protein kinase/0.458
4k33ACPFibroblast growth factor receptor 32.7.10.10.458
1jnkANPMitogen-activated protein kinase 102.7.11.240.454
4deeADPAurora kinase A2.7.11.10.454
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.451
1b38ATPCyclin-dependent kinase 22.7.11.220.450
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.449
4j95ACPFibroblast growth factor receptor 2/0.449
1dayGNPCasein kinase II subunit alpha2.7.11.10.448
3oroAGSSerine/threonine protein kinase/0.447
1dawANPCasein kinase II subunit alpha2.7.11.10.445
4ysjADPCalmodulin-like domain protein kinase/0.445
4zseANPEpidermal growth factor receptor2.7.10.10.445
1i44ACPInsulin receptor2.7.10.10.444
1ig1ANPDeath-associated protein kinase 12.7.11.10.444
3t8oATPRhodopsin kinase/0.444
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.443
2j0lANPFocal adhesion kinase 12.7.10.20.442
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.442
4c3pACPAurora kinase A2.7.11.10.442
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.441
1b39ATPCyclin-dependent kinase 22.7.11.220.441
1hckATPCyclin-dependent kinase 22.7.11.220.440
3c4wATPRhodopsin kinase/0.440