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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fkv61KCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fkv61KCyclin-dependent kinase 22.7.11.221.000
3lfnA27Cyclin-dependent kinase 22.7.11.220.614
3lfqA28Cyclin-dependent kinase 22.7.11.220.604
3s1h56ZCyclin-dependent kinase 22.7.11.220.600
3rmf20ZCyclin-dependent kinase 22.7.11.220.581
1y91CT9Cyclin-dependent kinase 22.7.11.220.579
2w17I19Cyclin-dependent kinase 22.7.11.220.574
4fkr45KCyclin-dependent kinase 22.7.11.220.573
3qtzX42Cyclin-dependent kinase 22.7.11.220.572
2vv9IM9Cyclin-dependent kinase 22.7.11.220.564
3rak03ZCyclin-dependent kinase 22.7.11.220.564
2r3lSCWCyclin-dependent kinase 22.7.11.220.560
2r3jSCJCyclin-dependent kinase 22.7.11.220.559
2b52D42Cyclin-dependent kinase 22.7.11.220.558
3rni21ZCyclin-dependent kinase 22.7.11.220.555
3s2pPMUCyclin-dependent kinase 22.7.11.220.555
3sw719KCyclin-dependent kinase 22.7.11.220.554
1oitHDTCyclin-dependent kinase 22.7.11.220.553
3sw418KCyclin-dependent kinase 22.7.11.220.553
4fkw62KCyclin-dependent kinase 22.7.11.220.553
1gih1PUCyclin-dependent kinase 22.7.11.220.552
4fko20KCyclin-dependent kinase 22.7.11.220.552
2w1hL0FCyclin-dependent kinase 22.7.11.220.551
4acm7YGCyclin-dependent kinase 22.7.11.220.550
2w05FRTCyclin-dependent kinase 22.7.11.220.549
3qtxX43Cyclin-dependent kinase 22.7.11.220.549
2w06FRVCyclin-dependent kinase 22.7.11.220.546
3ral04ZCyclin-dependent kinase 22.7.11.220.545
4ek816KCyclin-dependent kinase 22.7.11.220.545
3r9oZ71Cyclin-dependent kinase 22.7.11.220.544
1aq1STUCyclin-dependent kinase 22.7.11.220.543
2c6o4SPCyclin-dependent kinase 22.7.11.220.542
3ti1B49Cyclin-dependent kinase 22.7.11.220.542
4erwSTUCyclin-dependent kinase 22.7.11.220.542
2iw84SPCyclin-dependent kinase 22.7.11.220.540
3rpv26ZCyclin-dependent kinase 22.7.11.220.540
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.538
3r9dX6BCyclin-dependent kinase 22.7.11.220.538
1ke7LS3Cyclin-dependent kinase 22.7.11.220.537
2xmyCDKCyclin-dependent kinase 22.7.11.220.537
1pxmCK5Cyclin-dependent kinase 22.7.11.220.535
3r8lZ30Cyclin-dependent kinase 22.7.11.220.535
1h1s4SPCyclin-dependent kinase 22.7.11.220.534
1h1r6CPCyclin-dependent kinase 22.7.11.220.533
1gii1PUCyclin-dependent kinase 22.7.11.220.532
2r64740Cyclin-dependent kinase 22.7.11.220.530
1g5sI17Cyclin-dependent kinase 22.7.11.220.529
3rk708ZCyclin-dependent kinase 22.7.11.220.529
3r9hZ67Cyclin-dependent kinase 22.7.11.220.528
1ke6LS2Cyclin-dependent kinase 22.7.11.220.527
1p2a5BNCyclin-dependent kinase 22.7.11.220.525
1oguST8Cyclin-dependent kinase 22.7.11.220.523
2bhhRYUCyclin-dependent kinase 22.7.11.220.523
3r83Z14Cyclin-dependent kinase 22.7.11.220.523
1pxlCK4Cyclin-dependent kinase 22.7.11.220.522
3le62BZCyclin-dependent kinase 22.7.11.220.522
3rk507ZCyclin-dependent kinase 22.7.11.220.522
1oirHDYCyclin-dependent kinase 22.7.11.220.520
3rjc06ZCyclin-dependent kinase 22.7.11.220.518
1di8DTQCyclin-dependent kinase 22.7.11.220.517
2vttLZDCyclin-dependent kinase 22.7.11.220.516
4fkq42KCyclin-dependent kinase 22.7.11.220.516
3qtuX44Cyclin-dependent kinase 22.7.11.220.515
2vtsLZCCyclin-dependent kinase 22.7.11.220.514
1urwI1PCyclin-dependent kinase 22.7.11.220.513
3ezvEZVCyclin-dependent kinase 22.7.11.220.513
3qxpX64Cyclin-dependent kinase 22.7.11.220.513
1ykr628Cyclin-dependent kinase 22.7.11.220.512
2c5yMTWCyclin-dependent kinase 22.7.11.220.512
4fks46KCyclin-dependent kinase 22.7.11.220.512
2c6tDT5Cyclin-dependent kinase 22.7.11.220.511
2r3kSCQCyclin-dependent kinase 22.7.11.220.511
2iw94SPCyclin-dependent kinase 22.7.11.220.509
1v1k3FPCyclin-dependent kinase 22.7.11.220.508
3wblPDYCyclin-dependent kinase 22.7.11.220.508
4ez50RSCyclin-dependent kinase 62.7.11.220.508
2b55D31Cyclin-dependent kinase 22.7.11.220.507
2bheBRYCyclin-dependent kinase 22.7.11.220.506
3qu0X40Cyclin-dependent kinase 22.7.11.220.506
1pxpCK8Cyclin-dependent kinase 22.7.11.220.505
2b53D23Cyclin-dependent kinase 22.7.11.220.505
2vthLZ2Cyclin-dependent kinase 22.7.11.220.505
1fvv107Cyclin-dependent kinase 22.7.11.220.504
3unk0BYCyclin-dependent kinase 22.7.11.220.504
1oiuN76Cyclin-dependent kinase 22.7.11.220.503
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.503
3sqq99ZCyclin-dependent kinase 22.7.11.220.503
3qqkX02Cyclin-dependent kinase 22.7.11.220.502
2c6lDT4Cyclin-dependent kinase 22.7.11.220.501
2x1nX1NCyclin-dependent kinase 22.7.11.220.501
4eok4SPCyclin-dependent kinase 22.7.11.220.500
1oiyN41Cyclin-dependent kinase 22.7.11.220.499
1pkdUCNCyclin-dependent kinase 22.7.11.220.499
2uznC96Cyclin-dependent kinase 22.7.11.220.498
3qxoX65Cyclin-dependent kinase 22.7.11.220.498
1pyePM1Cyclin-dependent kinase 22.7.11.220.497
3ddqRRCCyclin-dependent kinase 22.7.11.220.497
3r7yZ04Cyclin-dependent kinase 22.7.11.220.497
2ds11CDCyclin-dependent kinase 22.7.11.220.496
2fvdLIACyclin-dependent kinase 22.7.11.220.496
3uli1N3Cyclin-dependent kinase 22.7.11.220.496
2a0cCK9Cyclin-dependent kinase 22.7.11.220.495
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.495
3py0SU9Cyclin-dependent kinase 22.7.11.220.495
3rkb12ZCyclin-dependent kinase 22.7.11.220.495
1oi9N20Cyclin-dependent kinase 22.7.11.220.494
2vu3LZECyclin-dependent kinase 22.7.11.220.494
1w8cN69Cyclin-dependent kinase 22.7.11.220.493
2pvnP63Casein kinase II subunit alpha2.7.11.10.493
4lyn1YGCyclin-dependent kinase 22.7.11.220.493
2uzoC62Cyclin-dependent kinase 22.7.11.220.492
3pj8404Cyclin-dependent kinase 22.7.11.220.492
1w0xOLOCyclin-dependent kinase 22.7.11.220.491
2eufLQQCyclin-dependent kinase 62.7.11.220.491
2a4lRRCCyclin-dependent kinase 22.7.11.220.490
3sheI85MAP kinase-activated protein kinase 32.7.11.10.490
3unj0BXCyclin-dependent kinase 22.7.11.220.490
2uzbC75Cyclin-dependent kinase 22.7.11.220.489
1pxoCK7Cyclin-dependent kinase 22.7.11.220.488
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.487
1ke5LS1Cyclin-dependent kinase 22.7.11.220.486
2c6iDT1Cyclin-dependent kinase 22.7.11.220.486
3qzhX69Cyclin-dependent kinase 22.7.11.220.486
3rk909ZCyclin-dependent kinase 22.7.11.220.486
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.485
3rm618ZCyclin-dependent kinase 22.7.11.220.485
4eor4SPCyclin-dependent kinase 22.7.11.220.485
4fx360KCyclin-dependent kinase 22.7.11.220.485
2c6kDT2Cyclin-dependent kinase 22.7.11.220.484
3ddpRC8Cyclin-dependent kinase 22.7.11.220.484
5cnoANPEpidermal growth factor receptor2.7.10.10.484
1ke9LS5Cyclin-dependent kinase 22.7.11.220.483
2wihP48Cyclin-dependent kinase 22.7.11.220.480
3rpo24ZCyclin-dependent kinase 22.7.11.220.480
1ckpPVBCyclin-dependent kinase 22.7.11.220.479
2duv371Cyclin-dependent kinase 22.7.11.220.479
3qqhX0ACyclin-dependent kinase 22.7.11.220.479
3rm719ZCyclin-dependent kinase 22.7.11.220.479
4bgh3I6Cyclin-dependent kinase 22.7.11.220.479
4fkt48KCyclin-dependent kinase 22.7.11.220.479
3r71X86Cyclin-dependent kinase 22.7.11.220.478
3dogNNNCyclin-dependent kinase 22.7.11.220.477
2uzdC85Cyclin-dependent kinase 22.7.11.220.476
3r1sX73Cyclin-dependent kinase 22.7.11.220.476
1dm2HMDCyclin-dependent kinase 22.7.11.220.475
2wxvWXVCyclin-dependent kinase 22.7.11.220.475
4bcpT3CCyclin-dependent kinase 22.7.11.220.475
4eon1ROCyclin-dependent kinase 22.7.11.220.475
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.475
1h0w207Cyclin-dependent kinase 22.7.11.220.474
3ezrEZRCyclin-dependent kinase 22.7.11.220.473
3r73X87Cyclin-dependent kinase 22.7.11.220.473
1gij2PUCyclin-dependent kinase 22.7.11.220.472
3qzgX67Cyclin-dependent kinase 22.7.11.220.472
3s0o50ZCyclin-dependent kinase 22.7.11.220.472
2r3iSCFCyclin-dependent kinase 22.7.11.220.471
3be9P04Casein kinase II subunit alpha2.7.11.10.471
3nieANPMitogen-activated protein kinase/0.471
3r1yX76Cyclin-dependent kinase 22.7.11.220.471
2wpa889Cyclin-dependent kinase 22.7.11.220.470
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.470
3r7vZ02Cyclin-dependent kinase 22.7.11.220.470
1ke8LS4Cyclin-dependent kinase 22.7.11.220.469
4aqc88ATyrosine-protein kinase JAK2/0.468
1e9hINRCyclin-dependent kinase 22.7.11.220.467
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.467
3lfsA07Cyclin-dependent kinase 22.7.11.220.467
3r6xX84Cyclin-dependent kinase 22.7.11.220.467
3roy22ZCyclin-dependent kinase 22.7.11.220.467
4bcnT9NCyclin-dependent kinase 22.7.11.220.467
1hckATPCyclin-dependent kinase 22.7.11.220.466
1v0oINRCell division control protein 2 homolog2.7.11.220.466
3qtrX36Cyclin-dependent kinase 22.7.11.220.466
1oiqHDUCyclin-dependent kinase 22.7.11.220.465
2btsU32Cyclin-dependent kinase 22.7.11.220.465
2cchATPCyclin-dependent kinase 22.7.11.220.465
2exmZIPCyclin-dependent kinase 22.7.11.220.465
3iggEFQCyclin-dependent kinase 22.7.11.220.465
3nux3NVCyclin-dependent kinase 62.7.11.220.465
3rahO1ZCyclin-dependent kinase 22.7.11.220.465
1eh4IC1Casein kinase I homolog 12.7.11.10.464
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.464
2xnbY8LCyclin-dependent kinase 22.7.11.220.464
4anmWULCasein kinase II subunit alpha2.7.11.10.464
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.464
4bcoT6QCyclin-dependent kinase 22.7.11.220.461
1b38ATPCyclin-dependent kinase 22.7.11.220.460
1xjdSTUProtein kinase C theta type2.7.11.130.460
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.460
3hmm855TGF-beta receptor type-12.7.11.300.460
1xddAAYIntegrin alpha-L/0.459
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.459
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.459
1dayGNPCasein kinase II subunit alpha2.7.11.10.458
2vtrLZBCyclin-dependent kinase 22.7.11.220.458
3r7iX9ICyclin-dependent kinase 22.7.11.220.458
3r7uX96Cyclin-dependent kinase 22.7.11.220.458
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.458
4qnyANPMitogen activated protein kinase, putative/0.458
2j9mPY8Cyclin-dependent kinase 22.7.11.220.457
2pvhP19Casein kinase II subunit alpha2.7.11.10.457
2r3r6SCCyclin-dependent kinase 22.7.11.220.457
3ig7EFPCyclin-dependent kinase 22.7.11.220.457
4j95ACPFibroblast growth factor receptor 2/0.457
2pvlP55Casein kinase II subunit alpha2.7.11.10.456
2r3p3SCCyclin-dependent kinase 22.7.11.220.456
3gubGUBDeath-associated protein kinase 12.7.11.10.456
4fkg4CKCyclin-dependent kinase 22.7.11.220.456
4fkpLS5Cyclin-dependent kinase 22.7.11.220.456
3gxlQIGTGF-beta receptor type-12.7.11.300.455
3r8vZ62Cyclin-dependent kinase 22.7.11.220.455
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.455
2c5nCK8Cyclin-dependent kinase 22.7.11.220.454
2uzeC95Cyclin-dependent kinase 22.7.11.220.454
3qtqX35Cyclin-dependent kinase 22.7.11.220.454
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.454
1r78FMDCyclin-dependent kinase 22.7.11.220.453
2vtqLZACyclin-dependent kinase 22.7.11.220.453
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.453
4bcmT7ZCyclin-dependent kinase 22.7.11.220.453
3qtwX3ACyclin-dependent kinase 22.7.11.220.452
3qwkX62Cyclin-dependent kinase 22.7.11.220.452
5cnnANPEpidermal growth factor receptor2.7.10.10.452
1vyw292Cyclin-dependent kinase 22.7.11.220.451
2uzlC94Cyclin-dependent kinase 22.7.11.220.451
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.451
1vyzN5BCyclin-dependent kinase 22.7.11.220.450
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.450
3nynSGVG protein-coupled receptor kinase 62.7.11.160.449
3qrtX14Cyclin-dependent kinase 22.7.11.220.449
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.449
4kd11QKCyclin-dependent kinase 22.7.11.220.449
4qmpDKISerine/threonine-protein kinase 242.7.11.10.449
1y8yCT7Cyclin-dependent kinase 22.7.11.220.448
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.448
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.448
3pe2E1BCasein kinase II subunit alpha2.7.11.10.448
4fklCK2Cyclin-dependent kinase 22.7.11.220.448
4hvi19STyrosine-protein kinase JAK32.7.10.20.448
1h1pCMGCyclin-dependent kinase 22.7.11.220.447
1h1q2A6Cyclin-dependent kinase 22.7.11.220.447
1pxkCK3Cyclin-dependent kinase 22.7.11.220.447
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.447
3my5RFZCyclin-dependent kinase 22.7.11.220.447
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.447
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.446
3qqgX06Cyclin-dependent kinase 22.7.11.220.446
4jia1K3Tyrosine-protein kinase JAK2/0.446
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.445
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.445
5dr6SKEAurora kinase A2.7.11.10.445
1fvt106Cyclin-dependent kinase 22.7.11.220.444
1m2pHNACasein kinase II subunit alpha2.7.11.10.444
2r3gSC9Cyclin-dependent kinase 22.7.11.220.444
2r3mSCXCyclin-dependent kinase 22.7.11.220.444
3ggfGVDSerine/threonine-protein kinase 26/0.444
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.444
2bkzSBCCyclin-dependent kinase 22.7.11.220.443
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.443
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.443
4i3zADPCyclin-dependent kinase 22.7.11.220.443
4zseANPEpidermal growth factor receptor2.7.10.10.443
1cc2FADCholesterol oxidase1.1.3.60.442
1unlRRCCyclin-dependent-like kinase 52.7.11.10.442
3qruX19Cyclin-dependent kinase 22.7.11.220.442
3r8pZ46Cyclin-dependent kinase 22.7.11.220.442
1pmn984Mitogen-activated protein kinase 102.7.11.240.441
2i40BLZCyclin-dependent kinase 22.7.11.220.441
4ii5ADPCyclin-dependent kinase 22.7.11.220.441
4lfiGNPCasein kinase II subunit alpha2.7.11.10.441
2f2cAP9Cyclin-dependent kinase 62.7.11.220.440
3qqlX03Cyclin-dependent kinase 22.7.11.220.440
4ek610KCyclin-dependent kinase 22.7.11.220.440
4jqeANPCasein kinase II subunit alpha2.7.11.10.440