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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fklCK2Cyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fklCK2Cyclin-dependent kinase 22.7.11.221.000
2a0cCK9Cyclin-dependent kinase 22.7.11.220.642
1w8cN69Cyclin-dependent kinase 22.7.11.220.623
2r3iSCFCyclin-dependent kinase 22.7.11.220.596
3r8vZ62Cyclin-dependent kinase 22.7.11.220.596
2ds11CDCyclin-dependent kinase 22.7.11.220.590
2c6kDT2Cyclin-dependent kinase 22.7.11.220.583
3lfqA28Cyclin-dependent kinase 22.7.11.220.570
1oitHDTCyclin-dependent kinase 22.7.11.220.565
2exmZIPCyclin-dependent kinase 22.7.11.220.563
1pxjCK2Cyclin-dependent kinase 22.7.11.220.561
3r83Z14Cyclin-dependent kinase 22.7.11.220.561
2vtsLZCCyclin-dependent kinase 22.7.11.220.560
3le62BZCyclin-dependent kinase 22.7.11.220.552
2r3jSCJCyclin-dependent kinase 22.7.11.220.550
2b55D31Cyclin-dependent kinase 22.7.11.220.543
3rahO1ZCyclin-dependent kinase 22.7.11.220.542
1h0w207Cyclin-dependent kinase 22.7.11.220.534
2c5yMTWCyclin-dependent kinase 22.7.11.220.534
1e1xNW1Cyclin-dependent kinase 22.7.11.220.533
2c6lDT4Cyclin-dependent kinase 22.7.11.220.533
2a4lRRCCyclin-dependent kinase 22.7.11.220.532
2r3gSC9Cyclin-dependent kinase 22.7.11.220.531
1aq1STUCyclin-dependent kinase 22.7.11.220.530
1b38ATPCyclin-dependent kinase 22.7.11.220.529
1g5sI17Cyclin-dependent kinase 22.7.11.220.529
1h0vUN4Cyclin-dependent kinase 22.7.11.220.529
2vtqLZACyclin-dependent kinase 22.7.11.220.526
4ek816KCyclin-dependent kinase 22.7.11.220.526
1oirHDYCyclin-dependent kinase 22.7.11.220.525
2r3fSC8Cyclin-dependent kinase 22.7.11.220.525
2c6iDT1Cyclin-dependent kinase 22.7.11.220.524
3rni21ZCyclin-dependent kinase 22.7.11.220.520
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.519
2r3lSCWCyclin-dependent kinase 22.7.11.220.517
2c68CT6Cyclin-dependent kinase 22.7.11.220.514
2c69CT8Cyclin-dependent kinase 22.7.11.220.513
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.513
3lfnA27Cyclin-dependent kinase 22.7.11.220.512
2r64740Cyclin-dependent kinase 22.7.11.220.510
3r7uX96Cyclin-dependent kinase 22.7.11.220.510
1ke6LS2Cyclin-dependent kinase 22.7.11.220.509
2b54D05Cyclin-dependent kinase 22.7.11.220.507
3s2pPMUCyclin-dependent kinase 22.7.11.220.507
3sheI85MAP kinase-activated protein kinase 32.7.11.10.507
2b53D23Cyclin-dependent kinase 22.7.11.220.505
3r7yZ04Cyclin-dependent kinase 22.7.11.220.505
2vthLZ2Cyclin-dependent kinase 22.7.11.220.503
1pxoCK7Cyclin-dependent kinase 22.7.11.220.502
4bcoT6QCyclin-dependent kinase 22.7.11.220.500
1y8yCT7Cyclin-dependent kinase 22.7.11.220.499
3rpo24ZCyclin-dependent kinase 22.7.11.220.498
2duv371Cyclin-dependent kinase 22.7.11.220.497
2uznC96Cyclin-dependent kinase 22.7.11.220.496
3qqlX03Cyclin-dependent kinase 22.7.11.220.496
1y91CT9Cyclin-dependent kinase 22.7.11.220.495
4acm7YGCyclin-dependent kinase 22.7.11.220.495
5cnoANPEpidermal growth factor receptor2.7.10.10.495
1ykr628Cyclin-dependent kinase 22.7.11.220.492
2c6o4SPCyclin-dependent kinase 22.7.11.220.492
3nynSGVG protein-coupled receptor kinase 62.7.11.160.492
4fkv61KCyclin-dependent kinase 22.7.11.220.492
3r7iX9ICyclin-dependent kinase 22.7.11.220.490
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.489
2w1hL0FCyclin-dependent kinase 22.7.11.220.489
3lfsA07Cyclin-dependent kinase 22.7.11.220.489
3nieANPMitogen-activated protein kinase/0.489
1gih1PUCyclin-dependent kinase 22.7.11.220.488
1w0xOLOCyclin-dependent kinase 22.7.11.220.488
4fkr45KCyclin-dependent kinase 22.7.11.220.488
1oiqHDUCyclin-dependent kinase 22.7.11.220.487
3r71X86Cyclin-dependent kinase 22.7.11.220.487
3r9nZ68Cyclin-dependent kinase 22.7.11.220.487
4fks46KCyclin-dependent kinase 22.7.11.220.486
3qqhX0ACyclin-dependent kinase 22.7.11.220.485
3r8lZ30Cyclin-dependent kinase 22.7.11.220.485
1ke7LS3Cyclin-dependent kinase 22.7.11.220.484
3qx2X63Cyclin-dependent kinase 22.7.11.220.484
4erwSTUCyclin-dependent kinase 22.7.11.220.484
1h1s4SPCyclin-dependent kinase 22.7.11.220.483
3sw418KCyclin-dependent kinase 22.7.11.220.483
2bhhRYUCyclin-dependent kinase 22.7.11.220.481
3fz1B98Cyclin-dependent kinase 22.7.11.220.481
4kd11QKCyclin-dependent kinase 22.7.11.220.481
1b39ATPCyclin-dependent kinase 22.7.11.220.480
1v1k3FPCyclin-dependent kinase 22.7.11.220.480
2r3p3SCCyclin-dependent kinase 22.7.11.220.479
2vv9IM9Cyclin-dependent kinase 22.7.11.220.479
1hckATPCyclin-dependent kinase 22.7.11.220.478
1pxlCK4Cyclin-dependent kinase 22.7.11.220.478
3r8uZ31Cyclin-dependent kinase 22.7.11.220.478
3qzhX69Cyclin-dependent kinase 22.7.11.220.477
3ezrEZRCyclin-dependent kinase 22.7.11.220.476
3r7vZ02Cyclin-dependent kinase 22.7.11.220.476
1urwI1PCyclin-dependent kinase 22.7.11.220.475
3sqq99ZCyclin-dependent kinase 22.7.11.220.475
2w17I19Cyclin-dependent kinase 22.7.11.220.474
3rmf20ZCyclin-dependent kinase 22.7.11.220.474
3s1h56ZCyclin-dependent kinase 22.7.11.220.473
3qx4X4BCyclin-dependent kinase 22.7.11.220.472
3rk708ZCyclin-dependent kinase 22.7.11.220.472
4nifANPMitogen-activated protein kinase 12.7.11.240.472
4eor4SPCyclin-dependent kinase 22.7.11.220.471
3ddpRC8Cyclin-dependent kinase 22.7.11.220.470
3eyhIZATyrosine-protein kinase JAK1/0.470
3r1yX76Cyclin-dependent kinase 22.7.11.220.470
3r73X87Cyclin-dependent kinase 22.7.11.220.470
3rk507ZCyclin-dependent kinase 22.7.11.220.470
2w05FRTCyclin-dependent kinase 22.7.11.220.469
3hmm855TGF-beta receptor type-12.7.11.300.469
3raiX85Cyclin-dependent kinase 22.7.11.220.469
5cnnANPEpidermal growth factor receptor2.7.10.10.469
1h1r6CPCyclin-dependent kinase 22.7.11.220.467
1gii1PUCyclin-dependent kinase 22.7.11.220.466
2w06FRVCyclin-dependent kinase 22.7.11.220.466
1di8DTQCyclin-dependent kinase 22.7.11.220.465
1pxmCK5Cyclin-dependent kinase 22.7.11.220.465
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
2r3kSCQCyclin-dependent kinase 22.7.11.220.464
2uzeC95Cyclin-dependent kinase 22.7.11.220.464
3sw719KCyclin-dependent kinase 22.7.11.220.464
4lyn1YGCyclin-dependent kinase 22.7.11.220.464
1pxpCK8Cyclin-dependent kinase 22.7.11.220.463
2b7aIZATyrosine-protein kinase JAK2/0.463
2iw94SPCyclin-dependent kinase 22.7.11.220.462
2x1nX1NCyclin-dependent kinase 22.7.11.220.462
3ddqRRCCyclin-dependent kinase 22.7.11.220.461
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.460
3rak03ZCyclin-dependent kinase 22.7.11.220.460
1h1q2A6Cyclin-dependent kinase 22.7.11.220.459
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
3rm618ZCyclin-dependent kinase 22.7.11.220.459
4fko20KCyclin-dependent kinase 22.7.11.220.459
1gz8MBPCyclin-dependent kinase 22.7.11.220.458
1pyePM1Cyclin-dependent kinase 22.7.11.220.458
2c6tDT5Cyclin-dependent kinase 22.7.11.220.458
1oguST8Cyclin-dependent kinase 22.7.11.220.457
2r3mSCXCyclin-dependent kinase 22.7.11.220.457
3iggEFQCyclin-dependent kinase 22.7.11.220.457
3qtzX42Cyclin-dependent kinase 22.7.11.220.457
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.457
1p2a5BNCyclin-dependent kinase 22.7.11.220.456
3qtxX43Cyclin-dependent kinase 22.7.11.220.456
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.456
3w551FMMitogen-activated protein kinase 12.7.11.240.456
3ggfGVDSerine/threonine-protein kinase 26/0.455
3ral04ZCyclin-dependent kinase 22.7.11.220.455
4bcpT3CCyclin-dependent kinase 22.7.11.220.455
1xjdSTUProtein kinase C theta type2.7.11.130.454
2uzbC75Cyclin-dependent kinase 22.7.11.220.454
2uzoC62Cyclin-dependent kinase 22.7.11.220.454
2xngA0HAurora kinase A2.7.11.10.454
4eok4SPCyclin-dependent kinase 22.7.11.220.454
5aniES4Cyclin-dependent kinase 22.7.11.220.454
1eh4IC1Casein kinase I homolog 12.7.11.10.453
2b52D42Cyclin-dependent kinase 22.7.11.220.453
2pvjP44Casein kinase II subunit alpha2.7.11.10.453
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.452
2i40BLZCyclin-dependent kinase 22.7.11.220.452
3r1qX75Cyclin-dependent kinase 22.7.11.220.452
3wblPDYCyclin-dependent kinase 22.7.11.220.452
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.452
2cchATPCyclin-dependent kinase 22.7.11.220.451
1oiuN76Cyclin-dependent kinase 22.7.11.220.450
4fv6E57Mitogen-activated protein kinase 12.7.11.240.450
2b9fADPMitogen-activated protein kinase FUS32.7.11.240.449
2c6mDT5Cyclin-dependent kinase 22.7.11.220.449
2iw84SPCyclin-dependent kinase 22.7.11.220.449
2y9qANPMitogen-activated protein kinase 12.7.11.240.449
4eon1ROCyclin-dependent kinase 22.7.11.220.448
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
3oroAGSSerine/threonine protein kinase/0.447
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3iok1P6Tyrosine-protein kinase JAK2/0.446
3rjc06ZCyclin-dependent kinase 22.7.11.220.446
4aqc88ATyrosine-protein kinase JAK2/0.446
3dogNNNCyclin-dependent kinase 22.7.11.220.445
3nux3NVCyclin-dependent kinase 62.7.11.220.445
3qyw6PBMitogen-activated protein kinase 12.7.11.240.445
3pxkPXKFocal adhesion kinase 12.7.10.20.444
3rkb12ZCyclin-dependent kinase 22.7.11.220.444
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
4fkw62KCyclin-dependent kinase 22.7.11.220.442
4nj32KDCyclin-dependent kinase 22.7.11.220.442
2xmyCDKCyclin-dependent kinase 22.7.11.220.441
3rk909ZCyclin-dependent kinase 22.7.11.220.441
4iva1J5Tyrosine-protein kinase JAK2/0.441
3ezvEZVCyclin-dependent kinase 22.7.11.220.440
3i60E86Mitogen-activated protein kinase 12.7.11.240.440
3my5RFZCyclin-dependent kinase 22.7.11.220.440
3qqgX06Cyclin-dependent kinase 22.7.11.220.440
3uli1N3Cyclin-dependent kinase 22.7.11.220.440