sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4fj1 | GEN | 17beta-hydroxysteroid dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4fj1 | GEN | 17beta-hydroxysteroid dehydrogenase | / | 1.000 | |
| 3qwi | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.664 | |
| 4fj0 | HHF | 17beta-hydroxysteroid dehydrogenase | / | 0.648 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.633 | |
| 4fj2 | QSO | 17beta-hydroxysteroid dehydrogenase | / | 0.625 | |
| 3qwh | KMP | 17beta-hydroxysteroid dehydrogenase | / | 0.607 | |
| 3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.509 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.509 | |
| 1syn | F89 | Thymidylate synthase | / | 0.506 | |
| 1zga | HMK | Isoflavone 4'-O-methyltransferase | / | 0.505 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.504 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.500 | |
| 4dyn | 0MR | Nucleoprotein | / | 0.500 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.497 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.496 | |
| 3sn7 | 540 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.495 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.494 | |
| 2lbd | REA | Retinoic acid receptor gamma | / | 0.493 | |
| 3pg3 | DG7 | Mitogen-activated protein kinase 14 | / | 0.492 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.492 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.491 | |
| 1siq | FAD | Glutaryl-CoA dehydrogenase, mitochondrial | 1.3.8.6 | 0.490 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.490 | |
| 3vg9 | ZMA | Adenosine receptor A2a | / | 0.490 | |
| 1c7o | PPG | Hemolysin | / | 0.489 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.489 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.489 | |
| 4ddl | 0JQ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.488 | |
| 3qak | UKA | Adenosine receptor A2a | / | 0.488 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.487 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.486 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.486 | |
| 4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.485 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.484 | |
| 4c3y | ANB | 3-ketosteroid dehydrogenase | / | 0.484 | |
| 4fev | PP1 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.484 | |
| 1g6o | ADP | Cag alpha | / | 0.482 | |
| 2ay9 | 5PV | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.482 | |
| 3v94 | WYQ | Phosphodiesterase | / | 0.482 | |
| 2b37 | 8PS | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.480 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.479 | |
| 2c9d | PHR | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.479 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.479 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.479 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.479 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.478 | |
| 2wey | EV1 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.478 | |
| 3nrr | D16 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.478 | |
| 4gkh | 0J9 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.478 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.477 | |
| 1p44 | GEQ | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.476 | |
| 1zg3 | 2HI | Isoflavone 4'-O-methyltransferase | / | 0.476 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.475 | |
| 1rpw | DID | HTH-type transcriptional regulator QacR | / | 0.475 | |
| 1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.475 | |
| 3q44 | D50 | M1 family aminopeptidase | 3.4.11 | 0.475 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.475 | |
| 1p33 | MTX | Pteridine reductase 1 | 1.5.1.33 | 0.474 | |
| 3c35 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.474 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 1qxl | FR8 | Adenosine deaminase | 3.5.4.4 | 0.473 | |
| 1sqv | UHD | Cytochrome b | / | 0.473 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.473 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.473 | |
| 3l05 | SN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.472 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.472 | |
| 4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.472 | |
| 4rh1 | 0TT | Spore photoproduct lyase | / | 0.472 | |
| 1r8q | AFB | Cytohesin-2 | / | 0.471 | |
| 1r8q | AFB | ADP-ribosylation factor 1 | / | 0.471 | |
| 2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.471 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.471 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.471 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.470 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.470 | |
| 4ap1 | NAP | Steroid monooxygenase | / | 0.470 | |
| 4ead | 0NP | Thymidine phosphorylase | 2.4.2.4 | 0.470 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.470 | |
| 4lb2 | DM5 | Serum albumin | / | 0.470 | |
| 1ej3 | CZH | Aequorin-2 | / | 0.469 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.469 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 4ej1 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1ohk | COP | Dihydrofolate reductase | 1.5.1.3 | 0.468 | |
| 1vrq | FON | Subunit alpha of sarocosine oxidase | / | 0.468 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 3ar4 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.468 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.468 | |
| 3rvi | RVI | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 4a2z | VIQ | Glycylpeptide N-tetradecanoyltransferase | / | 0.468 | |
| 4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.468 | |
| 4qtu | SAM | 18S rRNA (guanine(1575)-N(7))-methyltransferase | / | 0.468 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.467 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.467 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 3b3m | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.467 | |
| 4b14 | 4XB | Glycylpeptide N-tetradecanoyltransferase | / | 0.467 | |
| 1fvp | FMA | Non-fluorescent flavoprotein | / | 0.466 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 1u1d | 181 | Uridine phosphorylase | 2.4.2.3 | 0.466 | |
| 1u1f | 183 | Uridine phosphorylase | 2.4.2.3 | 0.466 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.466 | |
| 4a30 | QMI | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.466 | |
| 4l8u | 9AZ | Serum albumin | / | 0.466 | |
| 1hfp | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.465 | |
| 1kqu | BR4 | Phospholipase A2, membrane associated | / | 0.465 | |
| 1u1g | BBB | Uridine phosphorylase | 2.4.2.3 | 0.465 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.465 | |
| 2qd4 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.465 | |
| 2rds | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.465 | |
| 3c34 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.465 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.465 | |
| 4fhf | 0TT | Spore photoproduct lyase | / | 0.465 | |
| 4nu5 | NAD | Phosphonate dehydrogenase | 1.20.1.1 | 0.465 | |
| 5d1b | TSN | Histone deacetylase 8 | 3.5.1.98 | 0.465 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.464 | |
| 2fmn | 4HF | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.464 | |
| 3fnf | JPM | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 3h18 | PMS | Esterase/lipase | / | 0.464 | |
| 3vtc | TK3 | Vitamin D3 receptor | / | 0.464 | |
| 4eiy | ZMA | Adenosine receptor A2a | / | 0.464 | |
| 4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.464 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.464 | |
| 4lsl | 1YQ | Gag-Pol polyprotein | 2.7.7.49 | 0.464 | |
| 5hbs | RTL | Retinol-binding protein 1 | / | 0.464 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.463 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.463 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.463 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.463 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.463 | |
| 3kzo | AN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.463 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.463 | |
| 3sni | 546 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.463 | |
| 3wsb | RWZ | Farnesyltransferase, putative | / | 0.463 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.463 | |
| 4feu | 537 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.463 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.462 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.462 | |
| 3bxx | QUE | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.462 | |
| 3d2d | REN | Reticuline oxidase | 1.21.3.3 | 0.462 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.462 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.462 | |
| 3nxv | D2F | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 4dli | IRG | Mitogen-activated protein kinase 14 | / | 0.462 | |
| 4ea1 | 3RX | Dehydrosqualene synthase | / | 0.462 | |
| 4few | PP2 | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.462 | |
| 4ge7 | 0K5 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.462 | |
| 1hb1 | OCV | Isopenicillin N synthase | 1.21.3.1 | 0.461 | |
| 1ml6 | GBX | Glutathione S-transferase A2 | 2.5.1.18 | 0.461 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.461 | |
| 3k9u | ACO | Spermidine N(1)-acetyltransferase | / | 0.461 | |
| 3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.461 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.461 | |
| 4ea2 | RWZ | Dehydrosqualene synthase | / | 0.461 | |
| 5ab7 | MLC | Nonspecific lipid-transfer protein, putative | / | 0.461 | |
| 1i5a | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.460 | |
| 1jtq | LY3 | Thymidylate synthase | / | 0.460 | |
| 2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.460 | |
| 2ay3 | MPP | Aromatic-amino-acid aminotransferase | 2.6.1.57 | 0.460 | |
| 2z2w | 770 | Wee1-like protein kinase | 2.7.10.2 | 0.460 | |
| 3eku | CY9 | Actin-5C | / | 0.460 | |
| 3ha3 | SAH | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.460 | |
| 3njo | PYV | Abscisic acid receptor PYR1 | / | 0.460 | |
| 3nwl | NDP | Catalase | 1.11.1.6 | 0.460 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.460 | |
| 3up0 | D7S | aceDAF-12 | / | 0.460 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.460 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.460 | |
| 4bb6 | HD1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.460 | |
| 4dpd | DHF | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.460 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.460 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.459 | |
| 2jc6 | QPP | Calcium/calmodulin-dependent protein kinase type 1D | 2.7.11.17 | 0.459 | |
| 2pam | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.459 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.459 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.459 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.459 | |
| 3jzi | JZL | Biotin carboxylase | 6.3.4.14 | 0.459 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.459 | |
| 4dm6 | TTB | Retinoic acid receptor beta | / | 0.459 | |
| 4imu | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.459 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.459 | |
| 4kfj | 1R0 | Dihydrofolate reductase | 1.5.1.3 | 0.459 | |
| 1dis | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.458 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.458 | |
| 2pun | ACP | Methylthioribose kinase | 2.7.1.100 | 0.458 | |
| 2w6o | OA3 | Biotin carboxylase | 6.3.4.14 | 0.458 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.458 | |
| 3o73 | O73 | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.458 | |
| 4a6r | TA8 | Probable aminotransferase | / | 0.458 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.458 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 4gki | 0JN | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.458 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.458 | |
| 3rey | XAC | Adenosine receptor A2a | / | 0.458 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1c1c | 612 | Gag-Pol polyprotein | 2.7.7.49 | 0.457 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.457 | |
| 1yho | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2b36 | 5PP | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.457 | |
| 2fm0 | M98 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
| 2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 3ey4 | 352 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.457 | |
| 3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.457 | |
| 4bbx | LKF | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.457 | |
| 4keb | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 4l9k | EHF | Serum albumin | / | 0.457 | |
| 4yau | FAD | NADPH--cytochrome P450 reductase | / | 0.457 | |
| 7cat | NDP | Catalase | 1.11.1.6 | 0.457 | |
| 5iua | 6DX | Adenosine receptor A2a | / | 0.457 | |
| 3sn6 | P0G | Beta-2 adrenergic receptor | / | 0.457 | |
| 3rfm | CFF | Adenosine receptor A2a | / | 0.457 | |
| 1bzf | TMQ | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1so2 | 666 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.456 | |
| 2fk8 | SAM | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.456 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.456 | |
| 2rab | NAD | Glutathione amide reductase | / | 0.456 | |
| 3ntz | 3TZ | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3p9t | TCL | Repressor | / | 0.456 | |
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 0.456 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.456 | |
| 3vcy | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.456 | |
| 3w0y | DS4 | Vitamin D3 receptor | / | 0.456 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 4muw | 2F4 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.456 | |
| 5ej8 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.456 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.455 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.455 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.455 | |
| 1y6o | MJI | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.455 | |
| 2ham | C33 | Vitamin D3 receptor | / | 0.455 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2ovm | AS0 | Progesterone receptor | / | 0.455 | |
| 2rjp | 886 | A disintegrin and metalloproteinase with thrombospondin motifs 4 | 3.4.24.82 | 0.455 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.455 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 3b5i | SAH | Indole-3-acetate O-methyltransferase 1 | / | 0.455 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.455 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.455 | |
| 3k47 | D09 | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 3of1 | CMP | cAMP-dependent protein kinase regulatory subunit | / | 0.455 | |
| 3tfj | THG | Dimethylsulfonioproprionate demethylase DmdA | 2.1.1.269 | 0.455 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4geb | 0LD | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.455 | |
| 4kot | CE3 | Uncharacterized protein | / | 0.455 | |
| 4m6l | 21V | Dihydrofolate reductase | 1.5.1.3 | 0.455 | |
| 1db4 | 8IN | Phospholipase A2, membrane associated | / | 0.454 | |
| 1gnw | GTX | Glutathione S-transferase F2 | 2.5.1.18 | 0.454 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 1osv | CHC | Bile acid receptor | / | 0.454 | |
| 1xdk | REA | Retinoic acid receptor beta | / | 0.454 | |
| 1zdw | FLV | Prenyltransferase | / | 0.454 | |
| 2bak | AQZ | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 2jj2 | ANP | ATP synthase subunit beta, mitochondrial | 3.6.3.14 | 0.454 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.454 | |
| 2zl9 | VDA | Vitamin D3 receptor | / | 0.454 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.454 | |
| 3zhv | TDW | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.454 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4a9y | AQZ | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 4af7 | FAD | Ferredoxin--NADP reductase, leaf isozyme, chloroplastic | 1.18.1.2 | 0.454 | |
| 4n4v | 2GY | Tankyrase-1 | 2.4.2.30 | 0.454 | |
| 4tzt | 468 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.454 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.454 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.453 | |
| 1qkn | RAL | Estrogen receptor beta | / | 0.453 | |
| 1s36 | CEI | Obelin | / | 0.453 | |
| 1sej | F89 | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.453 | |
| 1xu7 | CPS | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.453 | |
| 3hl0 | NAD | Maleylacetate reductase | / | 0.453 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.453 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.453 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.452 | |
| 1fd0 | 254 | Retinoic acid receptor gamma | / | 0.452 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.452 | |
| 1opb | RET | Retinol-binding protein 2 | / | 0.452 | |
| 1re0 | AFB | ADP-ribosylation factor 1 | / | 0.452 | |
| 1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.452 | |
| 2fja | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.452 | |
| 2p1u | 4TN | Retinoic acid receptor RXR-alpha | / | 0.452 | |
| 2r8o | T5X | Transketolase 1 | / | 0.452 | |
| 3bqd | DAY | Glucocorticoid receptor | / | 0.452 | |
| 3iro | 2CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.452 | |
| 3ix4 | TX1 | Transcriptional activator protein LasR | / | 0.452 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.452 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.452 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.452 | |
| 5k2a | ZMA | Adenosine receptor A2a | / | 0.452 | |
| 1ezf | IN0 | Squalene synthase | 2.5.1.21 | 0.451 | |
| 1n71 | COA | Aac(6')-Ii protein | / | 0.451 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.451 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.451 | |
| 2h44 | 7CA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.451 | |
| 2w3a | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2w6p | OA4 | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.451 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.451 | |
| 3da2 | 4MD | Carbonic anhydrase 13 | 4.2.1.1 | 0.451 | |
| 3ogw | IMN | Lactoperoxidase | 1.11.1.7 | 0.451 | |
| 3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.451 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.451 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.451 | |
| 4ea0 | 651 | Dehydrosqualene synthase | / | 0.451 | |
| 4fcd | 0T6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 5d7q | 4I5 | NAD-dependent protein deacetylase sirtuin-2 | 3.5.1 | 0.451 | |
| 3uzc | T4E | Adenosine receptor A2a | / | 0.451 | |
| 1tsd | F89 | Thymidylate synthase | / | 0.450 | |
| 3clx | X22 | E3 ubiquitin-protein ligase XIAP | 6.3.2 | 0.450 | |
| 3jrx | S1A | Acetyl-CoA carboxylase 2 | / | 0.450 | |
| 3lan | KBT | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 3o56 | ZG1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.450 | |
| 3rin | I2O | Mitogen-activated protein kinase 14 | / | 0.450 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.450 | |
| 4c73 | TLH | 3-oxoacyl-ACP synthase | / | 0.450 | |
| 4ite | TEY | Vitamin D3 receptor | / | 0.450 | |
| 4kxj | P34 | Nucleoprotein | / | 0.450 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.450 | |
| 4m48 | 21B | Sodium-dependent dopamine transporter | / | 0.450 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.450 | |
| 3eml | ZMA | Adenosine receptor A2a | / | 0.450 | |
| 1db1 | VDX | Vitamin D3 receptor | / | 0.449 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.449 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.449 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.449 | |
| 1h36 | R88 | Squalene--hopene cyclase | 4.2.1.129 | 0.449 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.449 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.449 | |
| 2io6 | 330 | Wee1-like protein kinase | 2.7.10.2 | 0.449 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.449 | |
| 2pul | ACP | Methylthioribose kinase | 2.7.1.100 | 0.449 | |
| 3aba | FLI | Cytochrome P450 | / | 0.449 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3g4g | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.449 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.449 | |
| 3nxr | D2D | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 4azw | ATP | O-antigen chain terminator bifunctional methyltransferase/kinase WbdD | / | 0.449 | |
| 4cx5 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4fvx | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.449 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.449 | |
| 4rbs | 0RV | Metallo-beta-lactamase type 2 | / | 0.449 | |
| 4ryv | ZEA | Protein LlR18A | / | 0.449 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.449 | |
| 4y1b | NAP | AntE | / | 0.449 | |
| 4ztv | TA7 | Anthranilate phosphoribosyltransferase | / | 0.449 | |
| 5doz | NDP | JamJ | / | 0.449 | |
| 1tl3 | H20 | Gag-Pol polyprotein | 2.7.7.49 | 0.448 | |
| 1y2d | 4DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2fhk | MFN | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.448 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 2pak | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.448 | |
| 2xgs | 44P | Uncharacterized protein | / | 0.448 | |
| 2xvf | FAD | Putative flavin-containing monooxygenase | / | 0.448 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.448 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.448 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.448 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 3nhk | VAP | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.448 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.448 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.448 | |
| 3qls | 55V | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 3r6i | JMS | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.448 | |
| 4ock | ANP | N-acetylhexosamine 1-kinase | 2.7.1.162 | 0.448 | |
| 1fml | RTL | Retinol dehydratase | / | 0.447 | |
| 1mmv | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.447 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.447 | |
| 1ygj | RMC | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 1yhj | R6C | Pyridoxal kinase | 2.7.1.35 | 0.447 | |
| 2ejz | SAH | Diphthine synthase | / | 0.447 | |
| 2rdn | 1PL | 1-deoxypentalenic acid 11-beta-hydroxylase | 1.14.11.35 | 0.447 | |
| 2vq7 | FAD | Putative flavin-containing monooxygenase | / | 0.447 | |
| 3acy | 702 | Dehydrosqualene synthase | / | 0.447 | |
| 3c6t | M14 | Gag-Pol polyprotein | 2.7.7.49 | 0.447 | |
| 3lfe | Z84 | Mitogen-activated protein kinase 14 | / | 0.447 | |
| 3up3 | XCA | aceDAF-12 | / | 0.447 | |
| 3x0a | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.447 | |
| 4a6e | ASE | Acetylserotonin O-methyltransferase | 2.1.1.4 | 0.447 | |
| 4b4w | 9L9 | Bifunctional protein FolD | / | 0.447 | |
| 4qfx | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.447 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.447 | |
| 5iu4 | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 4uhr | NGI | Adenosine receptor A2a | / | 0.447 | |
| 1al8 | DHP | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.446 | |
| 1cf3 | FAD | Glucose oxidase | 1.1.3.4 | 0.446 | |
| 1db5 | 6IN | Phospholipase A2, membrane associated | / | 0.446 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.446 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.446 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.446 | |
| 2xtb | KRM | Adenosine kinase, putative | / | 0.446 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.446 | |
| 3qlz | QLZ | Uncharacterized protein | / | 0.446 | |
| 3sgy | 06W | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.446 | |
| 4eev | L1X | Hepatocyte growth factor receptor | 2.7.10.1 | 0.446 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.446 | |
| 4ixe | IXE | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.446 | |
| 4o1m | NAD | Enoyl-acyl carrier reductase | / | 0.446 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.446 | |
| 1dlr | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1exa | 394 | Retinoic acid receptor gamma | / | 0.445 | |
| 1icq | OPD | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.445 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.445 | |
| 2obx | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | 2.5.1.78 | 0.445 | |
| 2r8p | T6F | Transketolase 1 | / | 0.445 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.445 | |
| 2ydv | NEC | Adenosine receptor A2a | / | 0.445 | |
| 3dnt | ATP | Serine/threonine-protein kinase toxin HipA | / | 0.445 | |
| 3gc4 | AAQ | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.445 | |
| 3gcq | 1BU | Mitogen-activated protein kinase 14 | / | 0.445 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.445 | |
| 3pn1 | IVH | DNA ligase | / | 0.445 | |
| 3tfn | 2CJ | Dehydrosqualene synthase | / | 0.445 | |
| 3u8h | BHP | Phospholipase A2, membrane associated | / | 0.445 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.445 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.445 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.445 | |
| 4i6h | 1C8 | Serine/threonine-protein kinase PLK2 | 2.7.11.21 | 0.445 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.445 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.445 | |
| 1ao8 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1b2l | NDC | Alcohol dehydrogenase | 1.1.1.1 | 0.444 | |
| 1jnr | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.444 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.444 | |
| 1ra2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1rkh | VD2 | Vitamin D3 receptor | / | 0.444 | |
| 1s3w | TQT | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1uae | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.444 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 2f2s | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.444 | |
| 2fpc | SCG | Strictosidine synthase | 4.3.3.2 | 0.444 | |
| 2iej | S48 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 2ovv | PFH | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
| 2ow9 | SP6 | Collagenase 3 | 3.4.24 | 0.444 | |
| 3aos | JH2 | Hemolymph juvenile hormone binding protein | / | 0.444 | |
| 3i6r | J5Z | Dihydroorotate dehydrogenase (quinone), mitochondrial | 1.3.5.2 | 0.444 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 3oez | STI | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.444 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.444 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4bkj | STI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 0.444 | |
| 4eh8 | IRG | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 4fdn | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.444 | |
| 4g2i | 0VQ | Vitamin D3 receptor | / | 0.444 | |
| 4k88 | HFG | Bifunctional glutamate/proline--tRNA ligase | 6.1.1.15 | 0.444 | |
| 4nt3 | ZAW | Lactoperoxidase | 1.11.1.7 | 0.444 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.444 | |
| 5g53 | NEC | Adenosine receptor A2a | / | 0.444 | |
| 1bvr | THT | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.443 | |
| 1ejb | INJ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 1f12 | 3HC | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 1jom | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1o6r | R19 | Squalene--hopene cyclase | 4.2.1.129 | 0.443 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.443 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 1xng | DND | NH(3)-dependent NAD(+) synthetase | 6.3.1.5 | 0.443 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.443 | |
| 2wow | NDP | Trypanothione reductase | / | 0.443 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.443 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.443 | |
| 3blo | QEI | Queuine tRNA-ribosyltransferase | 2.4.2.29 | 0.443 | |
| 3c0g | 3AM | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.443 | |
| 3c1t | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.443 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.443 | |
| 3hll | I46 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3l06 | SN0 | N-acetylornithine carbamoyltransferase | 2.1.3.9 | 0.443 | |
| 3qe2 | FAD | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 3qfr | FAD | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
| 3sl6 | JN8 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 3uft | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 4c72 | TLG | 3-oxoacyl-ACP synthase | / | 0.443 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.443 | |
| 4ttj | FMC | Purine nucleoside phosphorylase DeoD-type | / | 0.443 | |
| 5bp9 | SAH | Putative methyltransferase protein | / | 0.443 | |
| 5h8t | RTL | Retinol-binding protein 1 | / | 0.443 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.442 | |
| 1i58 | ACP | Chemotaxis protein CheA | 2.7.13.3 | 0.442 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.442 | |
| 1s9d | AFB | Cytohesin-2 | / | 0.442 | |
| 1s9d | AFB | ADP-ribosylation factor 1 | / | 0.442 | |
| 1t13 | INI | 6,7-dimethyl-8-ribityllumazine synthase 2 | / | 0.442 | |
| 1tlc | F89 | Thymidylate synthase | / | 0.442 | |
| 1v7a | FRC | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.442 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.442 | |
| 2hb7 | O1C | Vitamin D3 receptor | / | 0.442 | |
| 2nn7 | M29 | Carbonic anhydrase 1 | 4.2.1.1 | 0.442 | |
| 2p1t | 3TN | Retinoic acid receptor RXR-alpha | / | 0.442 | |
| 2q7g | CCL | Pyrrolysine--tRNA ligase | / | 0.442 | |
| 3c1o | NAP | Eugenol synthase | / | 0.442 | |
| 3c3d | FO1 | 2-phospho-L-lactate transferase | / | 0.442 | |
| 3lth | UD1 | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.442 | |
| 3qfc | FAD | NADPH--cytochrome P450 reductase | / | 0.442 | |
| 4dlc | UMP | Deoxyuridine triphosphatase, putative | / | 0.442 | |
| 4fex | 0TO | Aminoglycoside 3'-phosphotransferase AphA1-IAB | / | 0.442 | |
| 4knz | CB3 | Thymidylate synthase | / | 0.442 | |
| 4xoq | F42 | Coenzyme F420:L-glutamate ligase | / | 0.442 | |
| 4xz3 | COA | Acyl-CoA synthetase (NDP forming) | / | 0.442 | |
| 1dib | L34 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.441 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 1nsg | RAD | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.441 | |
| 1nsg | RAD | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.441 | |
| 1s19 | MC9 | Vitamin D3 receptor | / | 0.441 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.441 | |
| 2a5k | AZP | Replicase polyprotein 1ab | 3.4.22 | 0.441 | |
| 2bbq | PFG | Thymidylate synthase | / | 0.441 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.441 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2q3e | UPG | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.441 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.441 | |
| 2x9g | LYA | Pteridine reductase | / | 0.441 | |
| 2y30 | SM8 | Putative repressor SimReg2 | / | 0.441 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3irm | 1CY | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3nr4 | PYV | Abscisic acid receptor PYL2 | / | 0.441 | |
| 3ufv | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.441 | |
| 3vt4 | 5YI | Vitamin D3 receptor | / | 0.441 | |
| 4a4l | 939 | Serine/threonine-protein kinase PLK1 | 2.7.11.21 | 0.441 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.441 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.441 | |
| 4jsh | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 4jvn | YUG | Estrogen sulfotransferase | 2.8.2.4 | 0.441 | |
| 4kf1 | HT5 | Aryldialkylphosphatase | 3.1.8.1 | 0.441 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.441 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.441 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.441 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.441 | |
| 1c1b | GCA | Gag-Pol polyprotein | 2.7.7.49 | 0.440 | |
| 1dna | CB3 | Thymidylate synthase | / | 0.440 | |
| 1krh | FAD | Benzoate 1,2-dioxygenase electron transfer component | 1.18.1.3 | 0.440 | |
| 1mcz | RMN | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 1nce | CB3 | Thymidylate synthase | / | 0.440 | |
| 1ohj | COP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.440 | |
| 1upw | 444 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.440 | |
| 1ybg | TAV | UDP-N-acetylglucosamine 1-carboxyvinyltransferase | / | 0.440 | |
| 1yin | CM3 | Estrogen receptor | / | 0.440 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.440 | |
| 2fxf | ACO | Diamine acetyltransferase 1 | / | 0.440 | |
| 2fzj | DH3 | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2hm9 | TRR | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 2oym | MNI | Endoglycoceramidase II | / | 0.440 | |
| 2zru | FMN | Isopentenyl-diphosphate delta-isomerase | / | 0.440 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.440 | |
| 3cxw | 7CP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.440 | |
| 3dge | ADP | Sensor histidine kinase | / | 0.440 | |
| 3eon | 341 | Glutaryl-CoA dehydrogenase | / | 0.440 | |
| 3go4 | SAH | Uncharacterized protein | / | 0.440 | |
| 3h6k | 33T | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3hv3 | R49 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 3sqw | ANP | ATP-dependent RNA helicase MSS116, mitochondrial | 3.6.4.13 | 0.440 | |
| 3w0g | W07 | Vitamin D3 receptor | / | 0.440 | |
| 3w6h | AZM | Carbonic anhydrase 1 | 4.2.1.1 | 0.440 | |
| 4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.440 | |
| 4bzb | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.440 | |
| 4gi2 | NAP | Crotonyl-CoA carboxylase/reductase | / | 0.440 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.440 | |
| 4ri1 | ACO | UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase | 2.3.1.202 | 0.440 | |
| 4tzk | 641 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4ybn | FAD | Flavin-nucleotide-binding protein | / | 0.440 | |
| 5agk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.440 | |
| 5ej7 | TD6 | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase | / | 0.440 | |
| 2ycz | I32 | Beta-1 adrenergic receptor | / | 0.440 | |
| 5k2c | ZMA | Adenosine receptor A2a | / | 0.440 |