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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fhy3ATTerminal uridylyltransferase cid1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4fhy3ATTerminal uridylyltransferase cid1/1.000
4fhpUTPTerminal uridylyltransferase cid1/0.601
4fh5UTPTerminal uridylyltransferase cid1/0.545
2q0cCTPPoly(A) polymerase, putative/0.544
2q0gUPUPoly(A) polymerase, putative/0.503
2ikfUTPPoly(A) polymerase, putative/0.501
2nomDUTPoly(A) polymerase, putative/0.498
3zu2NAIEnoyl-[acyl-carrier-protein] reductase [NADH]/0.496
2b51UTPRNA editing complex protein MP57/0.491
3ed1GA3Gibberellin receptor GID1/0.490
2q0dATPPoly(A) polymerase, putative/0.489
3adaNADSubunit alpha of sarocosine oxidase/0.485
2z4sADPChromosomal replication initiator protein DnaA/0.477
3a8wATPProtein kinase C iota type2.7.11.130.476
4ffrATPUncharacterized protein/0.475
3hk1B64Fatty acid-binding protein, adipocyte/0.473
3hu1AGSTransitional endoplasmic reticulum ATPase3.6.4.60.473
1olsTDP2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.471
2bxqIMNSerum albumin/0.470
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.470
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.470
4lgaA2OAbscisic acid receptor PYL2/0.470
4xvrGNPGTPase HRas/0.469
5a30AGSMitochondrial poly(A) polymerase/0.469
5k2dZMAAdenosine receptor A2a/0.469
2itqITQEpidermal growth factor receptor2.7.10.10.467
2yx6ADPUncharacterized protein/0.467
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.467
4ku2MYA3-oxoacyl-[ACP] synthase III/0.465
1e1qADPATP synthase subunit beta, mitochondrial3.6.3.140.464
1ykdCMPAdenylate cyclase/0.464
2b56UTPRNA editing complex protein MP57/0.464
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.464
4c36ZO9cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
4mv3ACPBiotin carboxylase6.3.4.140.464
4u0mGTPCyclic GMP-AMP synthase/0.464
1z5aADPType 2 DNA topoisomerase 6 subunit B/0.463
4kp71UQ1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic1.1.1.2670.463
4twnB96Ephrin type-A receptor 32.7.10.10.463
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
2bgjFADNADPH:ferredoxin reductase/0.462
2fpcSCGStrictosidine synthase4.3.3.20.462
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.462
2q0fUTPPoly(A) polymerase, putative/0.462
3evbSAHGenome polyprotein2.1.1.560.462
3hiyUTPUncharacterized protein/0.462
4u0sADPAdenosine monophosphate-protein transferase FICD2.7.7.n10.462
1i24UPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.461
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.461
1cs4FOKAdenylate cyclase type 2/0.460
1cs4FOKAdenylate cyclase type 5/0.460
2ipjFFAAldo-keto reductase family 1 member C2/0.460
3nmvPYVAbscisic acid receptor PYL2/0.460
4dxaGSPRas-related protein Rap-1b/0.460
3nf8CDQGag-Pol polyprotein/0.459
4iji99TGlutathione S-transferase-like protein YibF/0.459
1g2vTTPGlucose-1-phosphate thymidylyltransferase/0.458
1um0FMNChorismate synthase/0.458
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
2tohHBITyrosine 3-monooxygenase1.14.16.20.458
4bb3KKAIsopenicillin N synthase1.21.3.10.458
4cf7ADPAdenylate kinase/0.458
5hwrCOAHydroxymethylglutaryl-CoA synthase/0.458
2itpAEEEpidermal growth factor receptor2.7.10.10.457
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
3nmnPYVAbscisic acid receptor PYL1/0.457
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.457
4kxl6C62'-deoxynucleoside 5'-phosphate N-hydrolase 1/0.457
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.457
1f5fDHTSex hormone-binding globulin/0.456
1mrqSTRAldo-keto reductase family 1 member C1/0.456
1yrxFMNAppA protein/0.456
2zevIPEGeranylgeranyl pyrophosphate synthase/0.456
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.456
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.456
1tg2H2BPhenylalanine-4-hydroxylase1.14.16.10.455
1u71MXADihydrofolate reductase1.5.1.30.455
2w6zL21Biotin carboxylase6.3.4.140.455
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3nlwH4BNitric oxide synthase, brain1.14.13.390.455
4ajfF03cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
4ap1NAPSteroid monooxygenase/0.455
1h9zRWFSerum albumin/0.454
1hb1OCVIsopenicillin N synthase1.21.3.10.454
1hb3SCVIsopenicillin N synthase1.21.3.10.454
1meiMOAInosine-5'-monophosphate dehydrogenase/0.454
1oc1ASVIsopenicillin N synthase1.21.3.10.454
1tj0FADBifunctional protein PutA1.5.5.20.454
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2iviACWIsopenicillin N synthase1.21.3.10.454
2x0eTYDWsaF/0.454
2xvw9NRSerum albumin/0.454
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.454
3vt7VDXVitamin D3 receptor/0.454
4yusFMNFamily 3 adenylate cyclase/0.454
1e2jTHMThymidine kinase/0.453
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
1n3sGTPGTP cyclohydrolase 13.5.4.160.453
1nzfUPGDNA beta-glucosyltransferase/0.453
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2qa2FADPolyketide oxygenase CabE/0.453
2vcmM11Isopenicillin N synthase1.21.3.10.453
3ns2PYVAbscisic acid receptor PYL2/0.453
3sn7540cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
3zeiAWHO-acetylserine sulfhydrylase/0.453
4a99FADTetX family tetracycline inactivation enzyme/0.453
4ku5DCC3-oxoacyl-[ACP] synthase III/0.453
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
4ej4EJ4Delta-type opioid receptor/0.453
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2rgeGNPGTPase HRas/0.452
2v58LZJBiotin carboxylase6.3.4.140.452
3b1dPLSBetaC-S lyase/0.452
3d3p20AcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
3jpuTY4Transcriptional activator protein LasR/0.452
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.452
4ib3ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4m55NADUDP-glucuronic acid decarboxylase 14.1.1.350.452
1g6nCMPcAMP-activated global transcriptional regulator CRP/0.451
1n5qTNCActVA 6 protein/0.451
1upcTPPN(2)-(2-carboxyethyl)arginine synthase/0.451
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.451
2c3yHTLPyruvate synthase/0.451
2ddoATPPyridoxine/pyridoxal/pyridoxamine kinase/0.451
2rtoIMIStreptavidin/0.451
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.451
2xauADPPre-mRNA-splicing factor ATP-dependent RNA helicase PRP433.6.4.130.451
2zsiGA4Gibberellin receptor GID1A30.451
3oafOAGDihydrofolate reductase1.5.1.30.451
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.451
4jq3ZOMAldo-keto reductase family 1 member C2/0.451
4jxhHRCCytohesin-2/0.451
4kf1HT5Aryldialkylphosphatase3.1.8.10.451
4zwmPLPOrnithine aminotransferase, mitochondrial, putative/0.451
5iu4ZMAAdenosine receptor A2a/0.451
1z5cADPType 2 DNA topoisomerase 6 subunit B/0.450
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.450
2xvv9DNSerum albumin/0.450
3kdiA8SAbscisic acid receptor PYL2/0.450
4h5tADPHeat shock cognate 71 kDa protein/0.450
4h9753SDihydrofolate reductase1.5.1.30.450
4jzr4JREgl nine homolog 1/0.450
4l5b1UXDeoxycytidine kinase2.7.1.740.450
1hfqMOTDihydrofolate reductase1.5.1.30.449
1srfMTBStreptavidin/0.449
1xduSFGAclacinomycin 10-hydroxylase RdmB4.1.10.449
2fhnBNIAvidin-related protein 4/5/0.449
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.449
3dd125DGlycogen phosphorylase, liver form2.4.1.10.449
3eblGA4Gibberellin receptor GID1/0.449
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.449
4avlTMPPolymerase acidic protein/0.449
4hnc0UTMandelate racemase/0.449
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.449
4yaf2AMNADPH--cytochrome P450 reductase/0.449
5g53NECAdenosine receptor A2a/0.449
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.448
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.448
2w6oOA3Biotin carboxylase6.3.4.140.448
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3o57ZG2cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
4gllNADUDP-glucuronic acid decarboxylase 14.1.1.350.448
5a65TPPThiamine-triphosphatase3.6.1.280.448
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
1pg3PRXAcetyl-coenzyme A synthetase/0.447
1vcfFMNIsopentenyl-diphosphate delta-isomerase/0.447
2j0sANPEukaryotic initiation factor 4A-III3.6.4.130.447
3ad9NADSubunit alpha of sarocosine oxidase/0.447
3qizQI2Botulinum neurotoxin type A3.4.24.690.447
4dpuAGSMevalonate diphosphate decarboxylase/0.447
4dpy2P0Mevalonate diphosphate decarboxylase/0.447
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.447
4lsl1YQGag-Pol polyprotein2.7.7.490.447
4njoNADD-3-phosphoglycerate dehydrogenase, putative/0.447
4xqg1PSHomospermidine synthase2.5.1.440.447
1bk0ACVIsopenicillin N synthase1.21.3.10.446
1nzdUPGDNA beta-glucosyltransferase/0.446
1vyrFMNPentaerythritol tetranitrate reductase/0.446
1x7b041Estrogen receptor beta/0.446
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2erzHFScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.446
2qdsMCOMetallo-beta-lactamase type 2/0.446
2uzaHTLPyruvate synthase/0.446
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.446
3fzfATPHeat shock cognate 71 kDa protein/0.446
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
3wv9FEGHmd co-occurring protein HcgE/0.446
3zoiM2WIsopenicillin N synthase1.21.3.10.446
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4h2nFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.446
4jc51K5Stimulator of interferon genes protein/0.446
4jlj1NMDeoxycytidine kinase2.7.1.740.446
4m9aFDAAcyl-CoA dehydrogenase/0.446
4tx9AMZPhosphoribosyl isomerase A/0.446
4zlaBESCytosol aminopeptidase3.4.11.10.446
1a8rGTPGTP cyclohydrolase 13.5.4.160.445
1bcpATPPertussis toxin subunit 4/0.445
1bcpATPPertussis toxin subunit 5/0.445
1pq944BOxysterols receptor LXR-beta/0.445
1qiqACCIsopenicillin N synthase1.21.3.10.445
1ro98BRcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.445
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2dwpACP6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 32.7.1.1050.445
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.445
2zshGA3Gibberellin receptor GID1A30.445
3b2sB2STrichothecene 3-O-acetyltransferase/0.445
3c14FOKAdenylate cyclase type 2/0.445
3c14FOKAdenylate cyclase type 5/0.445
3ec7NADInositol 2-dehydrogenase/0.445
4iz02BIGenome polyprotein2.7.7.480.445
4jlm1NNDeoxycytidine kinase2.7.1.740.445
4mv4ACPBiotin carboxylase6.3.4.140.445
4zzjCNANAD-dependent protein deacetylase sirtuin-13.5.10.445
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
1lkeDOGBilin-binding protein/0.444
1x0pFADTll0078 protein/0.444
2oxtSAMGenome polyprotein/0.444
3wtiCT4Acetylcholine-binding protein/0.444
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.444
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.444
4ho8THMGlucose-1-phosphate thymidylyltransferase/0.444
4l0oPLPCystathionine gamma-synthase2.5.1.480.444
4qxaGTPRas-related protein Rab-9A/0.444
5uviZMAAdenosine receptor A2a/0.444
1nenDNTSuccinate dehydrogenase iron-sulfur subunit1.3.5.10.443
1nenDNTSuccinate dehydrogenase cytochrome b556 subunit/0.443
1r2jFADFkbI/0.443
1rszDIHPurine nucleoside phosphorylase2.4.2.10.443
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2acxANPG protein-coupled receptor kinase 62.7.11.160.443
2akyAP5Adenylate kinase/0.443
2eixFADNADH-cytochrome b5 reductase/0.443
3aw9NADNAD-dependent epimerase/dehydratase/0.443
3djfBC3Purine nucleoside phosphorylase/0.443
3dolGWIPol protein/0.443
3fowIMHPurine nucleoside phosphorylase/0.443
3fznD7KBenzoylformate decarboxylase4.1.1.70.443
3p2oNADBifunctional protein FolD/0.443
3thrC2FGlycine N-methyltransferase2.1.1.200.443
4g2fC07Ephrin type-A receptor 32.7.10.10.443
4i8vBHFCytochrome P450 1A11.14.14.10.443
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
1lwxAZDNucleoside diphosphate kinase, cytosolic2.7.4.60.442
1nd52BFProstatic acid phosphatase3.1.3.20.442
1uogP1CDeacetoxycephalosporin C synthase1.14.20.10.442
1yc2NADNAD-dependent protein deacylase 2/0.442
2g1m4HGEgl nine homolog 1/0.442
2r0pK2CPutative FAD-monooxygenase/0.442
2rhrEMOPutative ketoacyl reductase1.3.10.442
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3idbANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4ddrMMVDihydrofolate reductase1.5.1.30.442
4dk70KSOxysterols receptor LXR-beta/0.442
4ge1TSSBiogenic amine-binding protein/0.442
4jlk1NODeoxycytidine kinase2.7.1.740.442
4nhyPD2Prolyl 3-hydroxylase OGFOD11.14.110.442
4wa9AXITyrosine-protein kinase ABL12.7.10.20.442
5iubCLRAdenosine receptor A2a/0.442
7catNDPCatalase1.11.1.60.442
1bwkFMNNADPH dehydrogenase 11.6.99.10.441
1f9aATPNicotinamide-nucleotide adenylyltransferase/0.441
1g4tFTPThiamine-phosphate synthase/0.441
1mraAPGMandelate racemase/0.441
1v3sATPSignaling protein/0.441
2a9z26AAdenosine kinase2.7.1.200.441
2b8jADNClass B acid phosphatase3.1.3.20.441
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.441
2pdtFADVivid PAS protein VVD/0.441
2qo9ANPEphrin type-A receptor 32.7.10.10.441
2xf3J01Uncharacterized protein/0.441
3crzFADFerredoxin--NADP+ reductase/0.441
3ds6A17Mitogen-activated protein kinase 14/0.441
3e92G6AMitogen-activated protein kinase 14/0.441
3orfNADDihydropteridine reductase1.5.1.340.441
3pce3HPProtocatechuate 3,4-dioxygenase alpha chain1.13.11.30.441
3pce3HPProtocatechuate 3,4-dioxygenase beta chain1.13.11.30.441
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
3to3ATPPetrobactin biosynthesis protein AsbB/0.441
4eerFMNPhototropin-22.7.11.10.441
4jq7KJQEpidermal growth factor receptor2.7.10.10.441
1uyhPU0Heat shock protein HSP 90-alpha/0.440
2gfsPQBMitogen-activated protein kinase 14/0.440
2j3jHC4NADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.440
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2v5aLZLBiotin carboxylase6.3.4.140.440
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.440
2x7hPFNProstaglandin reductase 310.440
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
3fr5I4AFatty acid-binding protein, adipocyte/0.440
3itzP66Mitogen-activated protein kinase 14/0.440
3nloH4BNitric oxide synthase, brain1.14.13.390.440
3nmpPYVAbscisic acid receptor PYL2/0.440
3otwCOAPhosphopantetheine adenylyltransferase/0.440
3sl6JN8cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
3u2mFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.440
3wquATPCell division protein FtsA/0.440
3zhqTPPMultifunctional 2-oxoglutarate metabolism enzyme1.2.4.20.440
4bfwZVWPantothenate kinase2.7.1.330.440
4bfxZVXPantothenate kinase2.7.1.330.440
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.440
4oznATPAmmonium transporter/0.440
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
4ytnFD8Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial/0.440
4ytnFD8Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial/0.440
4ytnFD8Succinate dehydrogenase cytochrome b560/0.440
5a2yUTPMitochondrial poly(A) polymerase/0.440