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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.17

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.171.000
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.562
1jklANPDeath-associated protein kinase 12.7.11.10.521
3c4xATPRhodopsin kinase/0.520
3lltANPProtein serine/threonine kinase-1/0.517
5av2KMPDeath-associated protein kinase 12.7.11.10.517
2ijmADPFocal adhesion kinase 12.7.10.20.515
5dosATPAurora kinase A2.7.11.10.515
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.507
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.504
4j95ACPFibroblast growth factor receptor 2/0.504
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.503
3begANPSRSF protein kinase 12.7.11.10.502
2yaaATPDeath-associated protein kinase 2/0.501
5av3KMPDeath-associated protein kinase 12.7.11.10.500
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.499
5cvfATPCasein kinase II subunit alpha2.7.11.10.499
3dfcANPDeath-associated protein kinase 12.7.11.10.487
4ysjADPCalmodulin-like domain protein kinase/0.486
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.485
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.485
2j0lANPFocal adhesion kinase 12.7.10.20.484
3i60E86Mitogen-activated protein kinase 12.7.11.240.484
4l9i8PRRhodopsin kinase/0.484
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
3c4zADPRhodopsin kinase/0.482
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.481
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.480
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.479
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
4j99ACPFibroblast growth factor receptor 2/0.474
1m2pHNACasein kinase II subunit alpha2.7.11.10.473
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.473
4jboWPHAurora kinase A2.7.11.10.473
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.472
2j0m4STFocal adhesion kinase 12.7.10.20.471
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
3t8oATPRhodopsin kinase/0.471
2ojj82AMitogen-activated protein kinase 12.7.11.240.470
1ig1ANPDeath-associated protein kinase 12.7.11.10.469
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.468
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.466
3bu5ATPInsulin receptor2.7.10.10.464
3c4wATPRhodopsin kinase/0.464
3gu7ADPDeath-associated protein kinase 12.7.11.10.464
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.464
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.463
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3qc9ADPRhodopsin kinase/0.463
4qmlANPSerine/threonine-protein kinase 242.7.11.10.463
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.462
4aguD15Cyclin-dependent kinase-like 1/0.462
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.462
4jbpYPHAurora kinase A2.7.11.10.461
4ic7ANPMitogen-activated protein kinase 72.7.11.240.459
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
5dnrATPAurora kinase A2.7.11.10.459
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.458
2w4jADPDeath-associated protein kinase 12.7.11.10.457
4xlvACPInsulin receptor2.7.10.10.457
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.456
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.455
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
4eooATPCyclin-dependent kinase 22.7.11.220.455
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.455
2uzbC75Cyclin-dependent kinase 22.7.11.220.454
4btjADPTau-tubulin kinase 12.7.11.10.454
4qnyANPMitogen activated protein kinase, putative/0.454
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3juhANPCasein kinase II subunit alpha2.7.11.10.452
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.452
4y93746Tyrosine-protein kinase/0.452
1pjkANPCasein kinase II subunit alpha2.7.11.10.451
2ckeIQUDeath-associated protein kinase 2/0.451
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
3bqr4RBDeath-associated protein kinase 3/0.449
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.448
3gu6ADPDeath-associated protein kinase 12.7.11.10.448
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.448
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.447
2w05FRTCyclin-dependent kinase 22.7.11.220.447
1jkkANPDeath-associated protein kinase 12.7.11.10.446
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.446
4ez50RSCyclin-dependent kinase 62.7.11.220.446
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.446
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.445
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.445
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.445
4ii5ADPCyclin-dependent kinase 22.7.11.220.445
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.444
4deeADPAurora kinase A2.7.11.10.444
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.444
4o0wADNAurora kinase A2.7.11.10.444
2ijmATPFocal adhesion kinase 12.7.10.20.443
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.443
3zh8C58Protein kinase C iota type2.7.11.130.443
4fv6E57Mitogen-activated protein kinase 12.7.11.240.443
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.443
2zjwREFCasein kinase II subunit alpha2.7.11.10.442
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.441
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.441
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.441
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440