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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4feu537Aminoglycoside 3'-phosphotransferase AphA1-IAB/1.000
4fewPP2Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.566
4fevPP1Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.560
4fex0TOAminoglycoside 3'-phosphotransferase AphA1-IAB/0.545
4gkh0J9Aminoglycoside 3'-phosphotransferase AphA1-IAB/0.521
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.518
1synF89Thymidylate synthase/0.452
4mqt2CUMuscarinic acetylcholine receptor M2/0.445
1xddAAYIntegrin alpha-L/0.442
4mv1ADPBiotin carboxylase6.3.4.140.440