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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.34

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fc7NAPPeroxisomal 2,4-dienoyl-CoA reductase1.3.1.341.000
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.511
3p19NDPPutative blue fluorescent protein/0.503
1pr9NAPL-xylulose reductase1.1.1.100.488
2jahNDPClavaldehyde dehydrogenase/0.488
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.487
4bmvNAPShort-chain dehydrogenase/0.485
1ybmNAPUncharacterized protein At5g02240/0.484
4j7uNAPSepiapterin reductase1.1.1.1530.484
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.483
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.483
3toxNAPPutative oxidoreductase/0.481
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.481
3l77NJPShort-chain alcohol dehydrogenase/0.480
5dcyNAPIridoid synthase1.3.1.990.480
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.478
3qrwNDPPutative ketoacyl reductase1.3.10.478
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.476
4dc1NDPPutative ketoacyl reductase1.3.10.476
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.475
1ae1NAPTropinone reductase 1/0.474
1x7gNAPPutative ketoacyl reductase1.3.10.474
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.474
4hwkNAPSepiapterin reductase1.1.1.1530.474
1w4zNAPPutative ketoacyl reductase1.3.10.473
4j7xNAPSepiapterin reductase1.1.1.1530.473
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.471
1oaaNAPSepiapterin reductase1.1.1.1530.469
1snyNAPLD36273p/0.469
1xkqNDPUncharacterized protein/0.469
2bd0NAPSepiapterin reductase/0.469
5idwNAPShort-chain dehydrogenase/reductase SDR/0.469
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.468
1g6kNADGlucose 1-dehydrogenase1.1.1.470.466
1ipeNDPTropinone reductase 21.1.1.2360.466
2yutNAPPutative short-chain oxidoreductase/0.465
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.465
1n5dNDPCarbonyl reductase [NADPH] 1/0.463
3gy0NAPNAD(P)-dependent oxidoreductase/0.462
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.461
3sjuNDPKeto reductase/0.461
4qedNAPElxO/0.461
1x7hNDPPutative ketoacyl reductase1.3.10.460
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.460
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.459
3tn7NJPShort-chain alcohol dehydrogenase/0.459
3uceNDPDehydrogenase/0.458
1gcoNADGlucose 1-dehydrogenase1.1.1.470.457
4qecNAPElxO/0.457
1geeNADGlucose 1-dehydrogenase1.1.1.470.456
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.454
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.454
4impNDPPolyketide synthase extender modules 3-4/0.454
3u4cNDPNADPH-dependent reductase BacG/0.453
1xg5NAPDehydrogenase/reductase SDR family member 11/0.450
4gh5NADShort-chain dehydrogenase/reductase SDR/0.450
2dteNAIGlucose 1-dehydrogenase related protein/0.449
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.448
5dbgNADIridoid synthase1.3.1.990.448
3rj9NADAlcohol dehydrogenase1.1.1.10.446
5emhNAPIridoid synthase1.3.1.990.446
1rwbNADGlucose 1-dehydrogenase1.1.1.470.445
3wdsNADNADH-dependent quinuclidinone reductase/0.445
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.444
1nytNAPShikimate dehydrogenase (NADP(+))/0.444
1xq6NAPUncharacterized protein At5g02240/0.442
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.442
4esoNAPPutative oxidoreductase/0.441
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.440
2wdzNADGalactitol dehydrogenase/0.440
3slkNDPPolyketide synthase extender module 2/0.440