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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4f9wLM4Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4f9wLM4Mitogen-activated protein kinase 14/1.000
2ghmLICMitogen-activated protein kinase 14/0.575
4ewqMWLMitogen-activated protein kinase 14/0.530
1ywrLI9Mitogen-activated protein kinase 14/0.493
2ghlLIBMitogen-activated protein kinase 14/0.480
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.480
3w2sW2REpidermal growth factor receptor2.7.10.10.476
1pmn984Mitogen-activated protein kinase 102.7.11.240.475
3poz03PEpidermal growth factor receptor2.7.10.10.475
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.471
3cv9VDXVitamin D3 dihydroxylase/0.470
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.467
4hvb19PPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.465
1jioDEB6-deoxyerythronolide B hydroxylase/0.462
3w33W19Epidermal growth factor receptor2.7.10.10.462
3mpaSB2Mitogen-activated protein kinase 14/0.461
3zc3NAPFerredoxin--NADP reductase1.18.1.20.460
4kbk1QGCasein kinase I isoform delta2.7.11.10.460
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.459
1knuYPAPeroxisome proliferator-activated receptor gamma/0.458
3flsFLSMitogen-activated protein kinase 14/0.458
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.457
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.455
4bbe3O4Tyrosine-protein kinase JAK2/0.455
4jrnANPRhoptry kinase family protein/0.455
2hw2RFPRifampin ADP-ribosyl transferase/0.454
4gk2L66Ephrin type-A receptor 32.7.10.10.454
1bygSTUTyrosine-protein kinase CSK/0.452
1eupASD6-deoxyerythronolide B hydroxylase/0.452
2ewaSB2Mitogen-activated protein kinase 14/0.452
3igoANPCalmodulin-domain protein kinase 1, putative/0.452
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
4dlj6RGMitogen-activated protein kinase 14/0.451
3gc7B45Mitogen-activated protein kinase 14/0.449
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.448
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.448
3w32W32Epidermal growth factor receptor2.7.10.10.448
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.447
1jipKTN6-deoxyerythronolide B hydroxylase/0.446
1zyjBI5Mitogen-activated protein kinase 14/0.446
3et7349Protein-tyrosine kinase 2-beta2.7.10.20.446
3mvl38PMitogen-activated protein kinase 14/0.446
3vs3VSETyrosine-protein kinase HCK2.7.10.20.446
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.445
5aaaVGHALK tyrosine kinase receptor2.7.10.10.445
1k6tXN1Gag-Pol polyprotein3.4.23.160.444
1m13HYFNuclear receptor subfamily 1 group I member 2/0.444
3zokNAD3-dehydroquinate synthase, chloroplastic4.2.3.40.444
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.443
2vwu7X1Ephrin type-B receptor 42.7.10.10.443
3wecAUICytochrome P450/0.443
4nk92K5Fibroblast growth factor receptor 1/0.443
2ittAEEEpidermal growth factor receptor2.7.10.10.442
3nww3NWMitogen-activated protein kinase 14/0.442
5eypLOCTubulin beta chain/0.442
2pwlACPFibroblast growth factor receptor 2/0.441
2wleCOAPolysialic acid O-acetyltransferase/0.441
3uyt0CKCasein kinase I isoform delta2.7.11.10.441
4fob0USALK tyrosine kinase receptor2.7.10.10.441
4otiMI1Serine/threonine-protein kinase N1/0.441
5itzLOCTubulin beta-2B chain/0.441
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
3gubGUBDeath-associated protein kinase 12.7.11.10.440
3kf7L9GMitogen-activated protein kinase 14/0.440
3uvp048Mitogen-activated protein kinase 14/0.440
3uvqFS8Mitogen-activated protein kinase 14/0.440
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.440
4kb81QNCasein kinase I isoform delta2.7.11.10.440