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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4f7n0SVCyclin-dependent kinase 82.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4f7n0SVCyclin-dependent kinase 82.7.11.221.000
4f6s0SQCyclin-dependent kinase 82.7.11.220.591
4f7j0SUCyclin-dependent kinase 82.7.11.220.512
3npcB96Mitogen-activated protein kinase 92.7.11.240.507
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.507
3hv4L51Mitogen-activated protein kinase 14/0.466
3lfbZ87Mitogen-activated protein kinase 14/0.462
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
1kqoDNDNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.452
3fvlBHKCarboxypeptidase A13.4.17.10.452
1npxFADNADH peroxidase1.11.1.10.450
3i0pNADMalate dehydrogenase, putative/0.450
2jn3JN3Fatty acid-binding protein, liver/0.449
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.449
3fx6BPXCarboxypeptidase A13.4.17.10.449
3q43D66M1 family aminopeptidase3.4.110.449
1nhsFADNADH peroxidase1.11.1.10.446
3nnuEDBMitogen-activated protein kinase 14/0.445
4yduADPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
1wbsLI2Mitogen-activated protein kinase 14/0.442
2ok7FADFerredoxin--NADP reductase, apicoplast/0.442
1nhpFADNADH peroxidase1.11.1.10.441
2an9GDPGuanylate kinase2.7.4.80.441
5ap7SVEDual specificity protein kinase TTK2.7.12.10.440