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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4f6s0SQCyclin-dependent kinase 82.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4f6s0SQCyclin-dependent kinase 82.7.11.221.000
4f7n0SVCyclin-dependent kinase 82.7.11.220.572
2z3uCRRCytochrome P450/0.466
3a1l2CCCytochrome P450/0.465
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.461
3q43D66M1 family aminopeptidase3.4.110.460
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.457
3q44D50M1 family aminopeptidase3.4.110.457
1iepSTITyrosine-protein kinase ABL12.7.10.20.456
1jstATPCyclin-dependent kinase 22.7.11.220.456
5ap7SVEDual specificity protein kinase TTK2.7.12.10.454
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.452
2gesCOKPantothenate kinase2.7.1.330.451
3gqvNAPEnoyl reductase LovC10.451
1ig1ANPDeath-associated protein kinase 12.7.11.10.449
2bxoOPBSerum albumin/0.448
4xybNDPFormate dehydrogenase/0.447
2yimMC4Probable alpha-methylacyl-CoA racemase Mcr (2-methylacyl-CoA racemase) (2-arylpropionyl-CoA epimerase )/0.446
1pkfEPDEpothilone C/D epoxidase1.140.444
1qmzATPCyclin-dependent kinase 22.7.11.220.444
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.444
1zs6ADPNucleoside diphosphate kinase 32.7.4.60.443
2getCOKPantothenate kinase2.7.1.330.443
2wtkANPSTE20-related kinase adapter protein alpha/0.443
1mp0NADAlcohol dehydrogenase class-31.1.1.10.442
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2cjmATPCyclin-dependent kinase 22.7.11.220.442
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.442
3npcB96Mitogen-activated protein kinase 92.7.11.240.441
1mxtFAECholesterol oxidase1.1.3.60.440
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
4nxwADPMitochondrial dynamics protein MID51/0.440