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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ez50RSCyclin-dependent kinase 62.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ez50RSCyclin-dependent kinase 62.7.11.221.000
2w05FRTCyclin-dependent kinase 22.7.11.220.551
2vu3LZECyclin-dependent kinase 22.7.11.220.546
1gii1PUCyclin-dependent kinase 22.7.11.220.527
2w17I19Cyclin-dependent kinase 22.7.11.220.527
1gih1PUCyclin-dependent kinase 22.7.11.220.524
3nux3NVCyclin-dependent kinase 62.7.11.220.520
2vv9IM9Cyclin-dependent kinase 22.7.11.220.518
1pkdUCNCyclin-dependent kinase 22.7.11.220.515
3r9dX6BCyclin-dependent kinase 22.7.11.220.513
3zh8C58Protein kinase C iota type2.7.11.130.512
3at4CCKCasein kinase II subunit alpha2.7.11.10.511
4fkv61KCyclin-dependent kinase 22.7.11.220.507
3rak03ZCyclin-dependent kinase 22.7.11.220.505
3uli1N3Cyclin-dependent kinase 22.7.11.220.505
4hvi19STyrosine-protein kinase JAK32.7.10.20.505
2fvdLIACyclin-dependent kinase 22.7.11.220.502
4bcmT7ZCyclin-dependent kinase 22.7.11.220.502
4anmWULCasein kinase II subunit alpha2.7.11.10.500
1h1r6CPCyclin-dependent kinase 22.7.11.220.499
1v1k3FPCyclin-dependent kinase 22.7.11.220.497
3sqq99ZCyclin-dependent kinase 22.7.11.220.497
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.495
3lfnA27Cyclin-dependent kinase 22.7.11.220.492
4erwSTUCyclin-dependent kinase 22.7.11.220.492
1aq1STUCyclin-dependent kinase 22.7.11.220.491
2pvnP63Casein kinase II subunit alpha2.7.11.10.491
3lfqA28Cyclin-dependent kinase 22.7.11.220.489
3s1h56ZCyclin-dependent kinase 22.7.11.220.488
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.488
3qxpX64Cyclin-dependent kinase 22.7.11.220.487
1fvv107Cyclin-dependent kinase 22.7.11.220.486
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.485
3rmf20ZCyclin-dependent kinase 22.7.11.220.485
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.485
2uzbC75Cyclin-dependent kinase 22.7.11.220.484
2vtqLZACyclin-dependent kinase 22.7.11.220.484
4fkw62KCyclin-dependent kinase 22.7.11.220.484
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.484
5cvfATPCasein kinase II subunit alpha2.7.11.10.483
1yvj4STTyrosine-protein kinase JAK32.7.10.20.482
3ezvEZVCyclin-dependent kinase 22.7.11.220.482
3u4uLNHCasein kinase II subunit alpha2.7.11.10.482
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.482
1qmzATPCyclin-dependent kinase 22.7.11.220.480
3nup3NUCyclin-dependent kinase 62.7.11.220.480
1oiuN76Cyclin-dependent kinase 22.7.11.220.479
3lfsA07Cyclin-dependent kinase 22.7.11.220.479
4fx360KCyclin-dependent kinase 22.7.11.220.479
2iw94SPCyclin-dependent kinase 22.7.11.220.478
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.478
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.478
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.478
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.478
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.478
3qtuX44Cyclin-dependent kinase 22.7.11.220.477
4bcnT9NCyclin-dependent kinase 22.7.11.220.477
2b55D31Cyclin-dependent kinase 22.7.11.220.476
2uzdC85Cyclin-dependent kinase 22.7.11.220.476
2w06FRVCyclin-dependent kinase 22.7.11.220.476
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.476
1oguST8Cyclin-dependent kinase 22.7.11.220.475
3be9P04Casein kinase II subunit alpha2.7.11.10.475
4bcqTJFCyclin-dependent kinase 22.7.11.220.475
2c6o4SPCyclin-dependent kinase 22.7.11.220.474
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.474
4ix6ADPUncharacterized protein/0.474
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.473
2iw84SPCyclin-dependent kinase 22.7.11.220.473
1h1s4SPCyclin-dependent kinase 22.7.11.220.472
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.472
1y91CT9Cyclin-dependent kinase 22.7.11.220.472
2pvlP55Casein kinase II subunit alpha2.7.11.10.472
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.472
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.472
1ke6LS2Cyclin-dependent kinase 22.7.11.220.471
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.471
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.471
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.471
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.470
3q9xEMOCasein kinase II subunit alpha2.7.11.10.470
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.470
1oiyN41Cyclin-dependent kinase 22.7.11.220.469
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
5cu6ATPCasein kinase II subunit alpha2.7.11.10.469
1g5sI17Cyclin-dependent kinase 22.7.11.220.468
3zewSTUEphrin type-B receptor 42.7.10.10.468
1oi9N20Cyclin-dependent kinase 22.7.11.220.467
2pvhP19Casein kinase II subunit alpha2.7.11.10.467
2xmyCDKCyclin-dependent kinase 22.7.11.220.467
4ic7ANPMitogen-activated protein kinase 72.7.11.240.467
2ckeIQUDeath-associated protein kinase 2/0.466
2vttLZDCyclin-dependent kinase 22.7.11.220.466
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.466
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.465
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
3lltANPProtein serine/threonine kinase-1/0.465
4aguD15Cyclin-dependent kinase-like 1/0.465
1hckATPCyclin-dependent kinase 22.7.11.220.464
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.464
2h96893Mitogen-activated protein kinase 82.7.11.240.464
2zjwREFCasein kinase II subunit alpha2.7.11.10.464
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.464
4eooATPCyclin-dependent kinase 22.7.11.220.464
1oiqHDUCyclin-dependent kinase 22.7.11.220.463
1p2a5BNCyclin-dependent kinase 22.7.11.220.463
2j0m4STFocal adhesion kinase 12.7.10.20.463
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.463
3nga3NGCasein kinase II subunit alpha2.7.11.10.463
3tnwF18Cyclin-dependent kinase 22.7.11.220.463
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.463
1dawANPCasein kinase II subunit alpha2.7.11.10.462
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.462
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.462
3ezrEZRCyclin-dependent kinase 22.7.11.220.462
4btjATPTau-tubulin kinase 12.7.11.10.462
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.461
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.461
3rni21ZCyclin-dependent kinase 22.7.11.220.461
4hge15VTyrosine-protein kinase JAK2/0.461
4j95ACPFibroblast growth factor receptor 2/0.461
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.461
4wsqKSAAP2-associated protein kinase 12.7.11.10.461
2r3jSCJCyclin-dependent kinase 22.7.11.220.460
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.460
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.459
2w1hL0FCyclin-dependent kinase 22.7.11.220.459
3bqr4RBDeath-associated protein kinase 3/0.459
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.459
3qqkX02Cyclin-dependent kinase 22.7.11.220.459
3wowANPCasein kinase II subunit alpha2.7.11.10.459
1w8cN69Cyclin-dependent kinase 22.7.11.220.458
2eufLQQCyclin-dependent kinase 62.7.11.220.458
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.458
3i60E86Mitogen-activated protein kinase 12.7.11.240.458
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.458
3r9oZ71Cyclin-dependent kinase 22.7.11.220.458
3rpv26ZCyclin-dependent kinase 22.7.11.220.458
4aqc88ATyrosine-protein kinase JAK2/0.458
4ogrADNCyclin-dependent kinase 92.7.11.220.458
2b52D42Cyclin-dependent kinase 22.7.11.220.457
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.457
3qtrX36Cyclin-dependent kinase 22.7.11.220.457
3ral04ZCyclin-dependent kinase 22.7.11.220.457
4grb0XGCasein kinase II subunit alpha2.7.11.10.457
4ix5ANPUncharacterized protein/0.457
2cchATPCyclin-dependent kinase 22.7.11.220.456
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.456
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.456
3rkb12ZCyclin-dependent kinase 22.7.11.220.456
4bbe3O4Tyrosine-protein kinase JAK2/0.456
4qnyANPMitogen activated protein kinase, putative/0.456
3at3ATKCasein kinase II subunit alpha2.7.11.10.455
4ii5ADPCyclin-dependent kinase 22.7.11.220.455
1finATPCyclin-dependent kinase 22.7.11.220.454
1m2pHNACasein kinase II subunit alpha2.7.11.10.454
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
2vd5BI8Myotonin-protein kinase2.7.11.10.454
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.454
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.454
3r7yZ04Cyclin-dependent kinase 22.7.11.220.454
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.454
4hvh19RTyrosine-protein kinase JAK32.7.10.20.454
5av2KMPDeath-associated protein kinase 12.7.11.10.454
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.453
3eb0DRKUncharacterized protein/0.453
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.453
3rk708ZCyclin-dependent kinase 22.7.11.220.453
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.453
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.453
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.453
5eg3ACPFibroblast growth factor receptor 2/0.453
2bheBRYCyclin-dependent kinase 22.7.11.220.452
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3ddqRRCCyclin-dependent kinase 22.7.11.220.452
3gubGUBDeath-associated protein kinase 12.7.11.10.452
3kvxFMYMitogen-activated protein kinase 102.7.11.240.452
4bchT7ZCyclin-dependent kinase 92.7.11.220.452
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.452
4ji91M3Tyrosine-protein kinase JAK2/0.452
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.452
1pyePM1Cyclin-dependent kinase 22.7.11.220.451
2in6839Wee1-like protein kinase2.7.10.20.451
3qx2X63Cyclin-dependent kinase 22.7.11.220.451
4eor4SPCyclin-dependent kinase 22.7.11.220.451
4gmy0X5Tyrosine-protein kinase JAK2/0.451
4lyn1YGCyclin-dependent kinase 22.7.11.220.451
2i40BLZCyclin-dependent kinase 22.7.11.220.450
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.450
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.450
4eon1ROCyclin-dependent kinase 22.7.11.220.450
5cshATPCasein kinase II subunit alpha2.7.11.10.450
1jstATPCyclin-dependent kinase 22.7.11.220.449
2a0cCK9Cyclin-dependent kinase 22.7.11.220.449
2f2cAP9Cyclin-dependent kinase 62.7.11.220.449
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.449
3r71X86Cyclin-dependent kinase 22.7.11.220.449
2ds11CDCyclin-dependent kinase 22.7.11.220.448
3gu7ADPDeath-associated protein kinase 12.7.11.10.448
4bcoT6QCyclin-dependent kinase 22.7.11.220.448
4jr7GNPCasein kinase II subunit alpha2.7.11.10.448
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.448
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.448
2r3lSCWCyclin-dependent kinase 22.7.11.220.447
3my5RFZCyclin-dependent kinase 22.7.11.220.447
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3t14FADSulfide-quinone reductase/0.447
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.447
4fv9E71Mitogen-activated protein kinase 12.7.11.240.447
4oauADP2-5A-dependent ribonuclease3.1.260.447
1wvxBD4Death-associated protein kinase 12.7.11.10.446
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.446
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.446
3lpbNVBTyrosine-protein kinase JAK2/0.446
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.446
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.446
4btjADPTau-tubulin kinase 12.7.11.10.446
4dgnLU2Casein kinase II subunit alpha2.7.11.10.446
1gij2PUCyclin-dependent kinase 22.7.11.220.445
3pe2E1BCasein kinase II subunit alpha2.7.11.10.445
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3r1sX73Cyclin-dependent kinase 22.7.11.220.445
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.445
4jia1K3Tyrosine-protein kinase JAK2/0.445
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.445
1e9hINRCyclin-dependent kinase 22.7.11.220.444
1urwI1PCyclin-dependent kinase 22.7.11.220.444
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.444
2c6tDT5Cyclin-dependent kinase 22.7.11.220.444
3axwTIDCasein kinase II subunit alpha2.7.11.10.444
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.444
3lq5SLQCyclin-dependent kinase 92.7.11.220.444
3r9hZ67Cyclin-dependent kinase 22.7.11.220.444
3sw719KCyclin-dependent kinase 22.7.11.220.444
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.444
4eok4SPCyclin-dependent kinase 22.7.11.220.444
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.443
1pjkANPCasein kinase II subunit alpha2.7.11.10.443
1pxpCK8Cyclin-dependent kinase 22.7.11.220.443
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.443
3ddpRC8Cyclin-dependent kinase 22.7.11.220.443
3dogNNNCyclin-dependent kinase 22.7.11.220.443
3ormAGSSerine/threonine protein kinase/0.443
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.443
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.443
2cciATPCyclin-dependent kinase 22.7.11.220.442
2duv371Cyclin-dependent kinase 22.7.11.220.442
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.442
2ijmADPFocal adhesion kinase 12.7.10.20.442
1h0w207Cyclin-dependent kinase 22.7.11.220.441
1om1IQACasein kinase II subunit alpha2.7.11.10.441
1pxoCK7Cyclin-dependent kinase 22.7.11.220.441
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.441
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.441
2hog710Serine/threonine-protein kinase Chk12.7.11.10.441
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.441
3w2rW2REpidermal growth factor receptor2.7.10.10.441
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.441
4gt3ATPMitogen-activated protein kinase 12.7.11.240.441
4gub0Y4Casein kinase II subunit alpha2.7.11.10.441
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.441
4q5hANPProtein kinase OspG2.70.441
5auwQUEDeath-associated protein kinase 12.7.11.10.441
1h1q2A6Cyclin-dependent kinase 22.7.11.220.440
1ke7LS3Cyclin-dependent kinase 22.7.11.220.440
3l8p0CEAngiopoietin-1 receptor2.7.10.10.440
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.440
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.440
4acm7YGCyclin-dependent kinase 22.7.11.220.440
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.440
4b7sQLECytochrome P450 monooxygenase PikC/0.440
4dgo0JWCasein kinase II subunit alpha2.7.11.10.440
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.440
4hvg19QTyrosine-protein kinase JAK32.7.10.20.440
4k33ACPFibroblast growth factor receptor 32.7.10.10.440
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440