Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4eyjN61Mitogen-activated protein kinase 132.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4eyjN61Mitogen-activated protein kinase 132.7.11.241.000
3iw8HIZMitogen-activated protein kinase 14/0.526
4o2z046Mitogen-activated protein kinase/0.499
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.494
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.486
3hv5R24Mitogen-activated protein kinase 14/0.480
3ctj320Hepatocyte growth factor receptor2.7.10.10.478
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.471
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
3ce31FNHepatocyte growth factor receptor2.7.10.10.466
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.466
4eevL1XHepatocyte growth factor receptor2.7.10.10.465
3kq7KQ7Mitogen-activated protein kinase 14/0.463
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.459
3eta351Insulin receptor2.7.10.10.459
1iepSTITyrosine-protein kinase ABL12.7.10.20.457
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.452
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.450
3efl706Vascular endothelial growth factor receptor 22.7.10.10.449
4aa0AA0Mitogen-activated protein kinase 14/0.447
3lfbZ87Mitogen-activated protein kinase 14/0.445
3gcsBAXMitogen-activated protein kinase 14/0.444
4kaoKAOFocal adhesion kinase 12.7.10.20.444
3hng8STVascular endothelial growth factor receptor 12.7.10.10.443
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.441